Effect of probiotics and synbiotics on blood glucose: a systematic review and meta-analysis of controlled trials

Nikbakht, Elham; Khalesi, Saman; Singh, Indu; Williams, Lauren; West, Nicholas P.; Colson, Natalie Jane

doi:10.1007/s00394-016-1300-3

Cited by 99 publications

(64 citation statements)

References 69 publications

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“…This is attributed to the modulation of the gut microbiota improves glucose absorption by producing insulinotropic polypeptides and glucagon‐like peptides (Nikbakht et al . ). Furthermore, other studies have observed that probiotics and synbiotics have nonsignificant effects on improving fasting blood glucose (Nikbakht et al .…”

Section: Synbiotic Cereal Beveragesmentioning

confidence: 97%

“…Furthermore, other studies have observed that probiotics and synbiotics have nonsignificant effects on improving fasting blood glucose (Nikbakht et al . ). Thus, there is a great potential to conduct trials with different probiotic bacteria and cereal prebiotics establish if there are potential synbiotic cereal beverages that significantly improve blood glucose.…”

Section: Synbiotic Cereal Beveragesmentioning

confidence: 97%

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Fermented cereal beverages: from probiotic, prebiotic and synbiotic towards Nanoscience designed healthy drinks

Salmerón

2017

Lett Appl Microbiol

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There is currently a great interest in producing healthy food in particular that which has an impact in improving the gastrointestinal health such as probiotics, prebiotics and synbiotics. Most of these functional foods are dairy based and have been greatly accepted worldwide. Nevertheless, there has been a need for the development of nondairy probiotic, prebiotic and synbiotic products. This has encouraged food scientists to study the feasibility of applying other fermenting substrates such as cereals for the development of innovative nondairy fermented functional foods. Therefore, in this review we have addressed the significance of applying cereals and their fractions for the development of probiotic, prebiotic and synbiotic beverages. Furthermore, we have presented the importance of including nanoscience and nanotechnology techniques for the creation of fermented cereal beverages that contain specific bioactive nanoparticles. Thus, this work provides the guidelines to promote the development of novel nano-designed fermented cereal beverages that could significantly have an impact on the health of the consumers.

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Section: Synbiotic Cereal Beveragesmentioning

confidence: 97%

Section: Synbiotic Cereal Beveragesmentioning

confidence: 97%

Fermented cereal beverages: from probiotic, prebiotic and synbiotic towards Nanoscience designed healthy drinks

Salmerón

2017

Lett Appl Microbiol

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“…The ability of probiotics to impart health benefits has prompted increased scientific interest for several decades. Evidence from animal and human studies has demonstrated potentially favourable benefits of probiotics, including modulating the number and diversity of beneficial gut microbiota (5,6); reducing symptoms associated with various GI disorders (7,8); improving blood cholesterol levels and blood lipid profile (9,10); removal of mycotoxins (11); reducing blood pressure and hypertension (12); improving blood glucose tolerance and diabetes control (13,14); and enhancing mental state and cognitive function (15).…”

Section: Introductionmentioning

confidence: 99%

A review of probiotic supplementation in healthy adults: helpful or hype?

et al. 2018

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Probiotic supplements have a positive impact on several health outcomes. However, the majority of published studies have focused on populations with specific health pathologies. Therefore, this study reviewed the current literature on the health effects of probiotic consumption in "healthy adults." The findings from this review may help guide consumers, researchers, and manufacturers regarding probiotic supplementation. Relevant literature published between 1990 and August 2017 was reviewed. Studies were included if they were experimental trials, included healthy adults, used live bacteria, and had accessible full-text articles published in English. Included studies were classified according to common foci that emerged. Forty-five studies were included in this review. Five foci emerged: gut microbiota changes (n = 15); immune system response (n = 16); lipid profile and cardiovascular disease risk (n = 14); gastrointestinal discomfort (n = 11); and female reproductive health (n = 4). Results suggest that probiotic supplementation in healthy adults can lead to transient improvement in gut microbiota concentration of supplement-specific bacteria. Evidence also supports the role of probiotics in improving immune system responses, stool consistency, bowel movement, and vaginal lactobacilli concentration. There is insufficient evidence to support the role of probiotics to improve blood lipid profile. Probiotic consumption can improve in the immune, gastrointestinal, and female reproductive health systems in healthy adults. However, this review failed to support the ability of probiotics to cause persistent changes in gut microbiota, or improve lipid profile in healthy adults. The feasibility of probiotics consumption to provide benefits in healthy adults requires further investigation.

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“…Several meta-analysis studies on results of clinical trials suggested that probiotic supplementation reduced the FPG, lipid profile, blood pressure, and other cardiovascular risk factors in T2D patients [49][50][51][52][53]. e probiotic supplements effectively controlled the glycemic and inflammatory status of GDM patients [30].…”

Section: Discussionmentioning

confidence: 99%

Do Probiotics Improve the Health Status of Individuals with Diabetes Mellitus? A Review on Outcomes of Clinical Trials

Kesika

Sivamaruthi

Chaiyasut

2019

BioMed Research International

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Probiotics are now considered as an adjuvant and complementary therapeutic agent for several health complications, especially for metabolic and gastrointestinal disorders because of the influential impact of probiotic consumption on gut microbiota and immunity. Diabetes mellitus (DM) is fourth, in noncommunicable disease category, leading cause of mortality, morbidity, and economic crises in the world. Though several progressions are added in the medical field in recent decades, the treatment and management of diabetic-related health issues are still challenging. The present study summarizes the effects of probiotic supplementation on the health status of diabetic patients. The relevant information was collected from Scopus, PubMed, and Google Scholar. The detailed literature survey revealed that the consumption of probiotic supplementation significantly improved the overall health condition of diabetic patients. Especially, the probiotic intervention improved the fasting blood glucose, insulin sensitivity, and systemic inflammatory and antioxidant status in type 2 diabetic (T2D) patients. Moreover, improvement of gut microbial composition and prevention of bacterial translocation has also been observed in probiotic-supplemented T2D people. Some of the studies evidenced that the supplementation of probiotics can prevent and improve the gestational DM. Nevertheless, some of the studies reported negative results and limitations in the results of clinical trials. However, further studies are mandatory to develop a concrete probiotic-based adjuvant treatment procedure to treat DM.

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Effect of probiotics and synbiotics on blood glucose: a systematic review and meta-analysis of controlled trials

Abstract: This meta-analysis suggests that probiotic and synbiotic supplementation may be beneficial in lowering FBG in adults with high baseline FBG (≥7 mmol/L) and that multispecies probiotics may have more impact on FBG than single species.

Cited by 99 publications

References 69 publications

Fermented cereal beverages: from probiotic, prebiotic and synbiotic towards Nanoscience designed healthy drinks

Fermented cereal beverages: from probiotic, prebiotic and synbiotic towards Nanoscience designed healthy drinks

A review of probiotic supplementation in healthy adults: helpful or hype?

Do Probiotics Improve the Health Status of Individuals with Diabetes Mellitus? A Review on Outcomes of Clinical Trials

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