Effect of prenatal waterpipe tobacco smoke on airway inflammation in murine model of asthma of adult offspring mice

Al‐Sawalha, Nour A.; Al-Bo'ul, Hanadi F; Alzoubi, Karem H.; Khabour, Omar F.; Thanawala, Vaidehi

doi:10.1080/08958378.2017.1385113

Cited by 18 publications

(18 citation statements)

References 50 publications

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“…In a rat exposure model, hookah smoke exposure was shown to be associated with low birth weight, increased neonatal death rate, and lower growth rate among offspring [125]. Additionally, prenatal exposure to hookah smoke in a murine model of asthma in adult mice offspring also induced airway inflammation and adversely affected lung function [126]. In utero exposure to hookah tobacco smoke in rats resulted in impaired memory and decreased brain-derived neurotrophic factor in hippocampus of adult male offspring rats [127].…”

Section: Hookah Health Hazardsmentioning

confidence: 99%

The effects of hookah/waterpipe smoking on general health and the cardiovascular system

Qasim

Alarabi

Alzoubi

et al. 2019

Environ Health Prev Med

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121

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Hookah or waterpipe smoking or use is an emerging trend in the US population, especially among the youth. The misperception of hookah being less harmful than cigarettes and the availability of different but “appealing” flavors are considered among the main reasons for this trend. Hookah users however are exposed to many of the same toxic compounds/by-products as cigarette users, but at dramatically higher levels, which might lead to more severe negative health effects. In fact, hookah users are at risks of infections, cancers, lung disease, and other medical conditions. Moreover, because of the overlapping toxicant/chemical profile to conventional cigarettes, hookah smoke effects on the cardiovascular system are thought to be comparable to those of conventional cigarettes. A major source of tobacco addiction is nicotine, whose levels in hookah are extremely variable as they depend on the type of tobacco used. Taken together, in this review of literature, we will provide insights on the negative health effects of hookah in general, with a focus on what is known regarding its impact on the cardiovascular system.

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Section: Hookah Health Hazardsmentioning

confidence: 99%

The effects of hookah/waterpipe smoking on general health and the cardiovascular system

Qasim

Alarabi

Alzoubi

et al. 2019

Environ Health Prev Med

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121

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“…Prenatal exposure to WTS reduced the activity of GPx while it increased the activity of catalase in testes of male offspring rats in the current study. We have shown previously that prenatal WTS exposure altered the oxidative stress balance in the brain (Al‐Sawalha et al, ) and lungs (Al‐Sawalha et al, ) of offspring animals. Ali and colleagues reported that active WTS exposure reduced the level of anti‐oxidant enzymes in mice testes compared with unexposed mice (Ali et al, ).…”

Section: Discussionmentioning

confidence: 87%

“…The testes were isolated and immersed in liquid nitrogen then stored at −80°C for further analysis. The tissues were homogenised in a lysis buffer with protease inhibitor cocktail (Sigma–Aldrich Corp.) utilising a homogeniser (Tissue Master‐125, Omni International) as described previously (Al‐Sawalha, Al‐Bo'ul, Alzoubi, Khabour, & Thanawala, ). The concentration of tissue protein in the homogenate was measured using a BioRAD kit.…”

Section: Methodsmentioning

confidence: 99%

Influence of prenatal waterpipe tobacco smoke exposure on reproductive hormones and oxidative stress of adult male offspring rats

et al. 2019

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Male infertility is adversely affected by tobacco cigarette smoking. Herein, the effects of prenatal waterpipe tobacco smoke (WTS) exposure on reproductive hormones and oxidative stress of adult offspring rats were evaluated. Pregnant rats received either fresh air or mainstream WTS (2 hr daily). Pregnancy outcomes, circulatory levels of follicle stimulating hormone (FSH), luteinizing hormone (LH) and prolactin, testicular levels of oestrogen, testosterone and oxidative stress biomarkers [catalase, superoxide dismutase (SOD), glutathione peroxidase (GPx) and thiobarbituric acid reactive substances (TBARS)] were assessed in their adult male offspring rats. Prenatal WTS exposure reduced the number of born offspring, female to pups ratio and birthweight (p < 0.05). Prenatal WTS exposure increased the circulatory levels of FSH and the testicular levels of oestrogen, testosterone and TBARS and catalase activity compared with control group (p < 0.05). However, GPx activity was reduced by WTS exposure (p < 0.05). There appeared to be a trend of increased LH and prolactin levels with prenatal WTS exposure; however, it was not statistically significant compared with control group (p > 0.05). The activity of SOD was not affected by prenatal WTS exposure (p > 0.05). In conclusion, prenatal WTS exposure altered reproductive hormones as well as oxidative stress biomarkers in adult male offspring rats.

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“…29 Cardiac tissues were surgically excised, placed on a filter paper, weighed, adequately washed in phosphate buffered saline and frozen at −80°C until time of tissue homogenization as described previously. 22,30 Homogenized tissues were centrifuged to remove insoluble materials at 15 000 × g for 15 minutes, at 4°C.…”

Section: Methodsmentioning

confidence: 99%

“…20 A human study revealed that prenatal WTS exposure reduced offspring birth weight and Apgar score as well as increased pulmonary complications at birth. 21 Furthermore, animal studies showed that prenatal exposure to WTS increased the susceptibility to develop airway inflammation in murine model of asthma 22 and memory impairment 23 in offspring animals. However, the effect of prenatal WTS on offspring's cardiac biomarkers is still unknown.…”

Section: Introductionmentioning

confidence: 99%

Effect of Prenatal Waterpipe Tobacco Smoke Exposure on Cardiac Biomarkers in Adult Offspring Rats

Al‐Sawalha

Al-Filali

Alzoubi

et al. 2019

J Cardiovasc Pharmacol Ther

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Introduction: The prevalence of waterpipe tobacco smoke (WTS) consumption is increased among pregnant woman. Prenatal cigarette smoke exposure increased the risk of developing cardiovascular diseases in offspring. The current study examined the effect of prenatal WTS exposure on inflammatory profile, oxidative stress, and cardiac biomarkers in adult offspring rats. Methods: Female rats received WTS (2 hours per day) or fresh air 1 day prior to mating and throughout the pregnancy period. The body and heart masses were measured in male offspring rats. The level of oxidative stress biomarkers, nitrate, inflammatory mediators (interleukin 6 [IL-6], tumor necrosis factor alpha [TNF-α]), and gene expression of protein kinase C epsilon, angiotensin 2 receptor one, and transforming growth factor beta1 were measured in cardiac tissue homogenates of 13-week-old male offspring rats. Results: Prenatal WTS exposure reduced body weight and increased heart to body weight ratio ( P < .05). Prenatal WTS exposure did not affect oxidative stress biomarkers (superoxide dismutase, glutathione peroxidase, and thiobarbituric acid reactive substances) but significantly increased catalase activity and nitrate level ( P < .05) in cardiac tissue of adult male offspring rats. In addition, prenatal exposure to WTS did not affect cardiac level of TNF-α and IL-6 as well as the gene expression of different cardiac modulators in adult male offspring rats ( P > .05). Conclusion: Prenatal WTS exposure has detrimental consequences on adult offspring rats by increasing the ratio of heart to body mass, increasing the catalase activity and nitrate level in cardiac tissue of adult male offspring rats.

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Effect of prenatal waterpipe tobacco smoke on airway inflammation in murine model of asthma of adult offspring mice

Cited by 18 publications

References 50 publications

The effects of hookah/waterpipe smoking on general health and the cardiovascular system

The effects of hookah/waterpipe smoking on general health and the cardiovascular system

Influence of prenatal waterpipe tobacco smoke exposure on reproductive hormones and oxidative stress of adult male offspring rats

Effect of Prenatal Waterpipe Tobacco Smoke Exposure on Cardiac Biomarkers in Adult Offspring Rats

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