Effect of progesterone on the vaccination and immune response against Chlamydia abortus in sheep

Murcia-Belmonte, A.; Álvarez, D.; Ortega, Nieves; Navarro, J. A.; Gómez-Lucı́a, Esperanza; Buendía, A. J.; Sánchez, J.; Rı́o, Laura Del; Salinas, J.; Caro, M.R.

doi:10.1016/j.vetimm.2019.109887

Cited by 5 publications

(3 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, some authors have shown that progesterone pre-treatment facilitated chlamydial multiplication and dissemination in mice ( [28]), but another study using guinea pigs as hosts showed that, it was the oestradiol pre-treatment that produced longer infections, with greater dissemination and pathology ( [29]). In the case of C. abortus, a previous study of experimental vaccination in the natural host, progesterone was shown to have a role enhancing a protective immune response after immunisation with the same experimental vaccine used in this study ( [19]). However, in the present study we have described that, in mice, progesterone treatment exerted no positive or detrimental effect on the development of protective response induced by vaccination.…”

Section: Discussionmentioning

confidence: 58%

“…Therefore, while the role of sex hormones on the immune system is well established, the knowledge about the specific role of oestradiol and progesterone during C. abortus infection and on protection conferred by vaccination remains scarce. Interestingly, our group has recently reported that, in an experimental C. abortus vaccination of sheep, progesterone treatment induced recruitment of Treg cells into inflammatory tissue, but did not affect either the humoral response or the cell-mediated immunity induced by immunisation [19]. To deepen the understanding of these effects, in the present study we have used an ovariectomised mouse model treated with oestradiol and progesterone to study the effect of sex hormones in the pathogenesis of C. abortus infection, and also their impact on the effectiveness of vaccination.…”

Section: Introductionmentioning

confidence: 93%

See 1 more Smart Citation

Effect of Female Sex Hormones on the Immune Response against Chlamydia abortus and on Protection Conferred by an Inactivated Experimental Vaccine in a Mouse Model

et al. 2022

Self Cite

View full text Add to dashboard Cite

Mice are valuable models extensively used to test vaccine candidates against Chlamydia abortus and to clarify immunopathological mechanisms of the bacteria. As this pathogen has the ability to reactivate during pregnancy, it is important to deepen the knowledge and understanding of some of the effects of female hormones on immunity and vaccination. This study is aimed at describing the role of sex hormones in the pathology of OEA during chlamydial clearance using ovariectomised mice and also gaining an understanding of how 17β-oestradiol or progesterone may impact the effectiveness of vaccination. Animals were treated with sex hormones and infected with C. abortus, and the kinetics of infection and immune response were analysed by means of bacterial isolation, histopathology, and immunohistochemistry. In a second phase of the study, protection conferred by an experimental vaccine after hormone treatment was assessed. Oestradiol showed a stimulatory effect on the immune response during infection, with a more efficient recruitment of macrophages and T-cells at the infection site. Furthermore, after vaccination, oestradiol-treated animals showed a stronger protection against infection, indicating that this hormone has a positive effect, stimulating a specific memory response to the pathogen.

show abstract

Section: Discussionmentioning

confidence: 58%

Section: Introductionmentioning

confidence: 93%

Effect of Female Sex Hormones on the Immune Response against Chlamydia abortus and on Protection Conferred by an Inactivated Experimental Vaccine in a Mouse Model

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…Thus, experiment 1 shows the results of the INMEVA vaccine comparing them with the efficacy results obtained with an experimental inactivated vaccine widely used in different studies (i.e., the UMU vaccine). This UMU vaccine was previously tested on murine and ovine models, both with systemic ( 28 , 36 ) and local ( 39 – 41 ) challenge, showing exceptionally good protective results in all cases. In these studies, the strain used to conduct these challenges was the same strain used to develop the UMU vaccine.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Efficacy of a New Commercially Available Inactivated Vaccine Against Ovine Enzootic Abortion

Montbrau¹,

Fontseca²,

March³

et al. 2020

Front. Vet. Sci.

View full text Add to dashboard Cite

Ovine enzootic abortion (OEA), caused by Chlamydia abortus , is an economically important disease in many countries. Inactivated vaccines have been used for many years as they induce immunity in sheep, although outbreaks of abortions have been described in vaccinated flocks. In addition, there is a commercially available live attenuated vaccine that provides good protective results. Recently however, reports question the attenuation of this vaccine and associate it with the appearance of outbreaks of OEA in vaccinated flocks. In the present study, a recently commercialized inactivated vaccine (INMEVA®; Laboratorios Hipra S.A., Amer, Spain) has been evaluated using mouse and sheep experimental models. In the mouse models (non-pregnant and pregnant models), the efficacy of INMEVA vaccine has been compared to an unvaccinated control group and to an experimental inactivated vaccine considered as a positive protection control (UMU vaccine). In the non- pregnant model, the UMU vaccine was more effective than the INMEVA vaccine regarding the impact on body weight or the presence of C. abortus in the liver, but both vaccinated groups (UMU and INMEVA) had significantly lower C. abortus in the liver compared to the control group. In the pregnant model in terms of reproductive failures, pups per mouse or the presence of C. abortus in the liver or uterus, no significant differences were found between both vaccines, inducing protection compared to the control group. In the ovine pregnant model, where INMEVA vaccine was compared only to an unvaccinated group, the results indicate that this new commercial vaccine is safe and provides a suitable level of protection against an experimental challenge with C. abortus . A 75% reduction in reproductive disorders, 55% reduction in animals with C. abortus shedding on day of parturition/abortion, and a significant reduction of the average amount of chlamydial shedding from parturition/abortion over the next 21 days was observed, in relation to the infected control group. The results suggest that this vaccine is adequate for the control and prevention of OEA; however, future studies are necessary to elucidate the type of protective immune response that it induces.

show abstract

Role of route of delivery on Chlamydia abortus vaccine-induced immune responses and genital tract immunity in mice

Richardson,

Medhavi,

Tanner

et al. 2024

Microbes and Infection

View full text Add to dashboard Cite

Effect of progesterone on the vaccination and immune response against Chlamydia abortus in sheep

Cited by 5 publications

References 47 publications

Effect of Female Sex Hormones on the Immune Response against Chlamydia abortus and on Protection Conferred by an Inactivated Experimental Vaccine in a Mouse Model

Effect of Female Sex Hormones on the Immune Response against Chlamydia abortus and on Protection Conferred by an Inactivated Experimental Vaccine in a Mouse Model

Evaluation of the Efficacy of a New Commercially Available Inactivated Vaccine Against Ovine Enzootic Abortion

Role of route of delivery on Chlamydia abortus vaccine-induced immune responses and genital tract immunity in mice

Contact Info

Product

Resources

About