Effect of probiotic supplementation on immunoglobulins, isoagglutinins and antibody response in children of low socio-economic status

Pérez, Nicolas; Iannicelli, Juan C.; Girard-Bosch, Cecilia; Gonzalez, Silvia Nelina; Varea, Ana; Disalvo, Liliana; Apezteguía, María; Pernas, Juan Carlos; Vicentin, Dimas; Cravero, Ricardo

doi:10.1007/s00394-009-0063-5

Cited by 36 publications

(35 citation statements)

References 18 publications

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“…We believe that the socioeconomic status and genetic background may explain the results. (9) Acomparison between two cities in São Paulo state showed high titers for both men and women with an increase in levels in recent years. (10) The authors did not stratify for age and the technique used for titration was not mentioned.…”

Section: Discussionmentioning

confidence: 99%

Titers of ABO antibodies in group O blood donors

França¹,

Poli²,

Ramos³

et al. 2011

Rev. Bras. Hematol. Hemoter.

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BackgroundPlasma components of group O blood donations are rarely submitted to ABO antibody titrations even though it is well known that passively acquired antibodies may destroy the recipient's own red cells and tissue grafts.ObjectiveThus, group O donations stratified by gender and age were randomly titrated to identify the best source of products for apheresis and exsanguinous transfusion.MethodsSamples from 603 blood donors were tested by ABO antibody titration using the conventional tube technique at room temperature. ABO antibody levels higher than 64 were considered high. After correction for gender, statistical analyses were performed using the Fisher exact and Kruskal-Wallis tests.ResultsMost donors in the blood bank were male (65.7%). ABO antibody titers ranged from 1 to 2048. The estimations of prevalence for the titers were: anti-A,B < 128 = 86.9% and = 128 = 2.16%; Anti-A = 128 = 9.29% and anti-B = 128 = 4.81%. Low mean titers for both anti-A and anti-B antibodies were found in over 50-year-old men (p-value = 0.040). High anti-B antibody levels were found in young women (p-value = 0.002).ConclusionThis study confirms that over 50-year-old O group men should be selected as blood donors in non-identical ABO transfusion situations. Also, titration of ABO antibodies in blood banks will increase safety in non-identical ABO transfusions.

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Section: Discussionmentioning

confidence: 99%

Titers of ABO antibodies in group O blood donors

França¹,

Poli²,

Ramos³

et al. 2011

Rev. Bras. Hematol. Hemoter.

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“…This may suggest that when there is an adequate immune response, the probiotics have no additive effect on the quantity of antibodies produced, but that their value lies in a boosting effect only for infants with a weak immunological response to vaccination. Prior studies have shown that infants in developing countries usually mount higher antibody titres following vaccination, than do infants from developed countries 23. This has been explained by the ‘hygiene hypothesis’ stating that early repeated antigenic stimulation by viral and bacterial infections stimulates a Th1 profile of the immune response, favouring IgG2 production.…”

Section: Discussionmentioning

confidence: 99%

“…Improvements in public health and hygiene, and the steady decline in family size in the developed world can thus potentially favour a Th2 response, explaining the reduced ability to mount adequate antibody responses following exposure to infections or vaccination 9 14 24. Accordingly, Pérez et al 23 showed recently that probiotic supplementation has no effect on antibody responses following DTP-Hib and 23-valent pneumococcal vaccine in children of low socioeconomic status in Argentina. It is possible that probiotic supplementation is a safe way of ‘closing the gap’ between infants in developed countries and those from developing parts of the world, regarding early microbial colonisation and antigenic stimulation.…”

Section: Discussionmentioning

confidence: 99%

Probiotics and the immunological response to infant vaccinations: a prospective, placebo controlled pilot study

Youngster

Kozer

Lazarovitch

et al. 2011

Archives of Disease in Childhood

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Background Probiotics have been shown to be immunomodulatory and can affect antibody responses following vaccination. Several immunisations are associated with suboptimal seroconversion rates leaving a substantial part of the population exposed to infection. Objectives To evaluate the infl uence of probiotic supplementation on the immune response of infants following mumps, measles, rubella and varicella vaccination. Methods A randomised, placebo-controlled, double blinded prospective trial was performed in a cohort of healthy infants. Study subjects were randomly assigned to receive probiotics or placebo for a total of 5 months, starting 2 months prior to vaccination. Antibody levels against vaccine components were measured 3 months after immunisation. Treatment-related and vaccinerelated adverse events were recorded. Findings 47 infants completed the study, 25 in the probiotic group and 22 in the placebo group. There was no statistically signifi cant difference in the number of infants failing to reach protective antibody titres against the different vaccine components (three infants in the placebo group against one in the treatment group for rubella, two each for mumps, four children vs two for measles). When combining all results in both groups, a larger percentage of failures to seroconvert occurred in the placebo group (17% vs 8%, p=0.052), a result of borderline signifi cance. The number of infants needed to treat in order to prevent one failed vaccine component was 12. There was no difference in the rate of treatment related adverse effects between the two groups. There was a signifi cant trend toward fewer vaccine related adverse effects in the treatment group. Conclusions Oral probiotics given to infants during the period of immunisation do not interfere with the immune response to mumps, measles, rubella and varicella vaccine, and may improve seroconversion rates.

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“…A yogurt of a lot provided for the volunteers was randomly tested six days after its expiration date, in which a bifidobacteria concentration of 1.74x10 6 CFU/g of yogurt was found. Coupled with the likely concentration of Lactobacillus, this would still be a probiotic food and bring benefits to people's health (19) , including celiac patients.…”

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confidence: 99%

“…The maintenance of pH values before and after probiotic ingestion may be related to time or quantity/concentration of the daily-consumed probiotic, being suggested that probiotic effects are dose-dependent (19) . However, the recommended dose by the literature was consumed in this study, which is between 10 6 e 10 11 CFU/day, depending on the desired effect (22) .…”

mentioning

confidence: 99%

Effects of Probiotic Intake on Intestinal Bifidobacteria of Celiac Patients

Martinello

Roman

Souza

2017

Arq. Gastroenterol.

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-Background -Healthy individuals exhibit a significantly higher concentration of faecal bifidobacteria in comparison to celiac patients.Even though there are potential benefits in probiotic usage, they have been little explored as an adjunctive therapy in celiac disease. Objective -This study aimed at the comparison of faecal bifidobacteria concentration and pH among celiac patients and healthy subjects before and after the daily intake of 100 g of yogurt containing probiotic for a thirty-day period. Methods -Feces from 17 healthy subjects and 14 celiac patients were analyzed, in which stool culture was performed for the isolation and quantification of faecal bifidobacteria. Furthermore, Gram's method was employed for the microscopic analysis of the colonies, while the identification of the Bifidobacterium genus was made through determination of the fructose-6-phosphate phosphoketolase enzyme. Faecal pH was measured using a calibrated pHmeter. Results -Faecal bifidobacteria concentration before probiotic consumption was significantly higher in healthy individuals (2.3x10 8 ±6.3x10 7 CFU/g) when compared to celiac patients (1.0x10 7 ±1.7x10 7 CFU/g). Faecal pH values did not show a significant difference. After the daily consumption of probiotic-containing yogurt both groups showed a significant increase in the concentration of faecal bifidobacteria, but healthy subjects presented significantly higher bifidobacteria concentrations (14.7x10 8 ±0.2x10 8 CFU/g) than the celiac group (0.76x10 8 ±0.1x10 8 CFU/g). The obtained pH values from both groups were not significantly different, being 7.28±0.518 for the celiac patients and 7.07±0.570 for healthy individuals after the probiotic intake. Conclusion -The probiotic supplementation significantly increased the number of bifidobacteria in the feces of celiac patients, although it was not sufficient to reach the concentration found in healthy individuals prior to its consumption.

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Effect of probiotic supplementation on immunoglobulins, isoagglutinins and antibody response in children of low socio-economic status

Cited by 36 publications

References 18 publications

Titers of ABO antibodies in group O blood donors

Titers of ABO antibodies in group O blood donors

Probiotics and the immunological response to infant vaccinations: a prospective, placebo controlled pilot study

Effects of Probiotic Intake on Intestinal Bifidobacteria of Celiac Patients

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