Effect of Protein Intake Early in Life on Kidney Volume and Blood Pressure at 11 Years of Age

Parada, Esther; Ferré, Natàlia; Luque, Verónica; Gruszfeld, Dariusz; Gradowska, Kinga; Closa‐Monasterolo, Ricardo; Koletzko, Berthold; Grote, Veit; Escribano, Joaquín

doi:10.3390/nu15040874

Cited by 2 publications

(4 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, because a higher maximum creatinine between day 3 and day 7 after birth was a risk factor for systolic HBP in our cohort, the role of kidneys is likely, as suggested by this study performed in general population where early high protein intake was associated with later systolic hypertension and an increase in kidney volume at 11 years of age. 4 The mechanism underlying this relationship could be the role of senescence pathways as observed in rats. 36 …”

Section: Discussionmentioning

confidence: 99%

“…This association could be mediated by altered kidney function. 4 Literature suggests postnatal nutritional intakes could be determinants of later HBP at 6.5 years of age in infants born very preterm as well. 5 Concerns have been raised that not only low intakes but also high intakes in infancy might contribute to higher blood pressure (BP) and increased cardiovascular risk later in life in this high‐risk population.…”

mentioning

confidence: 99%

See 1 more Smart Citation

High Amino Acid Intake in Early Life Is Associated With Systolic but Not Diastolic Arterial Hypertension at 5 Years of Age in Children Born Very Preterm

Rozé,

Bacchetta,

Lapillonne

et al. 2024

JAHA

View full text Add to dashboard Cite

Background The life course of individuals born very premature is a topic of increasing concern. The association between high early amino acid intake and later high blood pressure (HBP) in preterm neonates is debated. Methods and Results In a national, prospective, population‐based birth cohort, EPIPAGE‐2 (Etude Epidémiologique sur Petits Ages Gestationnels), we assessed blood pressure at 5 years. Eligible infants were those born between 24 and 29 weeks of gestation. Infants were distributed in 2 groups of 717 infants matched on propensity score on whether or not they were exposed to high amino acid intake (>3.5 g/kg per day at day 7); 455 control term infants were also enrolled. A value ≥95th percentile of reference values for age and height defined systolic or diastolic HBP. Blood pressure at 5 years of age was assessed for 389 and 385 children in the exposed and nonexposed groups, respectively. Rates (in percent) of systolic and diastolic HBP were 18.0% (95% CI, 14.5%–22.2% ) , 13.3% (95% CI, 10.3%–17.0%), 8.5% (95% CI, 6.5%–11.1%), and 9.0% (95% CI, 6.6%–12.3%), 10.2% (95% CI, 7.5%–13.6%), and 5.4% (95% CI, 3.8%–7.6%) in exposed, nonexposed, and term‐born groups, respectively. Exposure to high early amino acid intake and maximal serum creatinine (by 50 μmol/L) between day 3 and day 7 were 2 independent risk factors for systolic HBP (adjusted odds ratio [aOR], 1.60 [95% CI, 1.05–2.43] and aOR, 1.59 [95% CI, 1.12–2.26], respectively) but not for diastolic HBP (aOR, 0.84 [95% CI, 0.50–1.39] and aOR, 1.09 [95% CI, 0.71–1.67], respectively). After adjustment for 5‐year weight Z score, the aOR between high early amino acid intake and systolic HBP was 1.50 [95% CI, 0.98–2.30]. Conclusions These results suggest that mechanisms of childhood systolic HBP involve neonatal renal challenge by high amino acid intake or dysfunction.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

High Amino Acid Intake in Early Life Is Associated With Systolic but Not Diastolic Arterial Hypertension at 5 Years of Age in Children Born Very Preterm

Rozé,

Bacchetta,

Lapillonne

et al. 2024

JAHA

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

“…The mean (SD) systolic BP was higher in the exposed group: 101. 4 S5A), but not with diastolic HBP (aOR, 1.00 [95% CI, 0.54-1.85] and aOR, 0.87 [95% CI, 0.51-1.48]). Moreover, the linear relationships between amino acid intake at day 7 after birth or maximal plasma creatinine between day 3 and day 7, and systolic BP (adjusted β=1.61 mm Hg 1 g/kg of amino acid intake [95% CI, 0.28-2.93] and adjusted β=1.94 mm Hg per 50 μmol of creatinine [95% CI, 0.31-3.57], respectively) were significant (Figure S5B).…”

Section: Sensitivity Analysesmentioning

confidence: 98%

High amino-acid intake in early life is associated with systolic but not diastolic arterial hypertension at 5-years of age in children born very preterm

Rozé,

Bacchetta,

Lapillonne

et al. 2023

Preprint

View full text Add to dashboard Cite

BACKGROUND. The life course of individuals born very premature is a topic of increasing concern as their neonatal survival has dramatically increased. In a national, prospective, population-based birth cohort, EPIPAGE-2, we observed that amino-acid intakes greater than 3.5 g/kg/day at day 7 after birth were independently associated with higher intelligence quotient at 5 years. As the association between high early amino-acid intake and later HBP in this population is debated, we assessed blood pressure (BP) at 5 years. METHODS. This cohort was initiated in 2011, and approved by ethics committees. Eligible infants were those born between 24 and 29 weeks of gestation and alive on day7 after birth. Infants were distributed in two groups of 717 infants matched on propensity score on whether or not they were exposed to high amino-acid intake (>3.5 g/kg/d at Day7); 455 control term infants were also enrolled. Assessment at 5-year occurred from September 2016 to December 2017. A value > 95th percentile of reference values for age and height defined systolic and/or diastolic HBP. RESULTS. BP at five years of age was assessed for 389 and 385 children in exposed and non-exposed groups. Rates (%) of systolic HBP were 18.0% (95%CI, 14.5 to 22.2), 13.3% (95%CI, 10.3 to 17.0), and 8.5% (95%CI, 6.5 to 11.1) in exposed, non-exposed preterm infants, and term infants, respectively; and 9.0% (95%CI, 6.6 to 12.3), 10.2% (95%CI, 7.5 to 13.6), 5.4% (95%CI, 3.8 to 7.6) % for diastolic HBP, in exposed, non-exposed and term-born groups, respectively. Perinatal characteristics of exposed and non-exposed infants were similar, except for nutrition intake at day3 and day7 after birth. Exposure to high early amino-acid intake, and maximal serum creatinine between day3 and day7 were two independent risk factors for systolic HBP (aOR, 1.60 [95% CI, 1.05 to 2.43] and aOR, 1.59 [95% CI, 1.12 to 2.26] by 50 μmol/L, respectively) but not for diastolic HBP (aOR, 0.84 [95% CI, 0.50 to 1.39] and aOR, 1.09 [95% CI, 0.71 to 1.67] by 50 μmol/L, respectively). CONCLUSIONS. These observations confirm the risk for HBP in young children born very preterm. Higher amino-acid intake and creatinine values in the first week of life were associated with childhood systolic HBP. These results suggest that mechanisms to childhood systolic HBP involves neonatal renal challenge by high amino-acid intake or dysfunction.

show abstract

Effect of Protein Intake Early in Life on Kidney Volume and Blood Pressure at 11 Years of Age

Cited by 2 publications

References 25 publications

High Amino Acid Intake in Early Life Is Associated With Systolic but Not Diastolic Arterial Hypertension at 5 Years of Age in Children Born Very Preterm

High Amino Acid Intake in Early Life Is Associated With Systolic but Not Diastolic Arterial Hypertension at 5 Years of Age in Children Born Very Preterm

High amino-acid intake in early life is associated with systolic but not diastolic arterial hypertension at 5-years of age in children born very preterm

Contact Info

Product

Resources

About