Effect of Prolonged Use of Estrogens on Circulating Lipids in Patients with Idiopathic Hyperlipemia or Idiopathic Hypercholesteremia

Abstract

The low incidence of atherosclerosis in premnenopausal woomen

Diethylstilbestrol and Circulating Lipids in Women with Metastatic Breast Cancer: Lack of Dose Response over Three Log Units

“…The present treatment regimen provided an opportunity to study effects of increasing doses over 3 log units without appreciable differences in the metabolic parameters measured. Other studies indicated a lipid-lowering effect, with disappearance of xanthomas when estrogens were administered to hyperlipidemic subjects (20). The cholesterol effects in the present study may be related to the significantly lower pretreatment.…”

Treatment of Diabetic Retinopathy With Estrogens

“…In addition to the marked reduction in serum lipid and lipoprotein values, striking disappearance of xanthomatous lesions has been induced by means of oral estrogen therapy in patients with primary hypercholesterolemia xanthomatosis and idiopathic hyperlipemia (17, 78).…”

Oral and Intravenous Estrogens in the Treatment and Prevention of Bleeding Associated With Long‐term Anticoagulant Therapy

“…Prolonged administration of estrogens does not appear to lessen this metabolic effect, and no tolerance or resistance to the hormone has been observed (66). In addition to the marked reduction in serum lipid and lipoprotein concentrations, striking disappearance of xanthomatous lesions has been induced by oral estrogen therapy in patients with primary hypercholesterolemic xanthomatosis or idiopathic hyperlipemia (75–77). Relatively small doses of methyltestosterone can counteract completely the biochemical effects of estrogens when the two are administered simultaneously (75).…”