Effect of Prolactin on Glomerular Filtration Rate

Riley, Arthur L.; Hagen, Thad C.; Stefaniak, John

doi:10.1042/cs0550335

Cited by 8 publications

(6 citation statements)

References 8 publications

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“…Moreover, g.f.r. has been seen to increase (Lockett, 1965;MacCallum et al 1975;Riley, Hagen & Stefaniak, 1978), decrease (Bliss & Lote, 1982) or remain unchanged (Lucci et al 1975;Wallin & Lee, 1976) following acute hormone treatment.…”

Section: Discussionmentioning

confidence: 96%

Acute and chronic effects of progesterone and prolactin on renal function in the rat.

El-Karib¹,

Garland²,

Green³

1983

The Journal of Physiology

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SUMMARY1. The renal effects of acute and chronic progesterone and prolactin administration were investigated in rats.2. Acute progesterone treatment caused a reduced urinary potassium excretion compared to controls (0-80 + 0±03 vs. 1-30 + 0 04 molee min-; P < 0 01). No other renal changes were apparent.3. Acute prolactin administration produced no significant changes in renal function.4. Chronic progesterone treatment reduced urinary potassium output by increasing tubular reabsorption. Absolute reabsorption moleoe min-) for controls was 4 70 + 0-42 and for progesterone treatment, 6-40 + 0 57 (P < 0.05 comparing the two).No other renal changes were apparent. 5. Animals made pseudopregnant by chronic prolactin administration showed a significant (16 %) elevation in glomerular filtration rate, similarly enhanced fluid and solute reabsorption, and a significant (16 %) increase in proximal tubule length. This would imply a role for prolactin in early rat pregnancy and pseudopregnancy when similar renal changes are evident and circulating hormone levels high.

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Section: Discussionmentioning

confidence: 96%

Acute and chronic effects of progesterone and prolactin on renal function in the rat.

El-Karib¹,

Garland²,

Green³

1983

The Journal of Physiology

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“…Ovine prolactin has been reported to reduce renal excretion of water, sodium and potassium in man (Horrobin, Lloyd, Lipton, Burstyn, Durkin and Muiruri, 1971) and rats (Lockett & Nail, 1965). Similarly, ovine prolactin may increase the glomerular filtration rate in the dog (Riley, Hagen & Stefaniak, 1978) and affect electrolyte balance in the amniotic fluid of monkeys (Josimovich, Merisko & Boccella, 1977). However, the possibility of concomitant effects due to vasopressin contamination of these and subsequent ovine prolactin preparations cannot be entirely excluded (Waters, 1977).…”

Section: Introductionmentioning

confidence: 94%

Prolactin Receptors in the Rat Kidney

Mountjoy¹,

Cowden²,

Dobbie³

et al. 1980

Journal of Endocrinology

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Specific binding of 125I-labelled ovine prolactin iodinated by a lactoperoxidase method was demonstrated in crude membrane preparations of kidneys and adrenals of male Sprague-Dawley rats and livers from female rats. Membrane preparations derived from the 100,000 g fractions of tissue homogenates contained most of the specific prolactin binding. Kinetic and affinity characteristics of prolactin binding to kidney membranes were examined in detail. Maximal specific binding occurred after incubation for 30 h at room temperature. Scatchard analysis indicated that prolactin binding to kidney membranes was of high affinity (dissociation constant = 1.4 x 10(-10) mol/l) and similar to that for liver membranes, although kidney membranes from male rats bound approximately sixfold less prolactin/mg membrane protein than did liver membranes from female rats. Specific prolactin binding was demonstrated in both renal medulla and cortex. Autoradiography showed maximal prolactin binding activity in the epithelial cells of the proximal tubule and faint activity in the tubular cells throughout the nephron. Specificity of uptake by proximal tubular cells was indicated by the gross reduction in prolactin activity when excess ovine prolactin was administered simultaneously. The demonstration of specific binding sites for prolactin localized primarily in the proximal tubules was consistent with renal action of prolactin, predominantly on sodium metabolism.

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“…In dogs, ovine prolactin in iv doses of 6 to 13 gg per minute, i.e., delivering 15 to 33 gU of ADH per minute, did not affect urine volume and sodium excretion, but, strangely, produced an increase in GFR (Riley et al, 1976).…”

Section: Renal Prolactin Lffects In Rabbit Sheep Cat and Dogmentioning

confidence: 88%

Renale und vaskul�re Wirkung von Prolaktinpr�paraten

Vorherr

1979

Klin Wochenschr

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Prolactin, as a "broad spectrum hormone", has been described to exert also vascular and renal actions in laboratory animals and in humans. However, prolactin preparations of various species are contaminated with neurohypophysial hormones (ADH, oxytocin) which possess vascular and renal activities. Antisera against ADH, oxytocin and prolactin are rather specific inactivators of the biologic activity of the respective hormone; the oxytocinasevasopressinase system of pregnancy plasma destroys ADH and oxytocin. Incubation-identification procedures with antisera against ADH, oxytocin and prolactin and with pregnancy plasma revealed that changes in blood pressure, urine flow and urinary osmolarity cannot be ascribed to prolactin per se but to the ADH impurity of prolactin preparations. Furthermore, recent metabolic studies in normally hydrated, overhydrate and dehydrated animals and humans have shown that prolactin does not affect renal water and electrolyte excretion. Thus, earlier reports on vascular and renal activity of prolactin in laboratory animals and humans should be viewed with great caution. Elimination of neurohypophysial hormone impurities of prolactin preparations by incubation with either ADH and oxytocin antisera or with pregnancy plasma provides techniques for better assessment of the real biologic effects of the prolactin molecule.

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Effect of Prolactin on Glomerular Filtration Rate

Cited by 8 publications

References 8 publications

Acute and chronic effects of progesterone and prolactin on renal function in the rat.

Acute and chronic effects of progesterone and prolactin on renal function in the rat.

Prolactin Receptors in the Rat Kidney

Renale und vaskul�re Wirkung von Prolaktinpr�paraten

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