Effect of Protein C Gene Mutation on Coagulation and Inflammation in Hemorrhagic Shock

Burruss, Sigrid; Andakyan, Arthur; Romanov, Sergei; Semiletova, Natalya V.; Cryer, Henry

doi:10.1016/j.jss.2011.06.055

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2015

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“…Rodent models are inexpensive and transgenic techniques such as protein C gene mutations provide opportunities to manipulate and evaluate isolated pathways within the coagulation system (212). Rodents have also consistently demonstrated the ability to achieve the clinical definition of ATC in response to trauma and hemorrhage (29, 40, 65).…”

Section: Discussionmentioning

confidence: 99%

Validation of acute traumatic coagulopathy in an ovine model of trauma and haemorrhage

Zyl¹

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This thesis describes an ovine model of complex trauma and haemorrhage that demonstrates coagulation changes using both traditional plasma based assays and point of care viscoelastic assays that are consistent with current definitions of ATC. The degree of coagulopathy was correlated with the degree of shock as quantified by arterial lactate.Coagulopathy was also associated with activation of the protein C pathway and shedding of the endothelial glycocalyx. Fibrinolysis did not make a significant contribution to the coagulopathy observed and there was no evidence of altered platelet function in this model.ii

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Section: Discussionmentioning

confidence: 99%