Effect of prepubertal ovariohysterectomy on bone mineral density and bone mineral content in puppies

Ekici, Hayri; Sontas, BH; Toydemir, Tuğba Seval Fatma; Senmevsim, Ö.; Kabasakal, Levent; Imre, Y.

doi:10.1556/avet.53.2005.4.7

Cited by 12 publications

(13 citation statements)

References 29 publications

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“…The animals were taken outside in groups once daily for at least 4 h for exercise and play. Vaccination and deworming protocols used in this study were the same as previously reported (Ekici et al, 2005).…”

Section: Animals and Study Designmentioning

confidence: 99%

“…The surgeries were performed at 10 weeks of age under isoflurane (Isoflurane, Rhodia Organique Fine Ltd., UK) anaesthesia following premedication with atropine (0.04 mg/kg SQ, Atropin, Vetaş, Turkey) and carprofen (4 mg/kg SQ, Rimadyl, Pfizer, Belgium) in the same manner as previously described (Ekici et al, 2005). Group I consisted of 11 animals that were completely ovariohysterectomised using the technique described by Howe and Olson (2000), Group II consisted of 10 animals that were incompletely ovariohysterectomised, leaving the left ovary intact, and Group III consisted of 10 animals that had a sham surgery.…”

Section: Surgeriesmentioning

confidence: 99%

“…In our previous study (Ekici et al, 2005) we investigated the changes in bone mineral density and bone mineral content of the calcaneus and the accessory carpal bone after prepubertal ovariohysterectomy using dual energy X-ray absorptiometry. No differences were found between puppies that underwent prepubertal ovariohysterectomy or sham surgery.…”

mentioning

confidence: 99%

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Short-term effects of prepubertal ovariohysterectomy on skeletal, physical and behavioural development of dogs up to 24 weeks of age

Ekici

2007

Acta Veterinaria Hungarica

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This study investigated the effects of ovariohysterectomy performed at 10 weeks of age on body weight, behaviour, bone length, serum calcium and phosphorus concentrations and gonadal hormone (progesterone and oestradiol) levels until 24 weeks of age in 31 clinically healthy mixed-breed female puppies. The littermates were randomly assigned to three groups. Group I (n = 11) was completely ovariohysterectomised, Group II (n = 10) was incompletely ovariohysterectomised with one ovary left intact, and Group III (n = 10) was sham operated. No significant differences were found between the groups for any of the parameters evaluated. It was determined that, except for two measurements of two animals in Group II at 20 and 24 weeks of age, all animals had undetectable concentrations of oestradiol 17-β. These findings suggest that an ovariohysterectomy performed on a mixed-breed dog at 10 weeks of age does not affect her skeletal, behavioural or physical development in the period studied, i.e. until 24 weeks of age.

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Section: Animals and Study Designmentioning

confidence: 99%

Section: Surgeriesmentioning

confidence: 99%

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Short-term effects of prepubertal ovariohysterectomy on skeletal, physical and behavioural development of dogs up to 24 weeks of age

Ekici

2007

Acta Veterinaria Hungarica

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“…Ovariohysterectomy is the safest and most effective treatment for pyometra 11,12 and it is a radical treatment for postoestrus metritis when it recurs following failure of medical treatment and also that is, sterilisation, as many owners complain of the manifestations of heat with vulvular discharge, as well as the problems associated with repeated mattings 13 and finally, ovariohysterectomy is a tool used for combating pet overpopulation 14 .…”

Section: Discussionmentioning

confidence: 99%

Experimental ovarian transplantation on stomach for bone repair in ovariohysterectomized rabbits

et al. 2013

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PURPOSE:To evaluate the bone repair process in ovariohysterectomized rabbit submitted to an ovarian transplant to stomach that may supplying some quantity of estrogen occurs to improve bone healing. METHODS:In 20 female rabbits three holes of 1, 2 and 3mm diameter in tibial shaft were made and after that all animals received OHE through a ventral incision and they were randomly divided into two groups of ten rabbits each. In group one, animals received one of their self-ovaries that transplanted on serosal layer of stomach and group two did not receive treatment. Animals were kept during bone healing for a period of 45 days and radiological, biochemical, biomechanical and histopathological evaluation. RESULTS:The tibial defects in group one healed completely after 45 days and had more callous than second group. There is significant difference between two groups after operation in 21, 28 and 35 days about estrogen, progesterone and phosphatase Alkaline. The maximum forces in group one, were significantly higher than that for the group two. CONCLUSION:Ovarian transplantation prevents the effects of ovariohysterectomized on bone healing of rabbit tibia, suggesting that unilateral transplanted ovaries can substitute for the action of ovaries on the skeleton in ovariohysterectomized animals.

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“…It is well-known that OVX mice present a reduced bone mass and quality with significantly decreased BMD and bone mineral content (BMC) [44]. Based on the in vitro study, the antiosteoporotic effects of KB in OVX mice was investigated.…”

Section: Kb Inhibited Bmd Loss In Ovx Micementioning

confidence: 99%

Anti-Osteoporotic Effects of Kukoamine B in Osteoblast and Osteoclast Cells and Ovariectomized Mice

Park¹,

J²,

Kim³

et al. 2017

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Abstract:Osteoporosis is an abnormal bone remodeling condition characterized by decreased bone density, which leads to high risks of broken bones. Previous studies have demonstrated that Lycii Radicis Cortex (LRC) extract inhibits bone loss in ovariectomized (OVX) mice by enhancing the osteoblast differentiation. A bioactive compound, Kukoamine B (KB), was identified from a fractionation of LRC extract as a candidate component responsible for an anti-osteoporotic effect. This study investigated the anti-osteoporotic effects of KB using in vitro and in vivo osteoporosis models. KB treatment significantly increased the osteoblastic differentiation and mineralized nodule formation of osteoblastic MC3T3-E1 cells, while it significantly decreased the osteoclast differentiation of primary-cultured monocytes derived from mouse bone marrow. The effects of KB on osteoblastic and osteoclastic differentiations under more physiological conditions were also examined. In the co-culture of MC3T3-E1 cells and monocytes, KB promoted osteoblast differentiation but did not affect osteoclast differentiation. For the in vivo experiments, KB significantly inhibited OVX-induced bone mineral density loss and restored the impaired bone structural properties in osteoporosis model mice. These results suggest that KB may be a potential therapeutic candidate for the treatment of osteoporosis.

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Effect of prepubertal ovariohysterectomy on bone mineral density and bone mineral content in puppies

Cited by 12 publications

References 29 publications

Short-term effects of prepubertal ovariohysterectomy on skeletal, physical and behavioural development of dogs up to 24 weeks of age

Short-term effects of prepubertal ovariohysterectomy on skeletal, physical and behavioural development of dogs up to 24 weeks of age

Experimental ovarian transplantation on stomach for bone repair in ovariohysterectomized rabbits

Anti-Osteoporotic Effects of Kukoamine B in Osteoblast and Osteoclast Cells and Ovariectomized Mice

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