Effect of prostaglandins on mucosal blood flow and aspirin-induced damage in the canine stomach.

Abstract

Abstract-This study deals with the action in anesthetized dogs of prostaglandin E2 and F20 given into the celiac artery and the femoral vein on gastric mucosal blood flow and on gastric mucosal damage induced by aspirin. In the non-stimulated stomach , infusion of prostaglandin E2 or F2 into the celiac artery resulted in a marked increase in mucosal blood flow and a sustained decrease, respectively. In contrast, an infusion of pro staglandin E2 into the femoral vein produced a decrease in mucosal blood flow , whereas prostaglandin F21 produced a biphasic response: a transient increase followed by a decrease. It was observed that intravenously infused prostaglandin E2, while reducing mucosal blood flow, significantly diminished mucosal lesions, altered transmucosal potential differences and H+ back-diffusion induced by a topical application of aspirin. The findings indicate that the action of prostaglandins on gastric mucosal blood flow alters depending on the route of administration and that prostaglandins seem to exert gastric cytoprotection through mechanisms other than an increase in mucosal blood flow.

Protective Effects of Arbaprostil against Indomethacin-Induced Gastric Lesions in Rats: Significance of Maintained Gastric Blood Flow.

“…Even though the lack of increase in resting GBF may be a secondary response related to the fall of SBP, the result coincides with previous observations (22,23) that PGE2 and 16,16-dimethyl PGE2 did not increase resting GBF.…”

Effects of prostaglandin E1, E2 and 16,16‐dimethyl‐E2 on gastric mucosal microcirculation and basal acid output in the rat*

“…This technique has been shown to provide unreliable values during changes in acid output (Holm-Rutili & Berglindh 1986) or when acid output is low (Archibald et al 1975). Other investigators (Inatomi & Maki 1983), however, have suggested that the inconsistent results reported earlier were not due to the differences in the method of measurement but to the differences in the route of administration.…”

“…Earlier reports on the influence of exogenous PGEs on GMBF are conflicting (Jacobson 1970, Main & Whittle 1973, Cheung & Lowrey 1978a, Cheung et al 1978b, Robert 1981, Gerber & Nies 1982, Inatomi & Maki 1983. It has been suggested (Gerber & Nies 1982) that discrepancies in the reported effects of PGEs on GMBF arose from the use of the AP clearance technique.…”

“…T h e conclusions from previous studies of the effect of E type prostaglandins on gastric mucosat blood flow (GMBF) have not been consistent. Thus, increases have been reported in both acid stimulated and unstimulated animals (Main & Whittle 1973, Cheung & Lowrey 1978a, Robert 1981, Gerber & Nies 1982, Inatomi & Maki 1983, while others have reported a decrease in the mucosal blood flow (Jacobson 1970, Main & W-hittle 1973, Cheung et al 1978b, Robert 1981, Inatomi & Maki 1983. T h e different conclusions may depend on several factors like, for example, the method employed for blood flow measurements, the species and anaesthetic used, the acid secretory state, the doses given and the route of administration.…”