Effect of propylene glycol on fatty liver development and hepatic fructose 1,6 bisphosphatase activity in periparturient dairy cows

Rukkwamsuk, Theera; Rungruang, Soonthorn; Choothesa, Apassara; Wensing, Theo

doi:10.1016/j.livprodsci.2004.12.006

Cited by 24 publications

(27 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The mechanism by which the energy from PG supplementation contributed to the BW deposit rather than milk production is not clear. Nevertheless, fail to increase milk production with increasing PG supplementation is in agreement with previous studies (Formigoni et al, 1996;Miyoshi et al, 2001;Pickett et al, 2003;Rukkwamsuk et al, 2005). In contrast, Miettinen (1995) reported higher milk yield on the second test day in the treated group than in the control group.…”

Section: Discussionsupporting

confidence: 91%

“…Thus, energy intake would be similar if the PG portion was removed from the calculation. Lack of the effect of PG supplementation on DM intake in this study is consistent with some results (Pickett et al, 2003;Rukkwamsuk et al, 2005;Moallem et al, 2007), but contrasts to other report (Miyoshi et al, 2001). The last researchers reported decreased feed intake after 2 days of top-dressing 518 g PG per day and suggested that the decrease of DM intake was due to the low palatability of PG.…”

Section: Discussionsupporting

confidence: 88%

See 1 more Smart Citation

Effects of feeding propylene glycol on dry matter intake, lactation performance, energy balance and blood metabolites in early lactation dairy cows

Liu

Wang

Yang

et al. 2009

Animal

View full text Add to dashboard Cite

The objectives of this study were to evaluate effects of feeding propylene glycol (PG) on feed intake, milk yield and milk composition, blood metabolites and energy balance in Holstein dairy cows from 1 to 63 days in milk. Thirty-two multiparous cows, blocked by lactation number, previous 305-day milk production and expected calving date, were arranged into four groups in a randomized block design. Treatments were: control, low PG, medium PG and high PG with 0, 150, 300 and 450 ml PG per cow per day, respectively. The supplement of food grade PG (0.998 g/g PG) was hand-mixed into the top one-third of the daily ration. Cows were fed ad libitum a total mixed ration consisting of forage and concentrate (50 : 50, dry matter basis). Feed intake, milk yield and milk components were not affected ( P . 0.05) by PG supplementation. Overall, body weight (BW) loss tended ( P , 0.08) to be linearly reduced, and energy status was linearly improved with increasing PG supplementation. Concentrations of glucose in plasma were higher for cows fed PG relative to control (55.6 v. 58.9 mg/dl) and linearly increased ( P , 0.01) with increasing PG supplementation. Plasma concentrations of non-esterified fatty acids and beta-hydroxybutyrate were linearly increased, but urine acetoacetate concentration was quadratically changed with the highest for control diet and the lowest for 450 ml/day of PG. These results indicated that supplementation of PG in the early lactating cow diets had minimal effects on feed intake and milk production, but may potentially reduce contents of milk fat and milk protein. Supplementation of early lactating dairy cow diets with PG is beneficial in terms of improving energy status and reducing BW loss.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 88%

Effects of feeding propylene glycol on dry matter intake, lactation performance, energy balance and blood metabolites in early lactation dairy cows

Liu

Wang

Yang

et al. 2009

Animal

View full text Add to dashboard Cite

show abstract

“…Energy deficiency and/or decreased feed intake during the periparturient period result in increased lipolysis of deposited fat and release of NEFA to the blood (Hayirli et al 2003, Grummer 2008). An excessive increase of NEFA concentration leads to an accumulation of triglycerides (TG) in liver and significant increase of ketonic compounds production (Rukkwamsuk et al 2005). Studies on short-term feeding of cows with propylene glycol did not reveal any influence of PG on body mass, BCS condition or milk yield (Studer et al 1993, Pickett et al 2003.…”

Section: Discussionmentioning

confidence: 99%

“…Propylene glycol (PG) is a glucogenic precursor which has been used in prevention and treatment of ketosis in cows for many years. The mechanism of its action is based on lowering the non-esterified fatty acid (NEFA) and betahydroxybutyrate acid (BHBA) levels in blood as well as on increase of insulin and glucose levels (Studer et al 1993, Grummer et al 1994, Christensen et al 1997, Rukkwamsuk et al 2005. Kristensen & Raun (2007) demonstrated, that supplementation with propylene glycol results in an increased L-lactate and propionate supply for gluconeogenesis.…”

Section: Introductionmentioning

confidence: 99%

Influence of propylene glycol and glycerin in Simmental cows in periparturient period on milk yield and metabolic changes

et al. 2011

View full text Add to dashboard Cite

Abstract. The aim of this study was to compare the influence of propylene glycol and glycerin added to Total Mixed Ration (TMR) dose on lipid-carbohydrate metabolism, activity of selected liver enzymes and milk yield of Simmental cows in periparturient period. Forty two cows of Simmental breed were divided into 3 groups (n=14). Cows from the experimental groups were given 300 ml/d of either propylene glycol or glycerin from 7th day prepartum to 21st day postpartum. In week 5 of lactation in cows that were given propylene glycol and in week 12 in cows receiving glycerin Body Condition Score (BCS) was higher as compared to control cows. An application of glycerin resulted in the highest milk yield. Higher glucose content in groups that were given propylene glycol and glycerin would have contributed to the reduction of negative energy balance at the beginning of lactation. The lowest increase in aspartate transaminase (AST) and bilirubin level was observed in cows receiving glycerin. The study demonstrated that metabolic changes in Simmental breed cows in the periparturient period are dramatic, and an application of glucogenic precursors may improve metabolic efficiency.

show abstract

“…Los resultados obtenidos en esta investigación no coinciden con los obtenidos por Rukkwamsuk et al (2005), ya que la metodología de la toma de muestra y el tiempo de medición no fueron similares.…”

Section: Discussionunclassified

Efecto del nivel de suplementación con propilenglicol durante el período de transición a la lactancia sobre actividad ovárica y desempeño reproductivo en vacas Holstein

Ruiz

Góez

Herrera

et al. 2017

Rev. Lasallista Investig.

View full text Add to dashboard Cite

31Efecto del nivel de suplementación con propilenglicol durante el período de transición a la lactancia sobre actividad ovárica y desempeño reproductivo en vacas HolsteinEffect of supplementation level with propylene glycol during the transition period to lactation on ovarian activity and reproductive performance in Holstein cows AbstractIntroduction. This paper mainly focuses on the study of the inclusion of propylene glycol (PG) as energy compound and its possible effect on minimizing the negative energy balance. Objetive. Evaluate on reproductive parameters, specifically on rates of calving to first service, days open, calving to first observed heat, as well as its effect on insulin secretion and ovarian activity. Materials and Methods. 20 Holstein cows were assigned to one of four supplementation levels: 0, 300, 500 and 700 grams of PG / day mixed in food, from day 10 prepartum and through day 20 postpartum. Blood samples were collected on 10 and 5 prepartum and days 0, 5, 10 15 and 20 postpartum to determine the concentration of insulin were also done to determine transrectal ultrasound follicular growth and ovarian resumption. All data for the evaluation of reproductive parameters were taken from the day of delivery, making daily observations of animals 30 minutes in the morning and 30 minutes in the afternoon to record possible heat presented. Results. There were no significant differences for the variables within the different treatments (p> 0.05), only a trend to decrease the open days when you include a dose of 500 g of propylene glycol with respect to the other groups.Conclusions. The inclusion of propylene glycol had no significant effect on insulin secretion, or the number and size of preovulatory follicles (p> 0.05). It is very likely that the propylene supply mode and time of collection of blood samples affect the identification of the increase in insulin secretion.

show abstract

Effect of propylene glycol on fatty liver development and hepatic fructose 1,6 bisphosphatase activity in periparturient dairy cows

Cited by 24 publications

References 16 publications

Effects of feeding propylene glycol on dry matter intake, lactation performance, energy balance and blood metabolites in early lactation dairy cows

Effects of feeding propylene glycol on dry matter intake, lactation performance, energy balance and blood metabolites in early lactation dairy cows

Influence of propylene glycol and glycerin in Simmental cows in periparturient period on milk yield and metabolic changes

Efecto del nivel de suplementación con propilenglicol durante el período de transición a la lactancia sobre actividad ovárica y desempeño reproductivo en vacas Holstein

Contact Info

Product

Resources

About