Effect of Pretransplant Dialysis Modality on Outcomes After Simultaneous Pancreas-Kidney Transplantation

Räihä, Juulia; Helanterä, Ilkka; Ekstrand, Agneta; Nordin, Arno; Sallinen, Ville; Lempinen, Marko

doi:10.12659/aot.916649

Cited by 11 publications

(15 citation statements)

References 26 publications

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“…Simultaneous pancreas-kidney transplantation (SPK) has established its importance as endocrine replacement therapy for patients with type 1 diabetes and end-stage kidney disease 1,2 . However, severe postoperative complications still negatively affect both short-and long-term outcomes [3][4][5] .…”

Section: Introductionmentioning

confidence: 99%

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First‐day plasma amylase detects patients at risk of complications after simultaneous pancreas‐kidney transplantation

Bonsdorff

Sallinen

Räihä

et al. 2021

Clinical Transplantation

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Section: Introductionmentioning

confidence: 99%

“…1,2 However, severe postoperative complications still negatively affect both short-and long-term outcomes. [3][4][5] Majority of the complications are related to the pancreas allograft and include hemorrhage, vascular thrombosis,…”

mentioning

confidence: 99%

First‐day plasma amylase detects patients at risk of complications after simultaneous pancreas‐kidney transplantation

Bonsdorff

Sallinen

Räihä

et al. 2021

Clinical Transplantation

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“…[20]. In contrast to that, other studies reported no difference in surgical outcome between HD and PD patients after SPKT [21][22][23][24].…”

Section: Impact Of Demographical and Clinical Variablesmentioning

confidence: 87%

Impact of pre-transplant dialysis modality on the outcome and health-related quality of life of patients after simultaneous pancreas-kidney transplantation

Scheuermann

Rademacher

Jahn

et al. 2020

Preprint

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Background Simultaneous pancreas-kidney transplantation (SPKT) profoundly improves the Health-related quality of life (HRQoL) of the recipients. However, the influence of the pre-transplant dialysis modality on the success of the SPKT and post-transplant HRQoL is still unknown. Methods We analyzed the surgical outcome, long-term survival, as well as HRQoL of 83 SPKTs that were performed between 2000 and 2016 in our Hospital. Prior to transplant, 63 patients received hemodialysis (HD) and 19 patients received peritoneal dialysis (PD). Physical and mental quality of life results from eight basic scales and the physical and mental component summaries (PCS and MCS) were measured using the Short Form 36 (SF-36) survey. Results Peri- and postoperative complications, as well as patient and graft survival were similar in both groups. Both groups showed improvement of HRQoL in all SF-36 domains after transplantation. Compared to patients who received HD before transplantation, PD-patients showed significantly better results in five of the eight SF-36 domains: physical functioning (P = 0.02), bodily pain (P = 0.001), general health (P = 0.038), vitality (P = 0.014), role limitations emotional (P = 0.048) and PCS (P = 0.002) after SPKT. In the overall study population, graft loss was associated with significant worsening of the HRQoL in all physical components (each P < 0.01). Conclusions The results of this analysis show that pre-transplant dialysis modality has no influence on outcome and survival rate after SPKT. Regarding HRQoL, patients receiving PD prior to SPKT seems to entail a slight advantage compared to patients with HD before transplantation.

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“…Martins et al reported a significantly higher rate of pancreas loss due to infection among PD patients after SPKT (HD: 3.4% versus PD: 12.8%; P = 0.042), whereas ten out of 39 (25.6%) PD patients had peritonitis in their past [20]. By contrast, other studies have reported no difference in surgical outcome between HD and PD patients after SPKT [21][22][23][24]. Our analysis could not reveal significant differences in intraabdominal infection rates after SPKT between the two groups, and there was no correlation between the incidence of pre-transplant peritonitis and post-transplant intra-abdominal infection.…”

Section: Discussionmentioning

confidence: 97%

Impact of pre-transplant dialysis modality on the outcome and health-related quality of life of patients after simultaneous pancreas-kidney transplantation

Scheuermann

Rademacher

Jahn

et al. 2020

Health Qual Life Outcomes

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Background Simultaneous pancreas-kidney transplantation (SPKT) profoundly improves the health-related quality of life (HRQoL) of recipients. However, the influence of the pre-transplant dialysis modality on the success of the SPKT and post-transplant HRQoL remains unknown. Methods We analyzed the surgical outcome, long-term survival, as well as HRQoL of 83 SPKTs that were performed in our hospital between 2000 and 2016. Prior to transplant, 64 patients received hemodialysis (HD) and nineteen patients received peritoneal dialysis (PD). Physical and mental quality of life results from eight basic scales and the physical and mental component summaries (PCS and MCS) were measured using the Short Form 36 (SF-36) survey. Results Peri- and postoperative complications, as well as patient and graft survival were similar between the two groups. Both groups showed an improvement of HRQoL in all SF-36 domains after transplantation. Compared with patients who received HD before transplantation, PD patients showed significantly better results in four of the eight SF-36 domains: physical functioning (mean difference HD - PD: − 12.4 ± 4.9, P = < 0.01), bodily pain (− 14.2 ± 6.3, P < 0.01), general health (− 6.3 ± 2.8, P = 0.04), vitality (− 6.8 ± 2.6, P = 0.04), and PCS (− 5.2 ± 1.5, P < 0.01) after SPKT. In the overall study population, graft loss was associated with significant worsening of the HRQoL in all physical components (each P < 0.01). Conclusions The results of this analysis show that pre-transplant dialysis modality has no influence on the outcome and survival rate after SPKT. Regarding HRQoL, patients receiving PD prior to SPKT seem to have a slight advantage compared with patients with HD before transplantation.

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Effect of Pretransplant Dialysis Modality on Outcomes After Simultaneous Pancreas-Kidney Transplantation

Cited by 11 publications

References 26 publications

First‐day plasma amylase detects patients at risk of complications after simultaneous pancreas‐kidney transplantation

First‐day plasma amylase detects patients at risk of complications after simultaneous pancreas‐kidney transplantation

Impact of pre-transplant dialysis modality on the outcome and health-related quality of life of patients after simultaneous pancreas-kidney transplantation

Impact of pre-transplant dialysis modality on the outcome and health-related quality of life of patients after simultaneous pancreas-kidney transplantation

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