Effect of prenatal levetiracetam exposure on motor and cognitive functions of rat offspring

In utero exposure to levetiracetam vs valproate

“…7 The current research is supported by many previous studies documenting the poor developmental outcome, including motor and language development, in children exposed in utero to VPA. 1,17,18 Research surrounding apoptosis in the rodent brain may go some way to explaining the developmental differences found between LEV-and VPA-exposed children.…”

“…4 Animal data report low malformation rates, 6 along with minimal impact on animal cognitive development following LEV exposure. 7 Unsurprisingly, then, the use of LEV in WWE has increased in recent years, while the use of VPA has declined. 8,9 Despite the increase in use of LEV, reliable information on the neurodevelopment and cognitive abilities of children exposed to LEV is limited.…”

Effects of Levetiracetam on neural tube development and closure of the chick embryos in ovo

“…Two years later, Manthey et al [26] investigated LEV and sulthiame on neurotoxic properties in developing rat brain and noted that LEV did not show any neurotoxic effect contrary to sulthiame.…”

Positive impact of levetiracetam on emotional learning and memory in naive mice

“…Physical, motor, cognitive and teratogenic effects of LEV exposure throughout pregnancy in rats have been established. It has been reported that LEV had only a transient impact on reflex maturation and no impact on physical and cognitive function in the offspring of rats exposed to the drug during pregnancy (Ozyurek et al, 2010).…”