Effect of Probiotic Supplementation on Depression and Anxiety

Parhizgar, Nazanin; Azadyekta, Mehrnaz; Zabihi, Reza

doi:10.32598/cmja.11.2.1073.1

Cited by 3 publications

(1 citation statement)

References 14 publications

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“…It includes periods in which a person's mood becomes very despondent, so the basic element is boredom [ 4 ]. Depression can also be associated with other disorders such as alcohol dependence, sleep, eating, and some personality disorders [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Potential role of gut microbiota in major depressive disorder: A review

Khaledi,

Sameni,

Gholipour

et al. 2024

Heliyon

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Section: Introductionmentioning

confidence: 99%

Potential role of gut microbiota in major depressive disorder: A review

Khaledi,

Sameni,

Gholipour

et al. 2024

Heliyon

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Adjuvant administration of probiotic effects on sexual function in depressant women undergoing SSRIs treatment: a double-blinded randomized controlled trial

Hashemi-Mohammadabad,

Taghavi,

Lambert

et al. 2024

BMC Psychiatry

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Background According to the Institute of Health Metrics and Evaluation’s Global Health Data Exchange (2023) it is estimated that 5% of all adults will experience depressive disorder. Amongst the general loss of pleasure and interest in everyday activities that are symptoms of low mood, reduced sexual desire and sexual dysfunction can be particularly overlooked. Human sexuality is complex, but finding solutions based on scientific evidence to limit the symptoms of depressive disorder and the iatrogenic impact of antidepressant treatment to improve this outcome is an important step in promoting psychological health and general wellbeing. Objective The present study aimed is to provide scientific evidence to assess the effect of oral probiotic on sexual function in women with depressive disorder treated with Selective Serotonin Reuptake Inhibitors (SSRIs) in an Iranian population. Design This study was a double-blind randomized clinical trial. Eligible women were assigned to lactofem plus SSRIs (n = 58) or SSRIs alone (n = 54). In group A, SSRI antidepressants were prescribed together with Lactofem, and in group B, SSRI antidepressants were prescribed alone. Lactofem including Lactobacillus acidophilus 2 × 109 cfu/g, Bifidobacterium bifidus 2 × 109 cfu/g, Lactobacillus rutri 2 × 109 cfu/g, Lactobacillus fermentum 2 × 109 cfu/g; capsule weight of 500 mg bio-capsule administered orally and daily. The duration of intervention in two groups was two months. All questionnaires were completed by the patients before and after the intervention. The Female Sexual Function Index (FSFI), Hamilton Depression Rating Scale and Larson's Sexual Satisfaction Questionnaire were used to evaluate sexual function, severity of depressive disorder and sexual satisfaction, respectively. Results Based on the results of the present study, there was a statistically significant difference in sexual satisfaction and severity of depressive disorder between the groups before and after the intervention (P < 0.05). Also, our findings showed that after eight weeks, the Lactofem plus SSRIs group showed significant improvement in FSFI domains and total scores compared to SSRIs alone group (P < 0.05). Conclusions The results of the present study show that taking probiotics for eight weeks may improve the severity of depressive disorder, sexual function and sexual satisfaction in depressed women treated with SSRIs. Trial registration ClinicalTrials.govidentifier: IRCT20160524028038N14 (19/12/2022)

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Investigating the Effect of Oral Probiotic Capsules on Postpartum Quality of Sleep in Primiparous women: A Three-blind Randomized Control trial

Rastegar,

Shoorab,

Salari

et al. 2024

Preprint

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Introduction : Quality of sleep is an important indicator of health. Sleep disturbance and daytime fatigue is one of the most common problems after delivery. Early postpartum (first 4 weeks) is when sleep is most disturbed. The gut microbiota may affect sleep quality and affect host health through the production of metabolites and compounds. The present study aims to determine the effect of oral probiotic capsule on the quality of sleep after delivery in primiparous women. Method This three-blind randomized clinical trial study was conducted in August to November 2023 on 60 eligible primiparous women who gave birth in Mashhad, Iran health centers. The drug group (n = 30) took one probiotic capsule (containing Lactobacillus acidophilus, Bifidobacterium-Bifidum, Bifidobacterium lactis and Bifidobacterium longum) and the placebo group (n = 30) took a placebo capsule from the third day after delivery for 30 days. The Pittsburg Sleep Quality questionary was completed before and after the study. The analysis was done using SPSS version 25 statistical software. Kolmogorov-Smirnov and Shapiro-Wilk tests, T-test and Mann-Whitney test were used. The p-value of less than 0.05 was considered significant. Results The two groups were homogeneous in terms of demographic and obstetric characteristics except in BMI. Before the intervention, the overall score of postpartum quality of sleep in the drug and placebo groups was 9.66 ± 6.21 and 11.70 ± 6.68, and after the intervention in the probiotic group was 6.16 ± 2.75 and in the placebo group it was 6.60 ± 2.66 with a statistically significant difference in the intervention group compared to the placebo (p < 0.05). Conclusion Consumption of probiotic capsules improves the quality of sleep and maternal health in the postpartum period.

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Effect of Probiotic Supplementation on Depression and Anxiety

Cited by 3 publications

References 14 publications

Potential role of gut microbiota in major depressive disorder: A review

Potential role of gut microbiota in major depressive disorder: A review

Adjuvant administration of probiotic effects on sexual function in depressant women undergoing SSRIs treatment: a double-blinded randomized controlled trial

Investigating the Effect of Oral Probiotic Capsules on Postpartum Quality of Sleep in Primiparous women: A Three-blind Randomized Control trial

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