Effect of probucol on hemodynamics, rheology and blood lipid of diabetic retinopathy

Liu, Hong; Cai, Mingming

doi:10.3892/etm.2018.5917

Cited by 5 publications

(3 citation statements)

References 19 publications

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“…Prior studies have confirmed that a group of CD3 T cells also express CD20 molecules in the body apart from B cells, which have similar and unique biological characteristics to conventional CD3 T cells (26). It has been demonstrated that CD3+CD20+ T cells play an important role in multiple diseases (32), such as rheumatoid arthritis (33,34), multiple sclerosis (32), psoriasis (35), lymphoproliferative disorder (36), and some cancers (31,32). In our study, we further confirmed that NP or MFS treatment decreased CD3+CD20+ T cells in TAO model rats, which could be further decreased via the synergy of NP or MFS combined with NDDM.…”

Section: Discussionmentioning

confidence: 95%

Integration of traditional Chinese medicine and nibble debridement and dressing method reduces thrombosis and inflammatory response in the treatment of thromboangiitis obliterans

Li¹,

Zhong²,

Huang³

et al. 2021

Ann Transl Med

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Background: Thromboangiitis obliterans (TAO), also known as Buerger's disease, is an occlusive arterial disease; however, the pathogenesis of TAO is still unclear. Research has shown that traditional Chinese medicine (TCM) has significant advantages in the treatment of TAO. Our purpose was to explore the underlying roles of TCM in combination with nibble debridement and dressing method (NDDM) in a TAO rat model. Methods: We administered rats with 10 mg/mL sodium laurate to establish a TAO model, and then the TAO model rats were treated with notoginseng powder (NP), maifusheng (MFS), or the combination of NP or MFS and NDDM. Gangrene classification and blood rheology were evaluated; the pathological characteristics of rat limbs were examined by hematoxylin and eosin (H&E) staining and Masson staining; and cluster of differentiation 3+ (CD3+) and cluster of differentiation 20+ (CD20+) levels were measured by immunohistochemistry (IHC) and flow cytometry. In addition, inflammation-associated cytokines were analyzed by quantitative reverse transcription polymerase chain reaction (RT-qPCR), western blot, and enzyme-linked immunosorbent assay (ELISA). Results: Integration of NP or MFS and NDDM dramatically reduced the gangrene classification and affected blood rheology parameters of TAO model rats compared with NP and MFS alone. Meanwhile, NP or MFS in combination with NDDM decreased CD3+CD20+ T cells, reduced thrombosis and inflammatory cell infiltration, and dramatically decreased the levels of inflammation-associated cytokines. Conclusions: Our results suggested that integration of NP or MFS and NDDM could relieve the symptoms of TAO model rats induced by sodium laurate, which might provide a new management strategy for TAO.

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Section: Discussionmentioning

confidence: 95%

Integration of traditional Chinese medicine and nibble debridement and dressing method reduces thrombosis and inflammatory response in the treatment of thromboangiitis obliterans

Li¹,

Zhong²,

Huang³

et al. 2021

Ann Transl Med

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“…At present, researches have shown that autoimmune mechanisms, especially abnormal erythrocyte immune function and hemorheology changes, play essential roles in the occurrence and development of TAO [29,30]. Studies have suggested that blood rheology was closely associated with a variety of diseases, such as chronic heart failure [31], sickle cell anemia [32], angina pectoris [33], diabetic retinopathy [34], etc. In our study, we proved that NP or MFS in combination with NDDM could decrease BPC, WBC, brinogen and PV levels.…”

Section: Discussionmentioning

confidence: 99%

Integration Traditional Chinese Medicine and Nibble Debridement and Dressing Method Reduce Thrombosis and Inflammatory Response in the Treatment of Thromboangiitis Obliterans

Zhong

Huang

et al. 2020

Preprint

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Background: Thromboangiitis obliterans (TAO), also known as Buerger's disease, is an occlusive arterial disease. However, the pathogenesis of TAO is still unclear. Research has shown that traditional Chinese medicine (TCM) has significant advantages in the treatment of TAO. Our purpose is to explore the underlying roles of TCM in combination with nibble debridement and dressing method (NDDM) in TAO rat model.Methods: 10 mg/ml sodium laurate was utilized to establish a TAO rat model, and then the TAO mode rats were treated with notoginseng powder (NP), maifusheng (MFS) or the combination of NP or MFS and NDDM. Ganrene’s classification and, blood rheology was evaluated; the pathological characteristics of rat limbs were examined by H&E staining and Masson staining; CD3+ and CD20+ levels were measured by immunohistochemistry and flow cytometry. In addition, inflammation-associated cytokines were analyzed by RT-qPCR, Western blot and ELISA assays. Results: ntegration NP or MFS and NDDM dramatically reduced the ganrene’s classification and affected blood rheology parameter of TAO model rats compared with NP and MFS alone. Meanwhile, NP or MFS in combination with NDDM decreased CD3+CD20+T cells, reduced thrombosis and inflammatory cell infiltration, and dramatically decreased the levels of inflammation-associated cytokines.Conclusion: Our results suggested that integration NP or MFS and NDDM could relieve the symptoms of TAO model rats induced by sodium laurate, which might provide new management strategy for TAO.

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“…Venotonic drugs such as ruscus extract and diosmine have been studied to affect leukocyte endothelial interaction and histamine-mediated increase in vascular permeability in the animal model 27 . Probucol has been shown to have positive HR effects on patients with diabetic retinopathy apart from favorable alteration in lipid profile 28 …”

Section: Discussionmentioning

confidence: 99%

Amlodipine alters hemorheological parameters: Increased efficacy at the cost of edema?

Ravindra

Arunkumar

Puniyani

et al. 2019

Indian Heart Journal

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BackgroundDespite several decades of use of calcium channel blockers, the side effect of edema persists as a class effect, and its mechanism is unresolved. Amlodipine has effects on hemorheology (HR), and its hemodilutory property may partly contribute to its antihypertensive action. This aspect is not well studied, and the literature is sparse in this regard.ObjectiveThis experiment was planned to determine effect of a single-dose administration of amlodipine on HR parameters in normal human volunteers.Methods and resultsAmlodipine (5 mg) or S (-) amlodipine (2.5 mg) was administered to 27 normal human volunteers. Whole-blood viscosity (WBV) at different shear rates, plasma viscosity (PV), red cell rigidity (RCR), red cell aggregation (RCA), hematocrit (Hct), plasma hemoglobin, along with plasma drug concentration were determined at time intervals, t = 0, 4, 8, 12, and 24 h. Statistically significant reductions were observed at tmax = 4 h in WBV at shear rates of 0.512 s–1 (p < 0.005), WBV at shear rates of 5.26 s–1 (p < 0.01), PV (p < 0.05), and Hct (p < 0.01). At t = 8 h, as drug concentration reduced, some of the changes persisted and later slowly decreased with the decreasing drug concentration till t = 24 h. Red blood cell–related parameters such as RCA and RCR remained unaltered. WBV values at all shear rates, when corrected for Hct = 0.45, did not show deviation from their original values at any time.ConclusionsAmlodipine causes a reduction in Hct and blood viscosity, along with hemodilution. These effects persist as long as the drug remains in plasma. Edema resulting from chronic dosing may be explained by the aforementioned effects. It is possible that antihypertensive action of the drug may be due to a combination of vasodilatation and an improvement in the HR properties.

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Effect of probucol on hemodynamics, rheology and blood lipid of diabetic retinopathy

Cited by 5 publications

References 19 publications

Integration of traditional Chinese medicine and nibble debridement and dressing method reduces thrombosis and inflammatory response in the treatment of thromboangiitis obliterans

Integration of traditional Chinese medicine and nibble debridement and dressing method reduces thrombosis and inflammatory response in the treatment of thromboangiitis obliterans

Integration Traditional Chinese Medicine and Nibble Debridement and Dressing Method Reduce Thrombosis and Inflammatory Response in the Treatment of Thromboangiitis Obliterans

Amlodipine alters hemorheological parameters: Increased efficacy at the cost of edema?

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