Effect of prepubertal consumption of zearalenone on puberty and subsequent reproduction of gilts.

Abstract

Forty-eight prepubertal gilts (178.7 +/- 4.1 d; 94.2 +/- 4.1 kg), 16 in each of three trials, were assigned randomly to receive 0 (C) or 10 ppm zearalenone (Z) daily in 2.5 kg of a 14% protein finishing ration for 2 wk. Blood samples were collected at 20-min intervals for 4 h 1 wk after the start of the experiment and 1 wk after Z was withdrawn. Two weeks after Z was withdrawn, gilts were exposed to mature boars 15 min per day for 3 wk. Gilts in estrus were mated to two different boars 12 h apart. Twice each week, blood was sampled and analyzed for progesterone to establish age of puberty. Age at puberty differed (P = .008) among replicates but was similar (P = .13) between Z and C gilts within each replicate. Mean serum concentrations of LH were suppressed (P = .025) during consumption of Z (.25 vs .42 ng/ml) but were similar (P = .16) to concentrations in C gilts 1 wk after Z was withdrawn (.35 vs .45 ng/ml). Frequency and amplitude of LH secretory spikes did not differ (P greater than .50) between Z and C gilts during either sampling period. Mean serum concentrations of FSH were similar (P = .25) between Z and C gilts. Number of corpora lutea and live fetuses were similar (P = .29 and P = .94, respectively) between Z and C gilts. Fetal weights were greater (P = .025) and crown to rump length tended to be greater (P = .10) in fetuses from Z gilts.(ABSTRACT TRUNCATED AT 250 WORDS)

Alimentação de leitoas pré-púberes com dietas contendo aflatoxinas ou zearalenona

“…A exposição alimentar a concentrações de zearalenona maiores que as utilizadas neste trabalho (10 mg kg -1 ) não influenciou a conversão alimentar e o ganho de peso em leitoas pré-púberes (Green et al, 1990). A zearalenona também não altera a digestibilidade de dietas nem o metabolismo protéico ou energé-tico de suínos (Hauschild et al, 2007).…”

Alimentação de leitoas pré-púberes com dietas contendo zearalenona

“…Isso pode ser explicado porque, nessa concentração, a ZEA não altera a digestibilidade das dietas e os metabolismos protéico e energético de suínos (Hauschild et al, 2007). A exposição oral a doses mais altas de ZEA (10mg kg -1 ) também não influenciou a conversão alimentar e o ganho de peso de leitoas pré-púberes (Green et al, 1990 Algumas alterações nos metabolismos protéico e energético foram descritas em ratos alimentados com dietas contendo níveis elevados de ZEA (Nogowski, 1996;Szkudelska, 2002 A evolução do volume vulvar é apresentada na Fig. 1.…”

“…Em trabalho semelhante, foi observado aumento no volume vulvar de leitoas alimentadas com dietas contendo 2mg kg -1 de ZEA após uma semana de consumo (Rainey et al, 1990). Em concentrações mais elevadas (de 10mg kg -1 de ZEA), os sinais de hiperestrogenismo são percebidos após três dias de consumo (Green et al, 1990). Devido ao aumento rápido do volume vulvar observado neste estudo e em outros relatos de contaminação de dietas com ZEA, o monitoramento desse órgão pode ser uma ferramenta importante para avaliar a atividade da micotoxina nos animais.…”

The role of mycotoxins in pig reproduction: a review

“…This results in heavily swollen vulva in one day old female piglets. Experimental administration of feed containing 10 ppm zearalenone has been shown to have no impact on ovulation or on the nidated fetuses (Etienne and Jemmali, 1982;Edwards et al, 1987a;Green et al, 1990;Rainy et al, 1990). Similarly, experimental administration of 9 ppm zearalenone in the feed during the entire duration of gestation had no impact on the number of piglets born or on the survival rate of the piglets (Etienne and Jemmali, 1982;Young and King, 1986).…”