Effect of protein deficiency on the inducibility of the hepatic microsomal drug-metabolizing enzyme system—II

Mgbodile, Marcel U.K.; Hayes, Jeffrey A.; Campbell, T. C.

doi:10.1016/0006-2952(73)90228-1

Cited by 44 publications

(8 citation statements)

References 13 publications

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“…23 Protein deficiency in rats and man have been shown to alter the pharmacokinetics and disposition of drugs such as phenylbutazone," a n t i p~r i n e ,~' and the~phylline,*>~~ which are metabolized by the microsom-a1 mixed-function oxidases in the liver. As a result of conflicting data, no concrete conclusions can be made regarding the influence of dietary protein on the disposition of oxidatively metabolized drugs.…”

Section: Resultsmentioning

confidence: 99%

Pharmacokinetics of theophylline in protein‐calorie malnutrition

Jung¹

1985

Biopharm & Drug Disp

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The influence of protein-calorie malnutrition (PCM) on the disposition of theophylline was investigated in male Sprague-Dawley rats fed for four weeks on a 23 per cent (control) or 5 per cent (low) protein diet ad lib. Dietary protein deficiency led to a decrease in body weight gain, plasma proteins, albumin, microsomal proteins, and cytochrome P-450. After intravenous administration of aminophylline equivalent to 10 mg kg-1 theophylline, the average mean residence time (MRT) was 58 per cent higher in the protein-deficient rats, while the total plasma clearance (Cl) per kilogram of body weight and elimination rate constant (k) were decreased by 39 per cent and 45 per cent, respectively, when compared to rats on a normal protein diet. No significant difference was found in the two groups of animals with respect to the apparent steady-state volume of distribution (Vss). The present results suggest that the mechanism responsible for the observed pharmacokinetic changes in the protein-deficient rats is related to the reduced amount and/or activity of the hepatic mixed function oxidases.

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Section: Resultsmentioning

confidence: 99%

Pharmacokinetics of theophylline in protein‐calorie malnutrition

Jung¹

1985

Biopharm & Drug Disp

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“…However, when the fish were exposed to PCB but fed a low energy diet, the growth performance was not affected (Table 2, group B vs group A). Several factors, including environmental temperature (Dewaide 1970;Stegeman 1979;Koivusaari 1983), species, sex and age (Kato 1974;Klenow et al 1987;Stegeman et al 1987) or dietary factors such as protein (Campell 1977 1978; Mgbodile et al 1973; Dickerson et al 1976), lipid (Norred and Wade 1972;Lang et al 1978;Hammer and Wills 1979;Christon et al 1988), may affect the cytochrome system. In our study, these factors were kept as identical as possible in all the experimental groups and only the dietary energy level was varied.…”

Section: Discussionmentioning

confidence: 99%

The influence of dietary energy levels with and without PCB induction on the growth of tilapia, Oreochromis niloticos x O. aureus

Shiau

Chen

1992

Fish Physiol Biochem

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The effects of three dietary energy levels, 323, 365 and 408 Kcal/100g diet, on the growth performance of hybrid tilapia, Oreochromis niloticus x O. aureus, were studied. The experiment was carried out for 3 months in a recirculating rearing system. Growth and feed conversion ratios were significantly reduced (p<0.05) in fish exposed to 100 ppm polychlorinated biphenyl (PCB), fed high energy diets (365 and 408 Kcal/100g diet). The hepatic cytochrome P-450 and NADPH-cytochrome c reductase activities were also significantly (p<0.05) lower in PCB-treated fish fed high energy diets (365 and 408 Kcal/100g diet) than fish fed lower energy diet (323 Kcal/100g diet). The malic enzyme activity and the body lipid content in fish generally increased as the dietary energy level increased.

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“…However, as shown in Table 3, the increase is at best modest and the minor variation is unlikely to be of any important physiological significance. Concerning the effect of protein quantity on the activity of liver microsomal MFO system, it has been shown so far that diets with lower levels of casein (5-12% by weight) decrease the activities of liver microsomal MFO system as measured by cytochrome P-450, O-deethylase, O-demethylase, N-demethylase and hydroxylase compared with a diet containing a normal level of casein (20% by weight) (2,4,8,9,11,(13)(14)(15). This discrepancy between these and our results appears to depend on protein quality, where casein has limiting amino acids and whole egg protein no limiting amino acids.…”

Section: Discussionmentioning

confidence: 99%

“…SAITO et al normal levels (2,4,(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16). By contrast, dietary protein excess is reported to increase (11) or decrease (13) the activity of liver microsomal MFO system.…”

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confidence: 99%

Liver Microsomal Mixed-Function Oxidases in Response to Dietary Whole Egg Protein Levels in Rats.

Saito

Oh-hashi

Yamaguchi

1992

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryRelation between the activity of liver microsomal mixed function oxidase system and dietary protein level was investigated in rats using purified whole egg protein, i.e. free from limiting amino acids . The animals were given either a diet containing 0, 5, 10, 20 or 40% of protein (experiment 1) or a diet containing 5, 10, 15 or 20% of protein (exper iment 2) for 16 days. In experiment 2, half of the rats of each group were intraperitoneally injected sodium phenobarbital (PB) to induce the mix ed-function oxidase system. The cytochrome P-450 content plateaued even at 5% level of dietary protein in experiment 1 and in the PB -untreated groups of experiment 2. However, it showed the highest value at 15% protein level in the PB-treated groups of experiment 2, indicating a shift of the response peak to a higher protein level due to an increase in protein requirement. Cytochrome P-450 reflected most specifically the dietary protein levels when the enzyme system was induced by PB . The 15% protein level, equivalent to 14.1 protein calories % , is a little higher than the optimal dietary level of whole egg protein ever obtained by usual nutritional indices.

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Effect of protein deficiency on the inducibility of the hepatic microsomal drug-metabolizing enzyme system—II

Cited by 44 publications

References 13 publications

Pharmacokinetics of theophylline in protein‐calorie malnutrition

Pharmacokinetics of theophylline in protein‐calorie malnutrition

The influence of dietary energy levels with and without PCB induction on the growth of tilapia, Oreochromis niloticos x O. aureus

Liver Microsomal Mixed-Function Oxidases in Response to Dietary Whole Egg Protein Levels in Rats.

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