Effect of prostaglandin F2? on function of the tissue component of the albino rat blood clotting and fibrinolysis system when protein metabolism is disturbed

Glants, R. M.; Mudrovskaya, L. V.

doi:10.1007/bf00831217

Bull Exp Biol Med

1983

DOI: 10.1007/bf00831217

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Effect of prostaglandin F2? on function of the tissue component of the albino rat blood clotting and fibrinolysis system when protein metabolism is disturbed

R. M. Glants¹,

L. V. Mudrovskaya²

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Comparative Study of Activities between Verbascoside and Rutin by Docking Method

et al. 2003

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Verbascoside and rutin possess anti-cancer properties and are capable of repairing DNA damaged by oxygen radicals, acting as powerful antioxidants. Based on kinetic measurements and experiments on tumor cells, docking studies of the two ligand molecules with the receptor telomeric DNA fragments have been carried out. The docking calculations performed using JUMNA software showed that the both molecules can be docked into the minor groove of telomeric DNA and form complexes with suitable geometry for electron transfer between guanine radical and ligands. The reaction mechanism via the electron transfer process is further confirmed through energy calculations for transition states using MOPAC 93 program. Complexes can be formed without major distortion of DNA structure and are further stabilized by the interaction of DNA with the saccharide side-groups. By comparing their energies, the difference of activities of the two compounds can be explained.

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Comparative Study of Activities between Verbascoside and Rutin by Docking Method

et al. 2003

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Effects of hypercholesterolemia on the nucleotide content in human blood cells

Zöllner

1992

Eur J Clin Investigation

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In hypercholesterolemia significant changes in the nucleotide pattern of erythrocytes and lymphocytes as determined by high performance liquid chromatography were found. The decrease in ATP of lymphocytes in hypercholesterolemia from 10.4 +/- 0.3 to 7.0 +/- 0.4 nmol mg-1 protein (n = 8) was associated with an increase in ADP from 2.2 +/- 0.2 to 4.0 +/- 0.2 nmol mg-1 protein (P less than 0.005). The pattern of guanosine phosphates likewise was found to be changed in hypercholesterolemia. Akin to lymphocytes, red blood cells displayed marked changes in nucleotide levels. No such changes were observed in platelets. Cultured lymphocytes incubated with human plasma low density lipoproteins (LDL) (140 mg cholesterol dl-1) displayed a reversible fall in ATP and an increase in ADP by about 40% and 160%, respectively, with high density lipoproteins (HDL) or very low density lipoproteins (VLDL) being essentially ineffectual. It is concluded that in hypercholesterolemia a significant change in the nucleotide pattern of blood cells is exerted by the increase in LDL. Possible pathophysiological implications are discussed.

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Effect of prostaglandin F2? on function of the tissue component of the albino rat blood clotting and fibrinolysis system when protein metabolism is disturbed

Cited by 2 publications

References 0 publications

Comparative Study of Activities between Verbascoside and Rutin by Docking Method

Comparative Study of Activities between Verbascoside and Rutin by Docking Method

Effects of hypercholesterolemia on the nucleotide content in human blood cells

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