Effect of probiotic acidophilus plus against infection with secondary hydatid disease in BALB /c mice

Yousif, S. Y.; Ali, Asmaa A.

doi:10.33899/ijvs.2019.125613.1104

Cited by 9 publications

(7 citation statements)

References 28 publications

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“…It may well be concluded that probiotic bacteria can be used as a therapeutic method against hydatidosis. Unfortunately, no immune analysis was done ( Yousif and Ali 2020 ).…”

Section: Probiotics As Complement/treatment Against Helminth Infectionsmentioning

confidence: 99%

Searching for the one(s): Using Probiotics as Anthelmintic Treatments

Saracino¹,

Vila²,

Baldi³

et al. 2021

Front. Pharmacol.

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Helminths are a major health concern as over one billion people are infected worldwide and, despite the multiple efforts made, there is still no effective human vaccine against them. The most important drugs used nowadays to control helminth infections belong to the benzimidazoles, imidazothiazoles (levamisole) and macrocyclic lactones (avermectins and milbemycins) families. However, in the last 20 years, many publications have revealed increasing anthelmintic resistance in livestock which is both an economical and a potential health problem, even though very few have reported similar findings in human populations. To deal with this worrying limitation of anthelmintic drugs, alternative treatments based on plant extracts or probiotics have been developed. Probiotics are defined by the Food and Agriculture Organization as live microorganisms, which, when consumed in adequate amounts, confer a health benefit to the host. It has been proven that probiotic microbes have the ability to exert an immunomodulatory effect both at the mucosa and the systemic level. The immune response against gastrointestinal helminths is characterized as a type 2 response, with high IgE levels, increased numbers and/or activity of Th2 cells, type 2 innate lymphoid cells, eosinophils, basophils, mast cells, and alternatively activated macrophages. The oral administration of probiotics may contribute to controlling gastrointestinal helminth infections since it has been demonstrated that these microorganisms stimulate dendritic cells to elicit a type 2 or regulatory immune response, among other effects on the host immune system. Here we review the current knowledge about the use of probiotic bacteria as anthelmintic therapy or as a complement to traditional anthelmintic treatments. Considering all research papers reviewed, we may conclude that the effect generated by probiotics on helminth infection depends not only on the parasite species, their stage and localization but also on the administration scheme.

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“…It may well be concluded that probiotic bacteria can be used as a therapeutic method against hydatidosis. Unfortunately, no immune analysis was done ( Yousif and Ali 2020 ).…”

Section: Probiotics As Complement/treatment Against Helminth Infectionsmentioning

confidence: 99%

Searching for the one(s): Using Probiotics as Anthelmintic Treatments

Saracino¹,

Vila²,

Baldi³

et al. 2021

Front. Pharmacol.

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“…Diagnosis of cystic echinococcosis is based on imaging techniques, like ultrasound as a major tool for classification of hydatid cysts (6). Whereas serological methods were used for confirmation only (7). Ultrasound is a physical and therapeutic method as non-ionizing radiation in the form of mechanical sound waves to the tissues to raise the temperature.…”

Section: Introductionmentioning

confidence: 99%

Effect of ultrasound on protoscoleces of Echinococcus granulosus in vitro and in vivo

Ali¹,

Ramadhan²

2021

IJVS

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The current study was designed to investigate the effect of ultrasound on the protoscoleces of Echinococcus granulosus by enforcing steady numeral of frequencies during a certain interval (20000 pulse/s) (1.8 w/cm 2 ), using exposure time 30,20,15,12,10 and 5s, individually and respectively. Consequently, six albino mice groups were immunized against cystic echinococcosis, which injected with exposed protoscoleces, to acquire specific cell-mediated immunity, called delayed type-hypersensitivity (DTH) which assessment by measurement the foot pad density. The results displayed significant excess (P≤ 0.001) of DTH by increase of foot pad thickness in injected groups. The results showed maximum thickness of 1.54 mm, 1.4mm, 0.9 mm. after 3h, 24h, and 48h postinjection, respectively, that compared with the thickness of control group 1.072, 0.638, 0.328 mm, respectively, during five months of experiment. The present research exhibited the action of ultrasonication technique on the viability of Echinococcus granulosus protoscoleces in vitro. Conclusion, Ultrasound frequencies used in the present study could be have consequential impact on the cellular immunity in albino mice.

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“…The intermediated host can be infected by orally ingestion of parasite eggs which develop into fluid-filled cysts in their liver, lungs, and other organs [4]. The disease causes expanded mortality and morbidity in human and livestock [5]. Echinococcosis disease is asymptomatic for several years, and the clinical symptoms can appear due to increase of cyst size which cause pressure on nearby tissues [6].…”

Section: Introductionmentioning

confidence: 99%

Effect of Saussurea costus extracts in the viability of Echinococcus granulosus protoscoleces of sheep origin In vitro

Al-obaidy¹,

Esmaeel²

2021

J.Edu.Sci.

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Cystic echinococcosis is one of the most prevalence and dangerous zoonotic parasitic disease in the world. Iraq is one of the most countries that affected by this disease. Surgery is usually the most effective therapy and can be used with injection of drugs in hydatid cysts before surgery to kill protoscoleces to avoid anaphylactic shock as a result of spilling of hydatid cyst fluid into peritoneal cavity, as well as this reduce the chance of secondary hydatid cysts production. Therefore, the current study aimed to evaluate the effectiveness of Saussurea costus extracts on protoscoleces viability of Echinococcus granulosus , where the protoscoleces of E. granulosus exposed to four different concentrations of Saussurea costus extracts at four different exposure times including; 15, 30, 45 and 60 min in vitro, The results of ethanolic extract showed highest efficacy at concentration 20,30mg/ml in 45,60min and 40mg/ml at all times. The highest scolicidal effect of petroleum ether extract was reported at 10 and 15mg/ml during 60min, while 20mg/ml reported similar effect at 45 and 60min. The data of cool aqueous extract showed reduction of protoscoleces viability to 0% at 200 and 250mg/ml in 45 and 60min, respectively, while 300mg/ml showed same reduction of viability at all experiment time periods. The data of hot aqueous extract showed 100% kill rate by using 350mg/ml at 60min and 400mg/ml at 45 and 60, as well as 450mg/ml at all experiment period times. Comparing to the control group. Generally, Saussurea costus extracts have concentration and exposure time-dependent effect on protoscoleces viability.

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Effect of probiotic acidophilus plus against infection with secondary hydatid disease in BALB /c mice

Cited by 9 publications

References 28 publications

Searching for the one(s): Using Probiotics as Anthelmintic Treatments

Searching for the one(s): Using Probiotics as Anthelmintic Treatments

Effect of ultrasound on protoscoleces of Echinococcus granulosus in vitro and in vivo

Effect of Saussurea costus extracts in the viability of Echinococcus granulosus protoscoleces of sheep origin In vitro

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