Effect of Propofol Infusion on Splanchnic Hemodynamics and Liver Oxygen Consumption in the Rat

Carmichael, F. J.; Crawford, Mark W.; Khayyam, Naiyar; Saldivia, Victor

doi:10.1097/00000542-199311000-00024

Cited by 64 publications

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“…The lack of a protective effect of propofol in an in vitro liver model might be because of the use of oxygen during its own metabolism, resulting in an oxygenation debt. In contrast, in vivo, the increase in hepatic oxygen consumption by propofol is fully compensated for by an increased oxygen supply owing to increased hepatic blood flow in rat [35] and rabbit models [36]. There is good evidence that vasodilators protect against I/R injury by improving hepatic blood flow and thus maintaining an oxygen balance and energy metabolism [37].…”

Section: Discussionmentioning

confidence: 99%

“…Since it has shown that propofol increased hepatic blood flow in a dose dependent manner [35], the hepatoprotective effect of propofol may be also dose-dependent. Lee et al, [34], found that propofol has a protective effect on hepatocytes in a clinically relevant concentrations of 1-50 M, because peak plasma concentrations of propofol are reportedly 40-60 M (7.12-10.68 g/mL) at anesthesia induction and 10-25 M (1.78-4.45 g/mL) during anesthesia maintenance [42].…”

Section: Discussionmentioning

confidence: 99%

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Propofol Protects against Ischemia/Reperfusion Injury Associated with Reduced Apoptosis in Rat Liver

Abdel-Wahab

Al-Harizy

2013

ISRN Anesthesiology

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Propofol is an intravenous anesthetic, reported to have a protective effect against ischemia/reperfusion (I/R) injury in heart and brain, but no definite data are available concerning its effect in hepatic I/R. This work investigated the effect of propofol anesthesia on hepatic I/R injury using in vivo rat model. Four groups of rats were included: sham operated, I/R (30 min ischemia and 2 h reperfusion), I/R treated with propofol (10 mg/kg/h), and I/R treated with propofol (20 mg/kg/h). Liver enzyme leakage, TNFand caspase-3 levels, and antiapoptotic Bcl-xL/apoptotic Bax gene expression, together with histopathological changes, were used to evaluate the extent of hepatic I/R injury. Compared with sham-operated group, I/R group showed significant increase in serum levels of liver enzymes (ALT, AST), TNF-, and caspase-3 and significant decrease in the Bcl-xL/Bax ratio, associated with histopathologic damage in liver. Propofol infusion significantly attenuated these changes with reduced hepatic histopathologic lesions compared with nonpreconditioned I/R group. However, no significant differences were found between two groups treated with different doses of propofol. In conclusion, propofol infusion reduced hepatic I/R injury with decreased markers of cellular apoptosis. Therefore, propofol anesthesia may provide a useful hepatic protection during liver surgery.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Propofol Protects against Ischemia/Reperfusion Injury Associated with Reduced Apoptosis in Rat Liver

Abdel-Wahab

Al-Harizy

2013

ISRN Anesthesiology

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“…The intravenous anaesthetic propofol reduces the arterial blood pressure (Grounds et al, 1985;Carmichael et al, 1993;Saarnivaara et al, 1993). Three possible underlying cardiovascular changes have been shown: a depressant eect on the myocardium (Grounds et al, 1985;Mulier et al, 1991), a decrease in systemic vascular resistance (SVR) (Boer et al, 1988;Claeys et al, 1988;Baraka et al, 1991;Boer et al, 1991;Price et al, 1992), and an increase in the venous capacitance (Robinson et al, 1994).…”

Section: Introductionmentioning

confidence: 99%

Differential effect of propofol on sympathetic neurotransmission in isolated human omental arteries and veins

Wallerstedt

Bodelsson

1998

British J Pharmacology

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The present study was undertaken to elucidate the effect of propofol on sympathetic neurotransmission in isolated human omental vessels. Segments of both arteries and veins were exposed to 0, 10−7, 10−6, 10−5 or 10−4 M propofol, and studied in vitro to determine effects on: (i) isometric tension after electrical field stimulation (EFS) or after exogenous administration of noradrenaline (NA); (ii) EFS‐stimulated release of [3H]‐NA from vessel segments preincubated with [3H]‐NA; (iii) uptake of [3H]‐NA. Propofol at 10−6 M enhanced EFS‐induced contraction in artery segments, 10−7 and 10−5 M had no effect, and 10−4 M propofol depressed EFS‐induced contraction in both artery and vein segments. Propofol did not affect the response to exogenous NA in artery and vein segments. EFS‐stimulated release of [3H]‐NA was depressed by 10−5 and 10−4 M propofol in artery segments, and by 10−4 M in vein segments. Uptake of [3H]‐NA was depressed by 10−6–10−4 M propofol in artery but not in vein segments. The results suggest that sympathetic neurotransmission is enhanced at clinical concentrations (10−6 M) of propofol in human omental arteries, but not veins. This may be due to an increased availability of NA in the neuromuscular junction resulting from a reduced presynaptic reuptake. Propofol at probably supraclinical concentrations (10−5–10−4 M) impairs the sympathetic neurotransmission in both human omental arteries and veins, probably due to an inhibitory effect on the NA release from the sympathetic nerves. British Journal of Pharmacology (1998) 125, 120–126; doi:10.1038/sj.bjp.0702021

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“…There are a limited number of animal studies on the effect of propofol on hepatic blood flow and hepatic oxygen balance, and the results of these studies are equivocal. 1,[3][4][5][6][7][8] Furthermore, the techniques used to monitor the hepatic blood flow were indirect measurements, with methodological limitations requiring interpretation of the results. 7,[9][10][11] Although there are some limitations for the electromagnetic technique, this direct measurement of hepatic blood flow is considered to be an accurate method of measuring blood flow within vessels.…”

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confidence: 99%

Effect of propofol on hepatic blood flow and oxygen balance in rabbits

Zhu

Pang

McCluskey

et al. 2008

Can J Anesth/J Can Anesth

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reports of original investigations CAN J ANESTH 55: 6 www.cja-jca.org June, 2008 Purpose: Propofol has been reported to alter hepatic blood flow and to increase hepatic oxygen consumption. This study was designed to determine the effect of propofol on hepatic blood flow and oxygenation in rabbits, in order to establish its net effect on hepatic oxygen balance.Methods: Twenty, adult male, New Zealand white rabbits were randomly divided into two groups: Group P (propofol, 0.6 mg·kg). An electromagnetic flowmeter was used to measure hepatic blood flow, and blood, from the carotid artery, the portal vein, and the hepatic vein, was used to determine hepatic oxygenation. After we obtained baseline values, we repeated measurements ten, 30, and 60 min after initiating the infusion.Results: Intralipid did not affect systemic hemodynamics, hepatic blood flow, or oxygenation during the 60 min infusion; however, propofol caused a time-dependent decrease in mean arterial blood pressures and an increase in portal venous flow and total hepatic blood flow. In contrast, hepatic arterial blood flow remained unchanged during the propofol infusion. Hepatic oxygen delivery and consumption increased in a time-dependent manner to maximums of 25% and 21.4% (both, P < 0.05) above baseline, respectively. Hepatic venous oxygen saturation and extraction was unchanged throughout the study period. Conclusion:Propofol increases total hepatic blood flow, primarily by increasing hepatic portal venous flow. The increase in liver oxygen consumption was fully compensated by an increase in oxygen supply to the liver, resulting in a preserved, hepatic oxygen balance.

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Effect of Propofol Infusion on Splanchnic Hemodynamics and Liver Oxygen Consumption in the Rat

Cited by 64 publications

References 0 publications

Propofol Protects against Ischemia/Reperfusion Injury Associated with Reduced Apoptosis in Rat Liver

Propofol Protects against Ischemia/Reperfusion Injury Associated with Reduced Apoptosis in Rat Liver

Differential effect of propofol on sympathetic neurotransmission in isolated human omental arteries and veins

Effect of propofol on hepatic blood flow and oxygen balance in rabbits

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