Effect of prenatal exposure to organophosphates and pyrethroid pesticides on neonatal anthropometric measures and gestational age

Gimenez-Asensio, María José; Hernandez, Antonio F.; Romero-Molina, Desire; Gonzalez-Alzaga, Beatriz; Luzardo, Octavio P.; Henríquez-Hernández, Luis Alberto; Boada, Luis D.; García-Cortés, Helena; Lopez-Flores, Inmaculada; Sanchez-Piedra, María Dolores; Aguilar-Garduño, Clemente; Lacasaña, Marina

doi:10.1016/j.envres.2023.116410

Cited by 14 publications

(4 citation statements)

References 38 publications

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“…Our study also found that the high-use area is over 4.0 times higher than the low-use area ( Table 1 ). This finding aligns with previous studies conducted in the same region, which estimated the pesticide use to be only 3.6 times higher [ 28 ]. This could be explained by the area with low pesticide use having a diverse range of woody crops, such as citrus, olive, almond, and fruit trees, and these crops require less pesticide application.…”

Section: Discussionsupporting

confidence: 92%

“…Almeria, a province of Andalusia, is known to have the largest concentration of greenhouses in the world, covering 32,827 ha [ 27 ]. This study divided the region into three areas—West Almeria, Central Almeria, and East Almeria—based on different pesticide use according to agronomic criteria provided by the Andalusian Council of Agriculture and coincident with the three health districts [ 28 , 29 , 30 ]. The West Almeria district has the highest use of pesticides, with a cultivated area of 22,189 ha (67.6% of the entire study area) and an annual consumption of approximately 6352.08 tons of pesticides.…”

Section: Methodsmentioning

confidence: 99%

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Environmental Exposure to Pesticides and the Risk of Child Neurodevelopmental Disorders

Parrón-Carrillo,

Nievas-Soriano,

Parrón-Carreño

et al. 2024

Medicina

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Background and Objectives: Neurodevelopment is a fragile brain process necessary for learning from the beginning of childhood to adulthood. During the procedure, several risks could affect it, including environmental factors such as neurotoxic chemicals or environmental pollutants and, within them, exposure to pesticides. Materials and Methods: This ecological descriptive study attempted to assess the association between environmental exposure to pesticides and neurodevelopmental disorders. This study was conducted on 4830 children diagnosed for 11 years in a total population of 119,897 children in three areas: high, medium, and low greenhouse concentrations. Results: Chromosomal abnormalities were the most common prenatal disorder (28.6%), while intrauterine physical factors were the least common (0.5%). Among perinatal diagnoses, gestational age less than 32 weeks was the most common (25%), while hyperbilirubinemia requiring exchange transfusion and birth complications was the least common (0.4%). Brain damage was the most common problem detected in postnatal diagnosis (36.7%), while unspecified postnatal abnormalities were the least common (3.1%). Conclusions: The areas with the highest greenhouse concentration had higher incidences of neurodevelopmental disorders, particularly in boys, and lower age of referral. Chromosomal abnormalities were prevalent for prenatal diagnoses, gestational age below thirty-two weeks for perinatal diagnoses, and brain damage for postnatal diagnoses. Future studies should analyze the connection between pesticide exposure and neurodevelopmental disorders using spatial point pattern analysis.

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Section: Discussionsupporting

confidence: 92%

Section: Methodsmentioning

confidence: 99%

Environmental Exposure to Pesticides and the Risk of Child Neurodevelopmental Disorders

Parrón-Carrillo,

Nievas-Soriano,

Parrón-Carreño

et al. 2024

Medicina

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“…Pesticides are known to be hazardous to the environment [ 90 ]. They are lethal to aquatic organisms [ 91 , 92 ] and potentially affect human development due to prenatal exposure [ 93 ] and hormone signaling dysfunction [ 94 ].…”

Section: Malaria Prevention Strategiesmentioning

confidence: 99%

Tiny Green Army: Fighting Malaria with Plants and Nanotechnology

Moraes-de-Souza,

de Moraes,

Silva

et al. 2024

Pharmaceutics

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Malaria poses a global threat to human health, with millions of cases and thousands of deaths each year, mainly affecting developing countries in tropical and subtropical regions. Malaria’s causative agent is Plasmodium species, generally transmitted in the hematophagous act of female Anopheles sp. mosquitoes. The main approaches to fighting malaria are eliminating the parasite through drug treatments and preventing transmission with vector control. However, vector and parasite resistance to current strategies set a challenge. In response to the loss of drug efficacy and the environmental impact of pesticides, the focus shifted to the search for biocompatible products that could be antimalarial. Plant derivatives have a millennial application in traditional medicine, including the treatment of malaria, and show toxic effects towards the parasite and the mosquito, aside from being accessible and affordable. Its disadvantage lies in the type of administration because green chemical compounds rapidly degrade. The nanoformulation of these compounds can improve bioavailability, solubility, and efficacy. Thus, the nanotechnology-based development of plant products represents a relevant tool in the fight against malaria. We aim to review the effects of nanoparticles synthesized with plant extracts on Anopheles and Plasmodium while outlining the nanotechnology green synthesis and current malaria prevention strategies.

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“…Neurotoxicity is considered a common feature of pyrethroid toxicity, and the potential effects have been extended to actions at the cerebellar level, linked to functional impairment of motor coordination [ 6 ]. Developmental neurotoxicity has received particular attention [ 7 ] and is supported by epidemiological studies associating pyrethroid exposure biomarkers with neonatal effects, such as prematurity and decreased gestational age [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Applicability of Food Monitoring Data for Assessing Relative Exposure Contributions of Pyrethroids in Retrospective Human Biomonitoring Risk Estimations

de Alba-Gonzalez,

González-Caballero,

Tarazona

2023

Toxics

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The use of pyrethroids is very broad and shows increasing trends. Human biomonitoring studies represent the best approach for realistic risk estimations, but their interpretation requires a tiered approach. A previous HBM4EU study indicated levels in European children groups just around the threshold for concern, requiring further refinement. The main difficulty is that several pyrethroids with different toxicity potencies generate the same urinary metabolites. As diet is the main pyrethroid source for the general population, EU food monitoring data reported by EFSA have been used to estimate the relative contribution of each pyrethroid. The main contributors were cypermethrin for DCCA and 3-PBA and lambda-cyhalothrin for CFMP. Urinary levels predicted from food concentration according to the EFSA diets were mostly within the range of measured levels, except 3-PBA and CFMP levels in children, both below measured levels. The predicted lower levels for 3-PBA can be explained by the very low Fue value, initially proposed as conservative, but that seems to be unrealistic. The discrepancies for CFMP are mostly for the highest percentiles and require further assessments. The refined assessments included the revision of the previously proposed human biomonitoring guidance values for the general population, HBM-GV Gen Pop, following recent toxicological reevaluations, and the estimation of hazard quotients (HQs) for each individual pyrethroid and for the combined exposure to all pyrethroids. All HQs were below 1, indicating no immediate concern, but attention is required, particularly for children, with HQs in the range of 0.2–0.3 for the highly exposed group. The application of probabilistic methods offers assessments at the population level, addressing the variability in exposure and risk and providing relevant information for Public Health impact assessments and risk management prioritization.

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Effect of prenatal exposure to organophosphates and pyrethroid pesticides on neonatal anthropometric measures and gestational age

Cited by 14 publications

References 38 publications

Environmental Exposure to Pesticides and the Risk of Child Neurodevelopmental Disorders

Environmental Exposure to Pesticides and the Risk of Child Neurodevelopmental Disorders

Tiny Green Army: Fighting Malaria with Plants and Nanotechnology

Applicability of Food Monitoring Data for Assessing Relative Exposure Contributions of Pyrethroids in Retrospective Human Biomonitoring Risk Estimations

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