This investigation aims to develop a novel infrared drying system and optimization of ultrasound-assisted osmotic dehydration of garlic slices. RSM and ANN approaches are used for modeling and optimization of the process parameters. The factors sonication time, sonication temperature, and osmotic concentration, were considered to optimize responses, that is, solid gain (SG), weight loss (WL), rehydration ratio (RR), drying rate (DR), and allicin content (AC). The ultrasonic time and osmotic concentration had significant effects on mass transfer parameters and the quality of dried garlic slices. The optimum drying conditions were found at an ultrasonic temperature: