Effect of preoperative oral immune-enhancing nutritional supplement on patients at high risk of infection after cardiac surgery: a randomised placebo-controlled trial

Tepaske, Robert; Velthuis, Henk te; Straaten, Heleen M. Oudemans–van; Heisterkamp, S. H.; Deventer, S. J. H. Van; İnce, Can; Eysman, L.; Kesecioğlu, Jozef

doi:10.1016/s0140-6736(01)05836-6

Cited by 176 publications

(87 citation statements)

References 25 publications

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“…In a previous study conducted in Gondar [20], the arginine level in healthy individuals was 119 mM, which is similar to normal levels in Europeans [18]. A previous study has shown that arginine supplementation led to decreased morbidity from infectious diseases in high-risk patients undergoing surgery [21].…”

Section: Discussionsupporting

confidence: 66%

Arginine as an adjuvant to chemotherapy improves clinical outcome in active tuberculosis

Schӧn¹,

Eliáš²,

Moges³

et al. 2003

Eur Respir J

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Nitric oxide (NO) is involved in the host defence against tuberculosis (TB). Patients with TB exhibit increased catabolism and reduced energy intake. Thus the hypothesis for this study was that restoring a relative deficiency in the amino acid arginine, the substrate for mycobactericidal NO production, would improve the clinical outcome of TB by increasing NO production.In a randomised double-blind study, patients with smear-positive TB (n=120) were given arginine or placebo for 4 weeks in addition to conventional chemotherapy. Primary outcomes were sputum conversion, weight gain, and clinical symptoms after week 8. Secondary outcomes were sedimentation rate and levels of NO metabolites, arginine, citrulline, and tumour necrosis factor-a.Compared with the human immunodeficiency virus (HIV)-/TBz placebo group, the HIV-/TBz patients in the arginine group showed significant improvement, defined as increased weight gain, higher sputum conversion rate and faster reduction of symptoms, such as cough. The arginine level increased after week 2 in the HIV-/TBz arginine group (100.2 mM (range 90.5-109.9) versus 142.1 mM (range 114.1-170.1)) compared with the HIV-/TBz placebo group (105.5 mM (range 93.7-117.3) versus 95.7 mM (range 82.4-108.9)). HIV seroprevalence was 52.5%. No clinical improvement or increase in serum arginine was detected in arginine supplemented HIVz/TBz patients compared with placebo.Arginine is beneficial as an adjuvant treatment in human immunodeficiency virusnegative patients with active tuberculosis, most likely mediated by increased production of nitric oxide. Eur Respir J 2003; 21: 483-488.

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Section: Discussionsupporting

confidence: 66%

Arginine as an adjuvant to chemotherapy improves clinical outcome in active tuberculosis

Schӧn¹,

Eliáš²,

Moges³

et al. 2003

Eur Respir J

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“…Several studies have shown benefit from the use of supplementation with arginine, fatty acids and nucleotides in the reduction of infectious complications and the time of hospital stay in critical and surgical patients [11][12][13] . The process of liver regeneration after being triggered can be evaluated by several methods: liver weight, number of mitosis, components of deoxyribonucleic acid, synthesis rate of nuclear antigens, immunohistochemistry, gene expression, changes in serum protein levels, serological tests, enzymatic determination of proliferation markers and flow cytometry 14 .…”

Section: Discussion Discussion Discussion Discussionmentioning

confidence: 99%

Evaluation of liver regeneration diet supplemented with omega-3 fatty acids: experimental study in rats

Silva

Malafaia

Torres

et al. 2015

Rev. Col. Bras. Cir.

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Evaluation of liver regeneration diet supplemented with omega-3 fatty acids: experimental study in rats 393Rev. Col. Bras. Cir. 2015; 42(6): [393][394][395][396][397] Original Article Original Article Original Article Original Article Original Article DOI: 10.1590/0100-69912015006008 Evaluation of liver regeneration diet supplemented with omega-3 Evaluation of liver regeneration diet supplemented with omega-3 Evaluation of liver regeneration diet supplemented with omega-3 Evaluation of liver regeneration diet supplemented with omega-3 Evaluation of liver regeneration diet supplemented with omega-3 fatty acids: experimental study in rats fatty acids: experimental study in rats fatty acids: experimental study in rats fatty acids: experimental study in rats fatty acids: experimental study in rats Avaliação da regeneração hepática com dieta suplementada com ácidos graxos Avaliação da regeneração hepática com dieta suplementada com ácidos graxos Avaliação da regeneração hepática com dieta suplementada com ácidos graxos Avaliação da regeneração hepática com dieta suplementada com ácidos graxos Avaliação da regeneração hepática com dieta suplementada com ácidos graxos ômega-3: estudo experimental em ratos ômega-3: estudo experimental em ratos ômega-3: estudo experimental em ratos ômega-3: estudo experimental em ratos ômega-3: estudo experimental em ratos Objective Objective: to evaluate liver regeneration in rats after partial hepatectomy of 60% with and without action diet supplemented with fatty acids through the study of the regenerated liver weight, laboratory parameters of liver function and histological study. Methods Methods Methods Methods Methods: thirty-six Wistar rats, males, adults were used, weighing between 195 and 330 g assigned to control and groups. The supplementation group received the diet by gavage and were killed after 24h, 72h and seven days. Evaluation of regeneration occurred through analysis of weight gain liver, serum aspartate aminotransferase, alanine aminotransferase, gammaglutamyltranspeptidase, and mitosis of the liver stained with H&E. Results Results ResultsResults Results: the diet supplemented group showed no statistical difference (p>0.05) on the evolution of weights. Administration of fatty acids post-hepatectomy had significant reduction in gamma glutamyltransferase levels and may reflect liver regeneration. Referring to mitotic index, it did not differ between period of times among the groups. Conclusion Conclusion Conclusion Conclusion Conclusion: supplementation with fatty acids in rats undergoing 60% hepatic resection showed no significant interference related to liver regeneration.

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“…The group under treatment showed an increase in the host defences before surgery, through a significant increase in the expression of HLA-DR epitopes on monocytes. Moreover, IL-6 concentration showed a decrease, while delayed hypersensitivity response to antigens improved and persisted until discharge from hospital [19].…”

Section: The Role Of the Immune Systemmentioning

confidence: 94%

Immunonutrition in perioperative phase: An insight into the integrated treatment of cardiac surgery patients

L¹,

Maio²,

Cavone³

et al. 2015

J Integr Cardiol

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The clinical condition of a patient scheduled for surgery, in addition to being a crucial point for the positive result of the operation, is certainly able to affect also the post-surgery phase.For this reason, the patient needs to be evaluated globally and in an interdisciplinary way in order to limit eventual early or late complications after surgery as much as possible. In the last few years, the knowledge gained through the progress and developments of basic research aimed at assessing the effects of some principles having immunostimulant properties, has allowed a clearer understanding of the role of the gut and of the gut-associated lymphoid tissue (GALT) in the immunologic dynamics of protection of the body against extraneous pathogens and agents that regulate the tolerance to commensal bacteria and food antigens.

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Effect of preoperative oral immune-enhancing nutritional supplement on patients at high risk of infection after cardiac surgery: a randomised placebo-controlled trial

Cited by 176 publications

References 25 publications

Arginine as an adjuvant to chemotherapy improves clinical outcome in active tuberculosis

Arginine as an adjuvant to chemotherapy improves clinical outcome in active tuberculosis

Evaluation of liver regeneration diet supplemented with omega-3 fatty acids: experimental study in rats

Immunonutrition in perioperative phase: An insight into the integrated treatment of cardiac surgery patients

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