Effect of probiotics or prebiotics on thyroid function: A meta-analysis of eight randomized controlled trials

Shu, Qinxi; Kang, Chao; Li, Jiaxin; Hou, Zhenzhu; Xiong, Minfen; Wang, Xingang; Peng, Hongyan

doi:10.1371/journal.pone.0296733

Cited by 5 publications

(2 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The effect of prebiotics, probiotics and synbiotics on thyroid function was verified in the meta-analysis of eight controlled trials by the group of Qinxi et al Researchers did not indicate the intervention on TSH, fT4 and fT3 levels as statistically significant. Yet, modest reduction of TRAb levels in patients with Graves' disease was noticed [87]. However, this analysis was not dedicated to patients with chronic thyroiditis and levels of TPOAb and TgAb were not assessed.…”

Section: Gut Microbiome and Its Derivativesmentioning

confidence: 99%

Autoimmunity, New Potential Biomarkers and the Thyroid Gland—The Perspective of Hashimoto’s Thyroiditis and Its Treatment

Tywanek,

Michalak,

Świrska

et al. 2024

IJMS

View full text Add to dashboard Cite

Autoimmune thyroid disease (AITD) is the most common organic specific illness of the thyroid gland. It may manifest as the overproduction or the decline of thyroxine and triiodothyronine. Hyperthyroidism develops due to the overproduction of hormones as an answer to the presence of stimulatory antibodies against the TSH receptor. Hashimoto’s thyroiditis (HT) is generally characterized by the presence of thyroid peroxidase and thyroglobulin antibodies, with a concomitant infiltration of lymphocytes in the thyroid. Due to the progressive destruction of cells, AITD can lead to subclinical or overt hypothyroidism. Pathophysiology of AITD is extremely complicated and still not fully understood, with genetic, environmental and epigenetic factors involved in its development. Due to increasing incidence and social awareness of this pathology, there is an urgent need to expand the background concerning AITD. A growing body of evidence suggests possible ways of treatment apart from traditional approaches. Simultaneously, the role of potential new biomarkers in the diagnosis and monitoring of AITD has been highlighted recently, too. Therefore, we decided to review therapeutic trends in the course of AITD based on its pathophysiological mechanisms, mainly focusing on HT. Another aim was to summarize the state of knowledge regarding the role of new biomarkers in this condition.

show abstract

Section: Gut Microbiome and Its Derivativesmentioning

confidence: 99%

Autoimmunity, New Potential Biomarkers and the Thyroid Gland—The Perspective of Hashimoto’s Thyroiditis and Its Treatment

Tywanek,

Michalak,

Świrska

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

“…A review by our group reported how the microbiota plays a role in metabolizing endocrine disruptors introduced through diet, by means of a bidirectional interaction that leads to dysbiosis and changes in pathways involved in the development of various metabolic diseases ( 63 ). Dysbiosis and the subsequent negative influence on the immune system and intestinal permeability can promote the development of inflammatory and autoimmune diseases, including thyroid diseases ( 110 – 112 ).…”

Section: Effects Of Diet Nutrition Food Pollution and Microplastics O...mentioning

confidence: 99%

The impact of environmental factors and contaminants on thyroid function and disease from fetal to adult life: current evidence and future directions

Street,

Shulhai,

Petraroli

et al. 2024

Front. Endocrinol.

View full text Add to dashboard Cite

The thyroid gland regulates most of the physiological processes. Environmental factors, including climate change, pollution, nutritional changes, and exposure to chemicals, have been recognized to impact thyroid function and health. Thyroid disorders and cancer have increased in the last decade, the latter increasing by 1.1% annually, suggesting that environmental contaminants must play a role. This narrative review explores current knowledge on the relationships among environmental factors and thyroid gland anatomy and function, reporting recent data, mechanisms, and gaps through which environmental factors act. Global warming changes thyroid function, and living in both iodine-poor areas and volcanic regions can represent a threat to thyroid function and can favor cancers because of low iodine intake and exposure to heavy metals and radon. Areas with high nitrate and nitrite concentrations in water and soil also negatively affect thyroid function. Air pollution, particularly particulate matter in outdoor air, can worsen thyroid function and can be carcinogenic. Environmental exposure to endocrine-disrupting chemicals can alter thyroid function in many ways, as some chemicals can mimic and/or disrupt thyroid hormone synthesis, release, and action on target tissues, such as bisphenols, phthalates, perchlorate, and per- and poly-fluoroalkyl substances. When discussing diet and nutrition, there is recent evidence of microbiome-associated changes, and an elevated consumption of animal fat would be associated with an increased production of thyroid autoantibodies. There is some evidence of negative effects of microplastics. Finally, infectious diseases can significantly affect thyroid function; recently, lessons have been learned from the SARS-CoV-2 pandemic. Understanding how environmental factors and contaminants influence thyroid function is crucial for developing preventive strategies and policies to guarantee appropriate development and healthy metabolism in the new generations and for preventing thyroid disease and cancer in adults and the elderly. However, there are many gaps in understanding that warrant further research.

show abstract

Lack of genotoxicity and subchronic toxicity in safety assessment studies of Akkermansia muciniphila formulation

Yu,

Eid,

Cheng

et al. 2024

Toxicology Reports

View full text Add to dashboard Cite

Effect of probiotics or prebiotics on thyroid function: A meta-analysis of eight randomized controlled trials

Cited by 5 publications

References 38 publications

Autoimmunity, New Potential Biomarkers and the Thyroid Gland—The Perspective of Hashimoto’s Thyroiditis and Its Treatment

Autoimmunity, New Potential Biomarkers and the Thyroid Gland—The Perspective of Hashimoto’s Thyroiditis and Its Treatment

The impact of environmental factors and contaminants on thyroid function and disease from fetal to adult life: current evidence and future directions

Lack of genotoxicity and subchronic toxicity in safety assessment studies of Akkermansia muciniphila formulation

Contact Info

Product

Resources

About