Effect of Preoperative Creatinine Levels on Mortality after Coronary Artery Bypass Grafting Surgery: an Observational Study

Oliveira, Marcos Aurélio Barboza de; Santos, Carlos Alberto dos; Brandi, Antônio Carlos; Dotta, Ana Helena; Botelho, Paulo Henrique Husseini; Godoy, Moacir Fernandes de; Braile, Domingo Marcolino

doi:10.21470/1678-9741-2018-0261

Cited by 3 publications

(2 citation statements)

References 15 publications

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“…WBC play an essential role in cardiovascular disease, some studies have found elevated WBC was associated with cardiovascular complications and mortality in patients after CABG [ 29 , 32 ]. Creatinine increased during perioperative stage served as independent risk factor for mortality in patients after CABG, and some risk assessment models after cardiac surgery included creatinine [ 6 , 20 , 33 , 34 ]. SpO 2 as an earlier warning index of hypoxemia is very important prognostic factor for critically ill patients with cardiovascular disease [ 35 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

A novel nomogram for predicting 3-year mortality in critically ill patients after coronary artery bypass grafting

2021

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Background The long-term outcomes for patients after coronary artery bypass grafting (CABG) have been received more and more concern. The existing prediction models are mostly focused on in-hospital operative mortality after CABG, but there is still little research on long-term mortality prediction model for patients after CABG. Objective To develop and validate a novel nomogram for predicting 3-year mortality in critically ill patients after CABG. Methods Data for developing novel predictive model were extracted from Medical Information Mart for Intensive cart III (MIMIC-III), of which 2929 critically ill patients who underwent CABG at the first admission were enrolled. Results A novel prognostic nomogram for 3-year mortality was constructed with the seven independent prognostic factors, including age, congestive heart failure, white blood cell, creatinine, SpO2, anion gap, and continuous renal replacement treatment derived from the multivariable logistic regression. The nomogram indicated accurate discrimination in primary (AUC: 0.81) and validation cohort (AUC: 0.802), which were better than traditional severity scores. And good consistency between the predictive and observed outcome was showed by the calibration curve for 3-year mortality. The decision curve analysis also showed higher clinical net benefit than traditional severity scores. Conclusion The novel nomogram had well performance to predict 3-year mortality in critically ill patients after CABG. The prediction model provided valuable information for treatment strategy and postdischarge management, which may be helpful in improving the long-term prognosis in critically ill patients after CABG.

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Section: Discussionmentioning

confidence: 99%

A novel nomogram for predicting 3-year mortality in critically ill patients after coronary artery bypass grafting

2021

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“…A worse prognosis may result from the combination of some risk factors and higher admission creatinine values. Moreover, lower admission creatinine values have been linked with a protective impact, even among elderly patients and those with a high cardiopulmonary bypass time [29].…”

Section: Chronic Kidney Disease (Ckd)mentioning

confidence: 99%

Early and Late Survival and Associated Factors in Patients Undergoing Coronary Artery Bypass Grafting

Amouzeshi¹,

Amouzeshi²

2020

The Current Perspectives on Coronary Artery Bypass Grafting

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Several studies have aimed to compare the early and late survival rates and the related factors in patients who undergo coronary artery bypass grafting (CABG). Among such factors are age, gender, arrhythmia, stroke, serum procalcitonin level, number and type of grafts, diabetes mellitus, chronic kidney disease, chronic obstructive pulmonary disease (COPD), addiction, ejection fraction, transfusion of blood products, and the kind of technique (off-pump versus on-pump). Controversies surround early and late survival and some of the associated factors in patients undergoing CABG. Therefore, it appears vital to compare the early and late survival chances and the related factors after CABG.

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A study of clinical characteristics and risk factors of mortality associated with tigecycline (Preprint)

Wu¹,

Wu²,

Gao³

et al. 2022

Preprint

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BACKGROUND Tigecycline has a broad spectrum of antimicrobial activity and become more widely used. However, in 2010, the FDA warned that tigecycline was associated with an increased risk of death. The risk factors of tigecycline-associated mortality are still controversial. OBJECTIVE The objective of this study was to explore the related factors of mortality associated with tigecycline in a tertiary university hospital and to establish the risk assessment criteria for tigecycline associated mortality METHODS In a observational retrospective study, we enrolled 240 patients who had been treated for at least 3 days with tigecycline between January 2020 and December 2020. We compared the clinical characteristics of patients who died after tigecycline therapy (79 in the non-survivor group) with those who survived within 28 days after tigecycline therapy (161 in the survivor group) during the same hospitalization. We used a logistic regression model to find risk factors of tigecycline associated mortality. RESULTS In total, 240 patients were included in the analysis, 79 patients eventually died after tigecycline treatment. The ages of the non-survivor group and survivor group were 78.3±13.9 and 68.0±11.2 years old (p = 0.022), treatment duration were 11±8.5 and 7±6.6 day (p = 0.017), and the APACHE II score were 14.8±4.0 and 9.5±2.7 (p = 0.025). The serum creatinine (SCr) was significant difference before and after treated with tigecycline only in the non-survivor group and no significant difference in the survivor group. The proportion of the kidney failure events and change in creatinine value were greater in the non-survivor group after treated with tigecycline than in the survivor group (p < 0.001).. In the multivariate analysis, age(p=0.019), ΔCre(p＜0.001) , SCr(p=0.038), APACHE II score (p=0.031) were independently associated with mortality. An age of ≥79 years, ΔCre(μmol/L)≥36, SCr≥112 and APACHE II score≥12.7 were selected as the cutoff points for predicting tigecycline associated mortality. The distribution of non-survivors at different ranges of creatinine change showed higher percentages of mortality in patients with high ΔCre after tigecycline treatment. CONCLUSIONS This study identifies the risk factors for tigecycline associated mortality, and draws attention to the fact that there is an increased mortality risk in patients treated with tigecycline . The risk assessment criteria can be helpful to identify patients with high risk of tigecycline associated mortality. CLINICALTRIAL no trial

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Effect of Preoperative Creatinine Levels on Mortality after Coronary Artery Bypass Grafting Surgery: an Observational Study

Cited by 3 publications

References 15 publications

A novel nomogram for predicting 3-year mortality in critically ill patients after coronary artery bypass grafting

A novel nomogram for predicting 3-year mortality in critically ill patients after coronary artery bypass grafting

Early and Late Survival and Associated Factors in Patients Undergoing Coronary Artery Bypass Grafting

A study of clinical characteristics and risk factors of mortality associated with tigecycline (Preprint)

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