Effect of protein adsorption on the dissolution kinetics of silica nanoparticles

Ali, Muhammad; Uttinger, Maximilian J.; Romeis, Stefan; Schmidt, Jochen

doi:10.1016/j.colsurfb.2022.112466

Cited by 12 publications

(8 citation statements)

References 81 publications

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“…These results are in accordance with what was described by Ali et al (2022) who reported surface areas in the same range for commercial Stöber nanoparticles. 46 On the other hand, it is important to highlight the importance of the surface area since, as Zych et al described, nanoparticles of similar size can present quite different specific surface areas. In these cases, the high specific surface area is related to the presence of a relatively high number of micropores (pores with sizes less than 2 nm).…”

Section: Resultsmentioning

confidence: 99%

Adsorption of immunomodulatory proteins over silica nanoparticles and the in vitro effect

Giorgi,

Genovés,

Díaz

et al. 2024

Mater. Adv.

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Section: Resultsmentioning

confidence: 99%

Adsorption of immunomodulatory proteins over silica nanoparticles and the in vitro effect

Giorgi,

Genovés,

Díaz

et al. 2024

Mater. Adv.

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“…Martinolich et al 44 have shown the Cumetalloproteins driven oxidative dissolution of silver nanoparticles. Recently, Ali et al 45 showed the protein driven dissolution of silica nanoparticles via charge transfer between a positively charged amino acid in the protein with the negatively charged surface of silica nanoparticles. We hypothesize that the protein driven dissolution mechanism could be the primary reason for multiple metal ions release considering the binding affinity of FeNiCu ternary metal nanoparticles with a bacterial cell membrane or cytoplasmic protein functional groups.…”

Section: Resultsmentioning

confidence: 99%

In Situ Microscopic Studies on the Interaction of Multi-Principal Element Nanoparticles and Bacteria

et al. 2023

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Multi-principal element nanoparticles are an emerging class of materials with potential applications in medicine and biology. However, it is not known how such nanoparticles interact with bacteria at nanoscale. In the present work, we evaluated the interaction of multi-principal elemental alloy (FeNiCu) nanoparticles with Escherichia coli (E. coli) bacteria using the in situ graphene liquid cell (GLC) scanning transmission electron microscopy (STEM) approach. The imaging revealed the details of bacteria wall damage in the vicinity of nanoparticles. The chemical mappings of S, P, O, N, C, and Cl elements confirmed the cytoplasmic leakage of the bacteria. Our results show that there is selective release of metal ions from the nanoparticles. The release of copper ions was much higher than that for nickel while the iron release was the lowest. In addition, the binding affinity of bacterial cell membrane protein functional groups with Cu, Ni, and Fe cations is found to be the driving force behind the selective metal cations’ release from the multi-principal element nanoparticles. The protein functional groups driven dissolution of multielement nanoparticles was evaluated using the density functional theory (DFT) computational method, which confirmed that the energy required to remove Cu atoms from the nanoparticle surface was the least in comparison with those for Ni and Fe atoms. The DFT results support the experimental data, indicating that the energy to dissolve metal atoms exposed to oxidation and/or the to presence of oxygen atoms at the surface of the nanoparticle catalyzes metal removal from the multielement nanoparticle. The study shows the potential of compositional design of multi-principal element nanoparticles for the controlled release of metal ions to develop antibacterial strategies. In addition, GLC-STEM is a promising approach for understanding the nanoscale interaction of metallic nanoparticles with biological structures.

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“…The interaction between collagen and PDMS-modified silica composites has significant implications for drug delivery, particularly affecting the dissolution kinetics of drugs. The adsorption of proteins such as collagen onto drug carriers can markedly modify the release profiles and bioavailability of therapeutics [ 28 , 29 ]. With PDMS-modified silica composites, the ability to adsorb collagen and potentially other proteins provides a method to modulate the drug release environment.…”

Section: Discussionmentioning

confidence: 99%

Optimization of Polydimethylsiloxane-Modified Composite Synthesis and Its Impact on Collagen Interactions: Perspectives for Biomedical Applications

Kadziński,

Banecki

2024

Materials

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This research explores how silica composites modified with polydimethylsiloxane interact with collagen, aiming to enhance their application in the biomedical field. By adjusting the amount of polydimethylsiloxane in these composites, we evaluated their capacity to bind with collagen, an essential feature for biomaterials used in tissue engineering and drug delivery. Our findings reveal that incorporating polydimethylsiloxane into silica composites significantly boosts collagen attachment, indicating strong binding interactions. Notably, the collagen adhered to the composites maintains its natural structure, ensuring its functionality and compatibility with living tissues. This aspect is critical for biomaterials that support cell growth and regeneration in tissue scaffolds. Additionally, this study investigates how the viscosity of polydimethylsiloxane influences collagen binding, offering insights into the tailoring of composite properties for better biological performance. This work highlights the potential of polydimethylsiloxane-modified silica composites in creating innovative biomaterials for regenerative medicine and targeted therapeutic delivery.

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Effect of protein adsorption on the dissolution kinetics of silica nanoparticles

Cited by 12 publications

References 81 publications

Adsorption of immunomodulatory proteins over silica nanoparticles and the in vitro effect

Adsorption of immunomodulatory proteins over silica nanoparticles and the in vitro effect

In Situ Microscopic Studies on the Interaction of Multi-Principal Element Nanoparticles and Bacteria

Optimization of Polydimethylsiloxane-Modified Composite Synthesis and Its Impact on Collagen Interactions: Perspectives for Biomedical Applications

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