Effect of preoperative biliary drainage in patients with moderately severe obstructive jaundice on the outcomes of pancreatoduodenectomy: A meta-analysis study

Wang, Xiaolei; Meng, Shanshan; Hu, Ying; Duan, Kehang; Feng, Weiwei

doi:10.21203/rs.2.18871/v1

Cited by 1 publication

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References 8 publications

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“…Elevated serum TBIL concentrations may indicate obstruction of the biliary tract. When bilirubin excretion is blocked, it may lead to liver insu ciency, nutrient metabolism disorders, an increase in bile duct pressure, and abnormal platelet production [29]. In addition, animal experiments have shown that biliary obstruction may also lead to increased levels of serum in ammatory cytokines and endotoxins, intestinal ora disorders, and intestinal mucosal barrier damage [30].…”

Section: Discussionmentioning

confidence: 99%

Total bilirubin level on postoperative day 3 in predicting clinically relevant pancreatic fistula after pancreaticoduodenectomy : a retrospective study

Wang,

Qin,

Zhang

et al. 2024

Preprint

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Background: The prevalence of clinically relevant postoperative pancreatic fistulas (CR-POPF) following pancreaticoduodenectomy (PD) is relatively high. Most studies on the prediction of CR-POPF are limited to pre-operation, while there are few indicators to predict CR-POPF in the early postoperative period. The purpose of this study was to investigate the value of total bilirubin (TBIL) level on postoperative day 3 in predicting CR-POPF after PD. Methods: The clinical data of 170 patients who underwent PD in our team from January 2015 to October 2022 was retrospectively analyzed into two groups: the CR-POPF group with a grade B or C pancreatic fistula (n = 37), the no CR-POPF group with a non-pancreatic fistula, and the biochemical fistula patients (n = 133). Univariate and multivariate analyses were used to screen the potential indicators for predicting CR-POPF. The predictive value of risk factors was assessed by area under the ROC curve. Results: Preoperative variables, including hemoglobin (Hb), C-reactive protein (CRP), TBIL, albumin (ALB), pancreatic texture, hemorrhage, duct diameter, and TBIL on postoperative day 3, were identified as predictors of clinically relevant postoperative pancreatic fistula (CR-POPF) after pancreaticoduodenectomy (PD) (p < 0.001). The multivariate logistic regression analysis revealed that pancreatic texture (p = 0.004), postoperative TBIL (p<0.001), and preoperative CRP (p = 0.048) were identified as independent risk variables. To predict CR-POPF, the area under the curve (AUC) of pancreatic texture, TBIL on the third day of surgery, and preoperative CRP were found to be 0.607, 0.824, and 0.726, respectively. Conclusion: The TBIL level on postoperative day 3 is a significant predictor of CR-POPF after PD which can accurately predict CR-POPF.

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Section: Discussionmentioning

confidence: 99%

Total bilirubin level on postoperative day 3 in predicting clinically relevant pancreatic fistula after pancreaticoduodenectomy : a retrospective study

Wang,

Qin,

Zhang

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

Effect of preoperative biliary drainage in patients with moderately severe obstructive jaundice on the outcomes of pancreatoduodenectomy: A meta-analysis study

Abstract: Background The purpose of this meta-analysis was to examine the impact of preoperative biliary

Cited by 1 publication

References 8 publications

Total bilirubin level on postoperative day 3 in predicting clinically relevant pancreatic fistula after pancreaticoduodenectomy : a retrospective study

Total bilirubin level on postoperative day 3 in predicting clinically relevant pancreatic fistula after pancreaticoduodenectomy : a retrospective study

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