Effect of preoperative intravenous oxycodone administration on sufentanil consumption after retroperitoneal laparoscopic nephrectomy

Abstract

Background: The aim of this study was to evaluate the efficacy of preoperative intravenous oxycodone administration on postoperative sufentanil consumption in patients undergoing retroperitoneal laparoscopic nephrectomy. Methods: Fifty patients scheduled for retroperitoneal laparoscopic nephrectomy were enrolled and randomly assigned to two groups -patients in Group O (n = 25) received intravenously 0.1 mg kg -1 oxycodone; while the patients in Group C (n = 25) received 0.1 mL kg -1 normal saline for 2 min, 10 min before the operation. All of the participants received intravenous sufentanil patient-controlled analgesia (PCA) after extubation, using a PCA device. The sufentanil consumption, rescue analgesia, Ramsay sedation scale (RSS) and visual analogue scale (VAS) scores at rest and during cough, the overall satisfaction and undesired events were all assessed. Results: Cumulative sufentanil consumption delivered by PCA was significantly lower in Group O at all time points. VAS scores at rest and during coughing at 1, 2, 4, 8 and 12 hours after extubation of the patient were significantly lower in Group O than in Group C. There were no significant differences between the two groups according to the number of patients administered tramadol, RSS and the incidence of side effects. The degree of patients' satisfaction was higher in Group O. Conclusion: Preoperative intravenous oxycodone can reduce postoperative cumulative sufentanil consumption and postoperative pain intensity without an increase in side effects.

Effect of different doses of intravenous oxycodone and fentanyl on intubation-related hemodynamic responses

“…Oxycodone has been reported to be effective for controlling preoperative acute pain such as bone fracture, [18] and preoperative administration was associated with the beneficial effect of reducing postoperative opioid consumption without an increase in side effects. [19] Therefore, we assumed that intravenous oxycodone also could be used effectively to attenuate IRHRs, and we chose fentanyl 2 μg/kg and intravenous oxycodone for this study.…”

“…Oxycodone may affect intraoperative hemodynamics as well as the intraoperative and postoperative requirement for opioids, because the onset time of oxycodone and duration of action of intravenous oxycodone are about 3 minutes and 4 hours, respectively. [9,19,24] Therefore, further research is required to obtain the predictive ED 50 and ED 95 of oxycodone-based on age and sex, and to investigate the intraoperative and postoperative effects on hemodynamics and the analgesic requirements using these doses of oxycodone. In addition, further research is required to determine whether the recalculated oxycodone ED 95 (0.269 mg/kg) for preventing all IRHRs is also effective and has hemodynamic safety with larger sample size.…”

Comparison of oxycodone hydrochloride and sufentanil used in painless fiberbronchoscopy

“…But the oxycodone may also have a direct effect on the central and medulla cough antitussive effect and reduce the occurrence of bucking less inspection. 7 The number of patients included in our study was relative small. Further study with larger sample size is recommended to validate our data.…”

“…than group A; the blood flow mechanics changed, the change in heart rate was more stable and small during the procedure indicating the patients with a better analgesic effect in group B than group A. Oxycodone could be directly applied to μ and κ receptors in the bronchus that increases the tolerance of bronchoscopy patients and reduces the stress response during the operation. 7 These effects are conducive to the stability of circulatory system. It is interesting to note that the number of breaths, counted from the beginning of stage T2 until T5, in group A was significantly lower than in group B.…”

Wybór optymalnej metody znieczulenia podczas zabiegów przedniej resekcji odbytnicy — ocena

“…In the case of total intravenous anaesthesia (TIVA), intravenous agents are administered to cause loss of consciousness, ensure analgesia, loss of memory, sympathoadrenergic reflex control and skeletal muscle relaxation. The used opioids, which relax the muscles, are meant to stop the nociceptive impulses from the operative field, allow mechanic ventilation, and provide haemodynamic stabilisation for the patient [4]. General anaesthesia ought to foreseeably and within a limited scope of doses render the patient unconscious, allow fast adjustment of the depth of the anaesthesia to current needs, and not impair the functions of the circulatory system.…”