Effect of Premelting on Conductivity of DNA-Lipid Films

Kasumov, A.; Nakamae, Sawako; Cazayous, M.; Kawasaki, Takayoshi; Okahata, Yoshio

doi:10.1155/2009/540257

Cited by 2 publications

(3 citation statements)

References 23 publications

(36 reference statements)

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“…81 It is thought that earlier studies did not observe this phenomenon because of the addition of water to film samples and incomplete structural analysis, as the DNA was thought to have A, B, or C forms. 53,54,56,60,82 DNA in the honeycomb films has been reported to be double-stranded, presumably because of the high humidity required to maintain the structure. 62 However as a dry DNA-DDAB film is hydrated the reverse transitions of DNA and DDAB were observed simultaneously.…”

Section: Structural States and Transitions From The Dry To Wet Statementioning

confidence: 99%

“…The process is thought to occur cooperatively46 and is analogous to the chromatographic purification of nucleic acids by a hydrophobic column 81. It is thought that earlier studies did not observe this phenomenon because of the addition of water to film samples and incomplete structural analysis, as the DNA was thought to have A, B, or C forms 53,54,56,60,82. DNA in the honeycomb films has been reported to be double‐stranded, presumably because of the high humidity required to maintain the structure 62…”

Section: Initial Studies and Applications Of Solid‐state Na–lipid Materialsmentioning

confidence: 99%

“…Copyright 2005 Springer‐Verlag; Reprinted with permission from Ref 78. Copyright 2009 Hindawi Publishing Corporation; Reprinted with permission from Ref 82. Copyright 1998 American Chemical Society; Reprinted with permission from Ref 88.…”

Section: Initial Studies and Applications Of Solid‐state Na–lipid Materialsmentioning

confidence: 99%

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Self‐assembly and applications of nucleic acid solid‐state films

Gajria

Neumann

Tirrell

2011

WIREs Nanomed Nanobiotechnol

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While most nucleic acid (NA)-lipid or NA-polymer complexes are studied in solution, there is growing interest in understanding their properties as naturally derived, biodegradable, biocompatible, solid-state materials with tailorable properties influenced by environmental parameters. Therapeutic and cell programming applications comprise an important new research field, particularly in gene transfection and silencing using plasmid DNA and siRNA with targeted local delivery for use in cell culture. Dried solid films have lower nuclease degradation, fewer barriers to long term storage, and allow localized delivery by direct implantation in combination with controlled release and dosage adjustment. In contrast to particulate complexes or other methods of drug delivery which are prepared and must remain in solution, films can regain their biological activity once wetted. However our understanding of the types of cationic agents that predictably form self-standing films with NA is still limited. The self-assembly and structural, physical, and chemical properties of these materials are of key importance to maintaining their activity. We therefore discuss the material properties of NA-lipid and NA-polymer films as the focus of this article. Recent studies have indicated that there is also growing interest in NA films beyond bioengineering and medical applications in the fields of nano- and optoelectronics. We survey the self-assembly of solid-state materials composed of NA complexed with lipids, surfactants, or polymers, and summarize investigations of nanoscopic assembly, structure, optical, and macroscopic material properties. We further evaluate the current and future applications of NA-lipid and NA-polymer films and the benefits and drawbacks of each type.

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Section: Structural States and Transitions From The Dry To Wet Statementioning

confidence: 99%

Section: Initial Studies and Applications Of Solid‐state Na–lipid Materialsmentioning

confidence: 99%

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Self‐assembly and applications of nucleic acid solid‐state films

Gajria

Neumann

Tirrell

2011

WIREs Nanomed Nanobiotechnol

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Long range electronic transport in DNA molecules deposited across a disconnected array of metallic nanoparticles

Chepelianskii

Klinov

Kasumov

et al. 2012

Comptes Rendus. Physique

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We report in detail our experiments on the conduction of λ DNA molecules over a wide range of temperature deposited across slits in a few nanometers thick platinum film. These insulating slits were fabricated using focused ion beam etching and characterized extensively using near field and electron microscopy. This characterization revealed the presence of metallic Ga nanoparticles inside the slits, as a result of the ion etching. After deposition of λ DNA molecules, using a protocol that we describe in detail, some of the slits became conducting and exhibited superconducting fluctuations at low temperatures. We argue that the observed conduction was due to transport along DNA molecules, that interacted with the Ga nanoparticles present in the slit. At low temperatures when Ga becomes superconducting, induced superconductivity could therefore be observed. These results indicate that minute metallic particles can easily transfer charge carriers to attached DNA molecules and provide a possible reconciliation between apparently contradictory previous experimental results concerning the length over which DNA molecules can conduct electricity.

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Effect of Premelting on Conductivity of DNA-Lipid Films

Cited by 2 publications

References 23 publications

Self‐assembly and applications of nucleic acid solid‐state films

Self‐assembly and applications of nucleic acid solid‐state films

Long range electronic transport in DNA molecules deposited across a disconnected array of metallic nanoparticles

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