Effect of probiotics on oxidative stress and inflammatory status in diabetic nephropathy: A systematic review and meta-analysis of clinical trials

Bohlouli, Jalal; Namjoo, Iman; Borzoo-Isfahani, Mohammad; Kermani, Mohammad Ali Hojjati; Zehi, Zakiyeh Balouch; Moravejolahkami, Amir Reza

doi:10.1016/j.heliyon.2021.e05925

Cited by 45 publications

(34 citation statements)

References 43 publications

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“…Therefore, MDA produced by lipid peroxidation can reflect the level of oxidative stress in the body [45]. In this study, MDA levels in the probiotic group was significantly reduced, which is in agreement with results from previous studies [36,[46][47][48][49]. Studies have shown that probiotics can change the lipid profile and the reduction in MDA may be due to an improvement in the lipid profile [50].…”

Section: Discussionsupporting

confidence: 91%

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A Pilot Study of the Effect of Lactobacillus casei Obtained from Long-Lived Elderly on Blood Biochemical, Oxidative, and Inflammatory Markers, and on Gut Microbiota in Young Volunteers

et al. 2021

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Probiotic intake has been shown to improve certain physiological health indicators. We aimed to examine effects of Lactobacillus casei LTL1879, obtained from long-lived elderly volunteers, on blood biochemical, oxidative, and inflammatory markers and gut microbiota in twenty healthy, young volunteers. Volunteers were randomly divided into equal probiotic and placebo groups and changes in blood biochemical indicators, oxidative and inflammatory markers, and gut microbiota were examined after three weeks of probiotic intervention. The probiotic group’s antioxidant levels were significantly enhanced post-intervention. Total antioxidant capacity (T-AOC) levels were significantly increased (p < 0.0001), while malondialdehyde (MDA) levels decreased (p < 0.05), and total superoxide dismutase (T-SOD) levels increased, but with no significant difference. In addition, Interleukin-10 (IL-10) and tumor necrosis factor-α (TNF-α) levels were significantly up-regulated and down-regulated (p < 0.05, respectively). Escherichia coli, Enterococcus, and Bacteroides expression was significantly reduced (p < 0.05), while Clostridium leptum, Bifidobacterium, and Lactobacillus expression increased (p < 0.05). Volunteer health status was quantified using principal components and cluster analysis, indicating that the probiotic group’s overall score was higher than that of the placebo group. The results of this pilot study suggest L. casei LTL 1879 can significantly improve specific immune, oxidative, and gut microbiota characteristics related to health factors.

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Section: Discussionsupporting

confidence: 91%

“…Normally, blood parameters and anthropometric measurements of healthy individuals are relatively stable. Studies have shown that the probiotic effect on volunteers' blood parameters and anthropometric measurements are related to baseline health status [35,36].…”

Section: Discussionmentioning

confidence: 99%

A Pilot Study of the Effect of Lactobacillus casei Obtained from Long-Lived Elderly on Blood Biochemical, Oxidative, and Inflammatory Markers, and on Gut Microbiota in Young Volunteers

et al. 2021

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“…However, LABs from camel milk are less explored for their health benefits. In mice [ 2 , 33 ], chicken [ 25 ], and humans [ 2 , 34 ], LAB probiotic strains have shown significant protection against a various number of infectious diseases [ 17 , 19 , 20 , 21 , 25 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 ]. Intranasal and oral pretreatment with LAB strains proved effective in protecting mice against influenza virus infection but did not protect against severe weight loss disease [ 43 , 44 ].…”

Section: Introductionmentioning

confidence: 99%

“…Intranasal and oral pretreatment with LAB strains proved effective in protecting mice against influenza virus infection but did not protect against severe weight loss disease [ 43 , 44 ]. Furthermore, various trials have shown that preventing a cold in healthy elders and extending the survival time for mice with influenza has shown positive results [ 2 , 19 , 35 , 45 ]. Many studies found that some novel probiotic isolates increase innate and acquired immunity [ 46 , 47 , 48 ], increasing antiviral defenses [ 25 , 43 , 44 , 46 ].…”

Section: Introductionmentioning

confidence: 99%

Potential Antiviral Activity of Lactiplantibacillus plantarum KAU007 against Influenza Virus H1N1

et al. 2022

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The development of antiviral resistance has exacerbated a growing threat to public health. As a result, there is increasing demand for unconventional antivirals that can effectively replace the presently in-use drugs. Lactic acid-producing bacteria (LAB) are among the most common bacteria used in the food industry. These bacteria play an essential role in the fermentation of many foods and feed. Additionally, these bacteria are considered more economical, efficient, and safe “nutraceuticals” in the health care arsenal. Therefore, we carried out the screening and molecular characterization of raw camel milk LAB isolates and tested their inhibitory activity against influenza virus H1N1. The strain that exhibited the highest antiviral activity against the H1N1 virus, confirmed by hemagglutination assay, was identified as Lactiplantibacillus plantarum KAU007. The study also confirmed the non-cytotoxic behavior of CFCS isolated from KAU007 against MDCK cells, approving its safety concern against the mammalian cells. Besides, CFCS at 5 and 10 mg/mL significantly decreased the level of IFN-γ (p < 0.001 and p < 0.001) and IL-6 (p < 0.001 and p < 0.005) in a dose-dependent manner, respectively. This is a preliminary report about the anti-influenza activity of KAU007 isolated from camel milk. This study reinforces that camel milk contains beneficial LAB isolates with antagonistic properties against the H1N1 influenza virus.

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“…Probiotics are live microorganisms which when administered in adequate amounts confer a health benefit to the host [6]. Clinical evidence shows that certain probiotics may help treat and prevent viral infections [7,8] due to the proven immunomodulatory activity and ability to stimulate interferon (INF) production [9]. Based on evidence, the gutelung axis explains the possible relationship between respiratory disorders and gut microbiome [10].…”

Section: Introductionmentioning

confidence: 99%

The efficacy of probiotics on virus titres and antibody production in virus diseases: A systematic review on recent evidence for COVID-19 treatment

Mirashrafi

Moravejolahkami

Zehi

et al. 2021

Clinical Nutrition ESPEN

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Background & Aims There are some studies indicating the effects of probiotic-containing foods or supplements on viral diseases. We aimed to conduct a rapid review of probiotics with specific emphasis on their potential for early administration in patients at greater risk of SARS-CoV-2 infection. Methods We searched on PubMed, EMBASE, Google Scholar, Science Direct, Scopus and Web of Science up to February 2021 to identify interventional and observational studies documenting the effects of probiotics strains on interleukins, virus titers, and antibody production with a focus on probiotic-containing foods (PROSPERO Registration ID. CRD42020181453). Results From a total of 163 records, 21 studies were classified into three domains based on the efficacy of probiotics on 1) the level of interleukins (n=7), 2) virus titers (n=2), and 3) interferon (IFN) and antibody production (n=12). The suppuration of pro-inflammatory interleukins and type I INF production seemed to be the main anti-viral effect of probiotics. Nine studies also indicated the beneficial effects of probiotics and fermented foods on viral diseases. Conclusion Based on evidence, some probiotic strains may be useful in viral infections; randomized trials are needed to confirm these findings.

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Effect of probiotics on oxidative stress and inflammatory status in diabetic nephropathy: A systematic review and meta-analysis of clinical trials

Cited by 45 publications

References 43 publications

A Pilot Study of the Effect of Lactobacillus casei Obtained from Long-Lived Elderly on Blood Biochemical, Oxidative, and Inflammatory Markers, and on Gut Microbiota in Young Volunteers

A Pilot Study of the Effect of Lactobacillus casei Obtained from Long-Lived Elderly on Blood Biochemical, Oxidative, and Inflammatory Markers, and on Gut Microbiota in Young Volunteers

Potential Antiviral Activity of Lactiplantibacillus plantarum KAU007 against Influenza Virus H1N1

The efficacy of probiotics on virus titres and antibody production in virus diseases: A systematic review on recent evidence for COVID-19 treatment

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