Effect of prolonged experimental neck pain on exercise-induced hypoalgesia

Abstract

Nerve growth factor–induced neck pain caused widespread hypersensitivity and a reduced response to exercise over time compared with a control group that displayed an increased response to exercise.

Mechanisms and manifestations in musculoskeletal pain: from experimental to clinical pain settings

“…42 Recently, reduced exercise-induced hypoalgesia was found in healthy participants exposed to a long-term neck pain model. 44 Interestingly, exercise-induced hypoalgesia caused a reduction of the CPM effect. 6 By contrast, however, the reduction in pressure pain sensitivity due to a cold-pressor conditioning (ie, CPM) and due to exercise (ie, exercise-induced hypoalgesia) was not significantly correlated.…”

The impact of prolonged experimental neck pain on walking stability and gait kinematics - A parallel-group study

“…The present study was conducted alongside a 16-day, double-blinded study (Christensen et al, 2022). With forty healthy participants, two groups, and three test days with an alpha of 0.05 and 80% power, the study could detect an effect size of 0.24.…”

“…Experimental neck pain was induced by injection of NGF (0.5 ml, 5 μg) into the right splenius capitis between the anterior border of the upper trapezius muscle and the posterior border of the sternocleidomastoid muscle at the level of C3 (Christensen et al, 2022). Isotonic saline (0.5 ml, 0.9%) was used as a control injection.…”

“…One way of isolating the effects of pain on movement is to use experimental pain models (Christensen et al, 2022;Simonsen et al, 2019a). In recent years, intramuscular injection of nerve-growth-factor (NGF) has been used to cause muscle pain lasting for days, potentially mimicking the early phases of some painful musculoskeletal conditions (Christensen et al, 2022;Gerber et al, 2011;Schabrun et al, 2016). An intramuscular NGF injection causes muscle pain or soreness during muscle contractions for multiple days (Bergin et al, 2015;Christensen et al, 2022).…”

“…In recent years, intramuscular injection of nerve-growth-factor (NGF) has been used to cause muscle pain lasting for days, potentially mimicking the early phases of some painful musculoskeletal conditions (Christensen et al, 2022;Gerber et al, 2011;Schabrun et al, 2016). An intramuscular NGF injection causes muscle pain or soreness during muscle contractions for multiple days (Bergin et al, 2015;Christensen et al, 2022). This brief report aimed to investigate the effect of prolonged experimental neck pain on gait kinematics during walking and walking while reading on a smartphone.…”