In order to realize the resource utilization of coal gasification slag (CGS) and to effectively control the emission of nitrogen oxides (NO x ) in coke oven gas, the effect of the reaction conditions and vanadium loading over the CGS catalysts was carried out for the selective catalytic reduction (SCR) of NO by NH 3 . The various vanadium loaded CGS catalysts were prepared using impregnation methods. The addition of 1% vanadium to the CGS catalyst (V1/CGS) significantly enhanced the NO conversion at a wide temperature range of 180-290 • C. The catalysts were characterized by N 2 adsorption/desorption, X-ray photoelectron spectroscopy, H 2 -temperature programmed reduction, NH 3 -temperature programmed desorption, Inductively coupled plasma optical emission spectrometer (ICP-OES), thermo gravimetric analyses (TGA), Fourier Transform infrared spectroscopy (FTIR), Scanning electron microscope-Energy dispersive spectrometer (SEM-EDS), and X-ray powder diffraction (XRD). The experimental results show the following: That (1) the NO removal efficiency of the sample CGS 3 was the best, and it could be up to 100% under the experimental conditions;(2) The NO removal efficiency of the catalysts was higher in the atmosphere with SO 2 than that without SO 2 ; (3) The XRD results indicated the active component of vanadium was homogeneously dispersed over CGS and the active component of catalyst was V 2 O 5 according to the XPS results. In particular, the NH 3 -TPD spectra of the vanadium loaded CGS catalyst showed that vanadium produced more acid sites, and the Lewis acid sites on the vanadium species were the active sites for the catalytic reduction of NO at 240-290 • C.