Effect of Prophylactic Bronchodilator Treatment with Intravenous Colforsin Daropate, a Water-soluble Forskolin Derivative, on Airway Resistance after Tracheal Intubation

Wajima, Zen’ichiro; Shiga, Toshiya; Yoshikawa, Takaki; Ogura, Akira; Imanaga, Kazuyuki; Inoue, Tetsuo; Ogawa, Ryo

doi:10.1097/00000542-200307000-00007

Cited by 5 publications

(9 citation statements)

References 26 publications

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“…Clinical trials demonstrated the low toxicity of the water-soluble forskolin in the treatment of patients with cardiac dysfunction or bronchospasm (Wajima et al, 2003;Kikura et al, 2004). Furthermore, the use of forskolin as an antileukaemogenic agent is not unprecedented, as it inhibits growth and/or induces apoptosis of different types of leukaemic cells in vitro (Laneuville et al, 1992;Moon and Lerner, 2003).…”

Section: Adverse Molecular Effects Of Bcr/abl and Pp2amentioning

confidence: 99%

ReSETting PP2A tumour suppressor activity in blast crisis and imatinib-resistant chronic myelogenous leukaemia

Perrotti

Neviani

2006

Br J Cancer

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The deregulated kinase activity of p210-BCR/ABL oncoproteins, hallmark of chronic myelogenous leukaemia (CML), induces and sustains the leukaemic phenotype, and contributes to disease progression. Imatinib mesylate, a BCR/ABL kinase inhibitor, is effective in most of chronic phase CML patients. However, a significant percentage of CML patients develop resistance to imatinib and/or still progresses to blast crisis, a disease stage that is often refractory to imatinib therapy. Furthermore, there is compelling evidence indicating that the CML leukaemia stem cell is also resistant to imatinib. Thus, there is still a need for new drugs that, if combined with imatinib, will decrease the rate of relapse, fully overcome imatinib resistance and prevent blastic transformation of CML. We recently reported that the activity of the tumour suppressor protein phosphatase 2A (PP2A) is markedly inhibited in blast crisis CML patient cells and that molecular or pharmacologic re-activation of PP2A phosphatase led to growth suppression, enhanced apoptosis, impaired clonogenic potential and decreased in vivo leukaemogenesis of imatinib-sensitive and -resistant (T315I included) CML-BC patient cells and/or BCR/ABL þ myeloid progenitor cell lines. Thus, the combination of PP2A phosphatase-activating and BCR/ABL kinase-inhibiting drugs may represent a powerful therapeutic strategy for blast crisis CML patients.

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Section: Adverse Molecular Effects Of Bcr/abl and Pp2amentioning

confidence: 99%

ReSETting PP2A tumour suppressor activity in blast crisis and imatinib-resistant chronic myelogenous leukaemia

Perrotti

Neviani

2006

Br J Cancer

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“…These three respiratory variables were measured and analysed using a CP-100 pulmonary function monitor (Bicore, Irvine, CA, USA) attached to a flow transducer (VarFlex Ò ; Bear Medical Systems, Inc., Palm Springs, CA, USA) and an oesophageal balloon catheter (SmartCath Ò , Bear Medical Systems, Inc.). [10][11][12][13] The arterial blood sample was obtained to measure plasma epinephrine and norepinephrine just before infusion of saline or carperitide (baseline) and 30 min later (just before induction of anaesthesia). The study ended before the start of the surgery.…”

Section: Methodsmentioning

confidence: 99%

“…[10][11][12] In addition, we believe any case involving anaesthesia induction with thiamylal and fentanyl and tracheal intubation to be at risk of bronchoconstriction. 13 In the present study, we used this 'model of Ó The Board of Management and Trustees of the British Journal of Anaesthesia 2006. All rights reserved.…”

mentioning

confidence: 99%

Effect of prophylactic bronchodilator treatment with i.v. carperitide on airway resistance and lung compliance after tracheal intubation

Wajima

Shiga

Imanaga

et al. 2006

British Journal of Anaesthesia

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“…Oral forskolin performed better than sodium chromoglycate in preventing asthma attacks in children and adults with mild/moderate persistent asthma, whereas inhaled forskolin was similar to beclomethasone in lung function improvement (Bauer et al, 1993; Gonz alez-S anchez et al, 2006; Huerta et al, 2010). Also when administered intravenously, forskolin had a clear bronchodilation effect and no adverse events were described (Wajima et al, 2002(Wajima et al, , 2003.…”

Section: Forskolin As An Old Natural Occurring Camp Elevating Compounmentioning

confidence: 99%

“…As reported above, forskolin (or its water-soluble derivative colforsin) has been tested in several clinical settings including cardiovascular diseases, psychiatric disorders and asthma (Bersudsky et al, 1996;Wajima et al, 2003;Kikura et al, 2004).…”

Section: Forskolin As An Old Natural Occurring Camp Elevating Compounmentioning

confidence: 99%

The Natural cAMP Elevating Compound Forskolin in Cancer Therapy: Is It Time?

Sapio

Gallo

Illiano

et al. 2016

Journal Cellular Physiology

121

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Cancer is a major public health problem and the second leading cause of mortality around the world. Although continuous advances in the science of oncology and cancer research are now leading to improved outcomes for many cancer patients, novel cancer treatment options are strongly demanded. Naturally occurring compounds from a variety of vegetables, fruits, and medicinal plants have been shown to exhibit various anticancer properties in a number of in vitro and in vivo studies and represent an attractive research area for the development of new therapeutic strategies to fight cancer. Forskolin is a diterpene produced by the roots of the Indian plant Coleus forskohlii. The natural compound forskolin has been used for centuries in traditional medicine and its safety has also been documented in conventional modern medicine. Forskolin directly activates the adenylate cyclase enzyme, that generates cAMP from ATP, thus, raising intracellular cAMP levels. Notably, cAMP signaling, through the PKA-dependent and/or -independent pathways, is very relevant to cancer and its targeting has shown a number of antitumor effects, including the induction of mesenchymal-to-epithelial transition, inhibition of cell growth and migration and enhancement of sensitivity to conventional antitumor drugs in cancer cells. Here, we describe some features of cAMP signaling that are relevant to cancer biology and address the state of the art concerning the natural cAMP elevating compound forskolin and its perspectives as an effective anticancer agent. J. Cell. Physiol. 232: 922-927, 2017. © 2016 Wiley Periodicals, Inc.

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Effect of Prophylactic Bronchodilator Treatment with Intravenous Colforsin Daropate, a Water-soluble Forskolin Derivative, on Airway Resistance after Tracheal Intubation

Abstract: Prophylactic treatment with colforsin daropate produced lower R(awm) and R(awe) and higher C(dyn) after tracheal intubation when compared with placebo medication. Pretreatment before intubation may be beneficial and advantageous for middle-aged smokers.

Cited by 5 publications

References 26 publications

ReSETting PP2A tumour suppressor activity in blast crisis and imatinib-resistant chronic myelogenous leukaemia

ReSETting PP2A tumour suppressor activity in blast crisis and imatinib-resistant chronic myelogenous leukaemia

Effect of prophylactic bronchodilator treatment with i.v. carperitide on airway resistance and lung compliance after tracheal intubation

The Natural cAMP Elevating Compound Forskolin in Cancer Therapy: Is It Time?

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