Effect of prolonged blood contact time on deposition of cellular and amorphous material on Teflon-coated guidewires: A scanning electron microscopy study

Moreyra, Abel E.; Khaw, Kenneth; Wilson, Alan C.; Patel, Raj

doi:10.1002/(sici)1097-0304(199608)38:4<355::aid-ccd6>3.0.co;2-6

Cited by 5 publications

(3 citation statements)

References 14 publications

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“…[3][4][5][6][7][8][9][10] While many complications are attributed to suboptimal periprocedural anticoagulation, 11 other possibilities include direct vessel injury and risk of clotting associated with contact between blood and devices such as intracoronary wires, balloons, and guide catheters. This was challenged by a study by Moreyra et al, 12 in which the deposition of cellular and amorphous material on the surface and grooves of the Teflon-coated guidewires was not significantly different at 3, 5, and 10 minutes of bloodwire contact in the presence of low-dose heparinization. The use of heparin has been associated with an optimal level of anticoagulation, most commonly tested by ACT in most patients undergoing PCI.…”

Section: Discussionmentioning

confidence: 96%

Intracoronary Macrothrombus Formation During Percutaneous Coronary Intervention Despite Optimal Activated Clotting Time Using Bivalirudin

2005

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The occurrence of intracoronary thrombus during percutaneous coronary intervention (PCI) is a well-known complication. It has been estimated that it complicates approximately 6% of all coronary procedures. Patients at highest risk for this complication include those with acute ischemic syndromes or with angiographically apparent thrombus. Since the development of PCI, intravenous unfractionated heparin (UFH) has remained the primary antithrombotic therapy for the prevention of periprocedural ischemic complications. The availability of a rapid "point of care'' test for dose individualization (the activated clotting time [ACT]) has facilitated this process. Other forms of antithrombotic therapies such as direct thrombin inhibitors or low-molecular-weight heparin have been proposed as more effective anticoagulants during PCI. Bivalirudin is a direct thrombin inhibitor proven to decrease post-PCI ischemic complication rate compared with UFH and have a lower vascular complication rate compared with glycoprotein IIb/IIIa receptor antagonists. We herein report a case of acute macrothrombus formation during PCI despite adequate ACT achieved with bivalirudin.

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Section: Discussionmentioning

confidence: 96%

Intracoronary Macrothrombus Formation During Percutaneous Coronary Intervention Despite Optimal Activated Clotting Time Using Bivalirudin

2005

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“…Although taking blood samples from coronary artery and peripheral vein seemed inconsistent, P‐selectin levels were observed to be similar in simultaneous samples drawn from coronary artery, coronary sinus and peripheral vein (27,28). Furthermore, it was reported that shear stress‐induced platelet activation might occur when a long catheter was used in drawing blood (28).…”

Section: Discussionmentioning

confidence: 99%

Effect of sedation on soluble P-selectin levels, coagulation and myocardial damage following a coronary intervention

Yazıcı

Demircan

Aygul

et al. 2006

International Journal of Clinical Practice

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This study was aimed to investigate the effect of sedation on plasma soluble P-selectin (sP-selectin) levels and initiation phase of coagulation following coronary intervention. A total of 58 patients with unstable angina were randomised into two groups of sedated (n = 29) and nonsedated (n = 29) patients. sP-Selectin, adrenaline, noradrenaline, von Willebrand factor (vWF), fibrinogen, platelet and troponin-I levels were measured before the intervention and at 30 min and 24 h after the intervention. In the sedated group, adrenaline, noradrenaline, sP-selectin and fibrinogen levels remained stable 30 min after the intervention (p > 0.05), whereas vWF level increased (p < 0.05). In the nonsedated group, 30-min sP-selectin (p < 0.001), adrenaline (p < 0.05), noradrenaline (p = 0.012), vWF (p < 0.001) and fibrinogen (p < 0.001) levels were found to be increased. Also, 24-h sP-selectin, vWF and fibrinogen levels for both groups showed significant increases when compared with the values both 30 h before (p < 0.001) and 30 min after the intervention (p < 0.001). Sedation before interventions reduces sP-selectin levels, initial phase of coagulation and, consequently, myocardial damage.

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“…We became interested in this subject because of two arguments. (a) The guide wire is a relatively large foreign surface that will trigger contact activation in situ, usually just upstream of the target lesion (1)(2)(3)(4)(5). If guide wire-induced thrombosis produces thromboembolic particles, then these may occlude a stenosis downstream and thus cause acute complications.…”

mentioning

confidence: 99%

Thrombus Formation at the Surface of Guide-Wire Models: Effects of Heparin-releasing or Heparin-exposing Surface Coatings

Aldenhoff¹,

Hanssen²,

Knetsch³

et al. 2007

Journal of Vascular and Interventional Radiology

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Effect of prolonged blood contact time on deposition of cellular and amorphous material on Teflon-coated guidewires: A scanning electron microscopy study

Cited by 5 publications

References 14 publications

Intracoronary Macrothrombus Formation During Percutaneous Coronary Intervention Despite Optimal Activated Clotting Time Using Bivalirudin

Intracoronary Macrothrombus Formation During Percutaneous Coronary Intervention Despite Optimal Activated Clotting Time Using Bivalirudin

Effect of sedation on soluble P-selectin levels, coagulation and myocardial damage following a coronary intervention

Thrombus Formation at the Surface of Guide-Wire Models: Effects of Heparin-releasing or Heparin-exposing Surface Coatings

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