Effect of probiotic supplementation on migraine prophylaxis: a systematic review and meta-analysis of randomized controlled trials

Parohan, Mohammad; Djalali, Mahmoud; Sarraf, Payam; Yaghoubi, Sajad; Seraj, Asal; Foroushani, Abbas Rahimi; Ranji-Burachaloo, Sakineh; Javanbakht, Mohammad Hassan

doi:10.1080/1028415x.2020.1764292

Cited by 16 publications

(5 citation statements)

References 35 publications

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“…Improvement [273] Magnesium Oral magnesium alleviates the frequency and intensity of migraine [274] Vitamin B2 Improvement [275] Folic acid with pyridoxine Decrease in headache severity [276] Probiotic No effect [277] Feverfew Low quality evidence for preventative effect [278] Butterbur Preventative effect [279] but possible health issues [280] Meditation Improved pain tolerance [281] Yoga Reduced headache frequency [282] Tai Chi Decreased stress in Chinese women with migraines [283] Melatonin Low quality evidence for improvement [284] Ginger Better treatment efficacy when used adjunctively with ketoprofen [285] Similar efficacy to drug sumatriptan [286] Omega 3 Reduction in duration [287] Ginkgolide B Reduction in migraine with aura frequency and duration [288] Limited evidence exists currently to make solid recommendations [289]. Riboflavin, magnesium and Coenzyme Q10 may reduce the pain severity from migraines [100].…”

Section: Interventionmentioning

confidence: 99%

Integrative Chronic Pain Management: A Narrative Review

Halma,

Marik,

Saleeby

et al. 2024

Preprint

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Many people in the USA have lost their lives or become addicted to opioids via prescription opioids given for chronic pain. The chronic pain epidemic has emerged due to a convergence of factors, including the medicalization of pain as well as injuries happening in the workplace, in the home, or during recreation. Opioid prescriptions rose precipitously from the late 1990’s through to approximately 2020, and despite public awareness, still are increasing. This review examines literature on integrative approaches to chronic pain as delineated by pain type. The review is organized by the most common causes of chronic pain, and randomized controlled trials, meta-analyses and systematic reviews are extracted for each cause of chronic pain. Several promising interventions may alleviate chronic pain of some causes, and some interventions may work across pain causes. Lowering inflammation through dietary or lifestyle regimens may be a general way of reducing pain. Pain can be alleviated through several adjunctive and integrative treatment approaches, which may serve to lower the need for opioid medication.

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Section: Interventionmentioning

confidence: 99%

Integrative Chronic Pain Management: A Narrative Review

Halma,

Marik,

Saleeby

et al. 2024

Preprint

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“…Fermented foods rich in probiotics include pickled vegetables and cultured dairy foods that contain live bacteria such as bifidobacteria and lactobacilli . The effect of probiotic supplementation on migraine prophylaxis was presented in a systematic review and meta-analysis of randomized controlled trials [76 ▪ ]. Three randomized controlled trials with 179 patients concluded that no significant effect was evident on the frequency and severity of migraine attacks.…”

Section: Dietary Approaches For Migrainementioning

confidence: 99%

Diet and migraine: what is proven?

Gazerani

2023

Current Opinion in Neurology

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Purpose of review The purpose of this review is to present the latest research findings about diet and migraine, what can be used in the clinic now, and what needs further investigation. Recent findings Recent findings highlight that dietary triggers exist for migraine, for example, coffee and alcohol, according to a new systematic review. Elimination diets must be personalized to delineate a balanced diet with acceptable quality and pattern. A piece of average-quality evidence shows that the ketogenic diet (KD) and the Dietary Approaches to Stop Hypertension (DASH) are effective in reducing the frequency, duration, and severity of migraine headaches in adult patients. The gut microbiome is altered in patients with migraine, and further research will identify the benefits of pre and probiotic use for migraine. Advanced digital technology in continuous monitoring can provide educational content based on patients’ needs, help patients adhere to dietary plans, and strengthen personalized care. The complex interaction of lifestyle factors, the influence of age and sex, and patients’ needs in various life phases are essential in formulating dietary plans. Summary The diet-migraine interaction is a dynamic bidirectional phenomenon that requires careful monitoring, review, and justification of dietary choices to yield the optimal outcome while minimizing potential risks.

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“…The number of abortive drugs used weekly for EM and daily for CM also decreased compared with baseline (EM: -0.72; p < 0.001; CM: -1.02; p < 0.001) and with no significant change in the placebo group [ 44 ]. However, a recent meta-analysis of published randomized clinical trials found insufficient evidence that probiotic supplementation significantly affects migraine frequency or severity, indicating that probiotics alone may be insufficient to restore microbiota alterations associated with migraine pathogenesis and that further research is warranted in this field [ 45 ].…”

Section: Evidence Linking Migraine and Gi Disordersmentioning

confidence: 99%

The Gut-brain Connection and Episodic Migraine: an Update

Nguyen,

Hindiyeh,

Ray

et al. 2023

Curr Pain Headache Rep

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Purpose of review Historical evidence suggests a shared underlying etiology for migraine and gastrointestinal (GI) disorders that involves the gut-brain axis. Here we provide narrative review of recent literature on the gut-brain connection and migraine to emphasize the importance of tailoring treatment plans for patients with episodic migraine who experience GI comorbidities and symptoms. Recent findings Recent population-based studies report the prevalence of migraine and GI disorders as comorbidities as well as overlapping symptomology. American Headache Society (AHS) guidelines have integrated GI symptoms as part of migraine diagnostic criteria and recommend nonoral therapies for patients with GI symptoms or conditions. Nasal delivery is a recommended nonoral alternative; however, it is important to understand potential adverse events that may cause or worsen GI symptoms in some patients due to the site of drug deposition within the nasal cavity with some nasal therapies. Lastly, clinical perspectives emphasize the importance of identifying GI symptoms and comorbidities in patients with episodic migraine to best individualize migraine management. Summary Support for an association between the gut-brain axis and migraine continues to prevail in recent literature; however, the relationship remains complex and not well elucidated. The presence of GI comorbidities and symptoms must be carefully considered when making treatment decisions for patients with episodic migraine.

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Effect of probiotic supplementation on migraine prophylaxis: a systematic review and meta-analysis of randomized controlled trials

Cited by 16 publications

References 35 publications

Integrative Chronic Pain Management: A Narrative Review

Integrative Chronic Pain Management: A Narrative Review

Diet and migraine: what is proven?

The Gut-brain Connection and Episodic Migraine: an Update

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