Effect of propionate on in vivo carbohydrate metabolism in streptozocin-induced diabetic rats

Cameron‐Smith, David; Collier, G.R.; O’Dea, Kerin

doi:10.1016/0026-0495(94)90122-8

Cited by 16 publications

(7 citation statements)

References 38 publications

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“…Soluble fibers increased the viscosity of the alimentary bolus, and hence lengthen the gastric emptying and intestinal transit times (Cameron-Smith, Collier, & O'Dea, 1994;Johansen, Knudsen, Sandstrom, & Skjoth, 1996;Wood, 1990). In our observation, the EPS from Agrobacterium ZX09 delayed the rate of starch digestion by pancreatic amylases in vitro, which may delay the interaction of the enzyme with its substrate (Dunaif & Schneeman, 1981;Dutta & Hlasko, 1985;Hansen & Schulz, 1982).…”

Section: Discussionmentioning

confidence: 85%

The chemical and digestive properties of a soluble glucan from Agrobacterium sp. ZX09

Xiu

Kong

Zhou

et al. 2010

Carbohydrate Polymers

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Section: Discussionmentioning

confidence: 85%

The chemical and digestive properties of a soluble glucan from Agrobacterium sp. ZX09

Xiu

Kong

Zhou

et al. 2010

Carbohydrate Polymers

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“…22 Propionate has been shown to decrease glucose production in rat hepatocytes. 25 In this experiment, the results suggested that the consumption of L. plantarum NCU116 and carrot juice led to an increase of propionic acid for preventing hyperglycemia, but a more pronounced effect was found when carrot juice was fermented with L. plantarum NCU116. The hypoglycemic effect of the FCJ observed in this study could be related to the synergistic effects of both β-carotene in carrot, gut microbiota, and the production of SCFA.…”

Section: ■ Discussionmentioning

confidence: 90%

Carrot Juice Fermented with Lactobacillus plantarum NCU116 Ameliorates Type 2 Diabetes in Rats

Ding

Nie

et al. 2014

J. Agric. Food Chem.

118

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The effect of carrot juice fermented with Lactobacillus plantarum NCU116 on high-fat and low-dose streptozotocin (STZ)-induced type 2 diabetes in rats was studied. Rats were randomly divided into five groups: non-diabetes mellitus (NDM), untreated diabetes mellitus (DM), DM plus L. plantarum NCU116 (NCU), DM plus fermented carrot juice with L. plantarum NCU116 (FCJ), and DM plus non-fermented carrot juice (NFCJ). Treatments of NCU and FCJ for 5 weeks were found to favorably regulate blood glucose, hormones, and lipid metabolism in the diabetic rats, accompanied by an increase in short-chain fatty acid (SCFA) in the colon. In addition, NCU and FCJ had restored the antioxidant capacity and morphology of the pancreas and kidney and upregulated mRNA of low-density lipoprotein (LDL) receptor, cholesterol 7α-hydroxylase (CYP7A1), glucose transporter-4 (GLUT-4), peroxisome proliferator-activated receptor-α (PPAR-α), and peroxisome proliferator-activated receptor-γ (PPAR-γ). These results have for the first time demonstrated that L. plantarum NCU116 and the fermented carrot juice had the potential ability to ameliorate type 2 diabetes in rats.

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“…(1996) opted for a repeated dosing and administered a 30‐min infusion of sodium propionate rectally in rats on a daily basis during a 19‐day period, resulting in decreased fasted glucose concentrations. On the other hand, dietary supplementation as assessed in humans (Venter, 1990; Todesco et al., 1991) and rats (Cameron‐Smith et al., 1994; Boillot et al., 1995; Berggren et al., 1996), leading to a more continuous dosing of propionate, reduced fasted glucose concentrations, with the exception of the study performed by Cameron‐Smith et al. (1994).…”

Section: Discussionmentioning

confidence: 99%

Propionate absorbed from the colon acts as gluconeogenic substrate in a strict carnivore, the domestic cat (Felis catus)

Verbrugghe

Hesta

Daminet

et al. 2011

Animal Physiology Nutrition

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In six normal-weight and six obese cats, the metabolic effect of propionate absorbed from the colon was assessed. Two colonic infusions were tested in a crossover design with intervals of 4 weeks. The test solution contained 4 mmol sodium propionate per kg ideal body weight in a 0.2% NaCl solution. Normal saline was given as control solution. Solutions were infused into the hindgut over 30 min. Blood samples were obtained prior to and at various time points after starting the infusion. As body condition did not affect evaluated parameters, all data were pooled. Plasma glucose concentrations showed differences neither over time nor during or after infusion with propionate or control. Plasma amino acid concentrations rose over time (p < 0.001), but were similar for both infusions. Plasma propionylcarnitine rose markedly towards the end of the propionate infusion and decreased afterwards (p < 0.001), whereas 3-hydroxy-3-methylglutarylcarnitine was lower 30 (p = 0.005) and 60 min (p = 0.032) after ending propionate infusions and acetylcarnitine tended to fall at the same time points (p = 0.079; p = 0.080), suggesting inhibition of gluconeogenesis from pyruvate and amino acids, but initiation of propionate-induced gluconeogenesis. In conclusion, propionate absorbed from the colon is hypothesized to act as gluconeogenic substrate, regardless of the cat's body condition.

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Effect of propionate on in vivo carbohydrate metabolism in streptozocin-induced diabetic rats

Cited by 16 publications

References 38 publications

The chemical and digestive properties of a soluble glucan from Agrobacterium sp. ZX09

The chemical and digestive properties of a soluble glucan from Agrobacterium sp. ZX09

Carrot Juice Fermented with Lactobacillus plantarum NCU116 Ameliorates Type 2 Diabetes in Rats

Propionate absorbed from the colon acts as gluconeogenic substrate in a strict carnivore, the domestic cat (Felis catus)

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