Effect of Probiotic Therapy on Neuropsychiatric Manifestations in Children with Multiple Neurotransmitter Disorders: A Study

Abstract

Probiotics, also known as psychobiotics, have been linked to cognitive functions, memory, learning, and behavior, in addition to their positive effects on the digestive tract. The purpose of this study is to examine the psychoemotional effects and cognitive functioning in children with gastrointestinal disorders who undergo psychobiotherapy. A total of 135 participants, aged 5–18 years, were divided into three groups based on the pediatrician’s diagnosis: Group I (Control) consisted of 37 patients (27.4%), Group II included 65 patients (48.1%) with psychoanxiety disorders, and Group III comprised 33 individuals (24.4%) with psychiatric disorders. The study monitored neurotransmitter levels such as serotonin, GABA, glutamate, cortisol, and DHEA, as well as neuropsychiatric symptoms including headaches, fatigue, mood swings, hyperactivity, aggressiveness, sleep disorders, and lack of concentration in patients who had gastrointestinal issues such as constipation, diarrhea, and other gastrointestinal problems. The results indicate that psychobiotics have a significant impact on reducing hyperactivity and aggression, and improving concentration. While further extensive studies are needed, these findings offer promising insights into the complexity of a child’s neuropsychic behavior and the potential for balancing certain behaviors through psychobiotics.

Variety of Serotonin Levels in Pediatric Gastrointestinal Disorders

“…At the same time, the presence of metabolic syndrome (MS) contributes to inflammation, increased susceptibility to infections [21,22], lower vitamin D levels [23], and a compromised immune response [24]. It is imperative to manage MS through the available approaches, including dietary therapy [25], probiotic therapy [26,27], and physical activity [28], as they represent essential means for addressing this complex health condition. In our study, we focused on pediatric patients while also addressing the complications associated with metabolic syndrome in this specific population.…”

“…Evidence of benefits in alleviating symptoms of depression and chronic fatigue syndrome are emerging. These benefits may be associated with the anti-inflammatory actions of certain psychobiotics and their capacity to reduce the activity of the hypothalamus-pituitary-adrenal axis [27,[49][50][51], with increasing clarity regarding their effectiveness. In our study, we monitored the progression of neuropsychiatric symptoms during probiotic treatment based on serotonin levels.…”