Effect of premeal consumption of whey protein and its hydrolysate on food intake and postmeal glycemia and insulin responses in young adults

Abstract

WP consumed before a meal reduces food intake, postmeal blood glucose and insulin, and the ratio of cumulative blood glucose to insulin AUCs in a dose-dependent manner. Intact WP, but not WPH, contributes to blood glucose control by both insulin-dependent and insulin-independent mechanisms. This trial was registered at clinicaltrials.gov as NCT00988377 and NCT00988182.

Nonfat milk attenuates acute hyperglycemia in individuals with android obesity: A randomized control trial

“…We found no significant differences in glycemic responses between the trials involving nonfat milk and those with the control drink that included the same amount of protein. These results confirm previous findings that at least some of the beneficial effects of milk on glycemic responses can be attributed to its protein quantity (Akhavan et al., 2010, 2014; Ballard et al., 2013; Elwood et al., 2010; Fekete et al., 2016; Gannon et al., 1992; Jakubowicz et al., 2014; Manders et al., 2014). …”

“…Whey protein is more quickly digested and absorbed than casein protein causing it to appear in the bloodstream sooner. Whey protein ingestion reduces postprandial hyperglycemia without increases in C‐peptide release or insulin concentrations suggesting that whey may affect glucose clearance by stimulating insulin‐independent mechanisms (Akhavan et al., 2010, 2014). In spite of this, we observed improvements in the early phase of the OGTT in the highest tertile of android obesity.…”

“…Treatments were separated by a washout period of at least 1 week during which time subjects resumed normal dietary and physical activity patterns. Though initially designed to include a third arm (a carbohydrate control trial), it was deemed unnecessary in answering the present question as the comparison it would have allowed has already been well established (Akhavan et al., 2010; Petersen et al., 2009). …”

“…Recent research has demonstrated favorable effects in glycemic management when dairy products are combined with high‐carbohydrate meals (Fekete et al., 2016; Panahi, El Khoury, Luhovyy, Goff, & Anderson, 2013; Panahi et al., 2013). The majority of relevant findings in this area attribute attenuated hyperglycemia to the insulinotropic properties of dairy proteins (Akhavan, Luhovyy, Brown, Cho, & Anderson, 2010; Fekete et al., 2016; Floyd, Fajans, Conn, Knopf, & Rull, 1966; Jakubowicz et al., 2014; Manders et al., 2014; Schmid, Schusdziarra, Schulte‐Frohlinde, Maier, & Classen, 1989; Schmid et al., 1992). In fact, milk‐derived proteins elicit dose‐dependent decreases in postprandial hyperglycemia when consumed with a high‐carbohydrate meal (Akhavan et al., 2010).…”

“…The majority of relevant findings in this area attribute attenuated hyperglycemia to the insulinotropic properties of dairy proteins (Akhavan, Luhovyy, Brown, Cho, & Anderson, 2010; Fekete et al., 2016; Floyd, Fajans, Conn, Knopf, & Rull, 1966; Jakubowicz et al., 2014; Manders et al., 2014; Schmid, Schusdziarra, Schulte‐Frohlinde, Maier, & Classen, 1989; Schmid et al., 1992). In fact, milk‐derived proteins elicit dose‐dependent decreases in postprandial hyperglycemia when consumed with a high‐carbohydrate meal (Akhavan et al., 2010). However, no study has yet investigated whether milk can attenuate postprandial hyperglycemia independent of its protein quantity.…”