Effect of protein restriction of bovine dams during late gestation on offspring postnatal growth, glucose-insulin metabolism and IGF-1 concentration

Maresca, Sebastian; Valiente, Sebastián López; Rodríguez, A. M.; Long, N. M.; Paván, E.; Quintans, G.

doi:10.1016/j.livsci.2018.04.009

Cited by 31 publications

(23 citation statements)

References 49 publications

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“…Glucose profiles are strongly linked with the short-term effect of the current energy and/or protein intake [30]. Furthermore, prenatal nutrient availability may influence the ability of calves to regulate glucose blood concentration during postnatal growing [48]. In our experiment, the lack of differences in glucose concentrations throughout rearing between CONTROL and SUBNUT heifers indicated that glucose metabolism was not affected in their postnatal lives.…”

Section: Heifer Metabolic and Endocrine Profilesmentioning

confidence: 61%

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Effects of Developmental Programming Caused by Maternal Nutrient Intake on Postnatal Performance of Beef Heifers and Their Calves

Noya

Casasús

Ferrer

et al. 2019

Animals

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In this study, we evaluated the effects of maternal subnutrition in early pregnancy on the growth and reproductive performance of female offspring during their rearing, first gestation, and lactation. We inseminated 21 Parda and 15 Pirenaica multiparous cows and assigned them to a CONTROL (100% of nutrition requirements) or SUBNUT (65%) diet until day 82 of gestation. Cows were fed 100% requirements afterward. During the rearing of female offspring, growth, physiological profiles and ovarian follicular dynamic were studied. At 16 months old, heifers were inseminated. After first calving, dam–calf weights were recorded during lactation. Heifers born from CONTROL cows were heavier at weaning (four months old) than heifers born from SUBNUT cows, but this difference disappeared at the end of rearing and during the first gestation and lactation periods. All heifers reached puberty at a similar age and live weight. During rearing, SUBNUT heifers had higher concentrations of non-esterified fatty acids, urea, and cholesterol and a lower antral follicle count than CONTROL, but no difference was found in their fertility rate. After heifer first calving, dam–calf weights were similar among groups. In conclusion, maternal undernutrition reduced offspring postnatal gains at weaning, compromising metabolic status and follicle population during rearing but did not impair performance in the first gestation and lactation periods of beef heifers.

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Section: Heifer Metabolic and Endocrine Profilesmentioning

confidence: 61%

“…Nutritional restriction during the fetal development might affect the IGF axis [48]. In a previous phase of this study, heifers from nutrient-restricted cows had lower IGF-1 concentrations than heifers from control cows at birth [15].…”

Section: Heifer Metabolic and Endocrine Profilesmentioning

confidence: 69%

Effects of Developmental Programming Caused by Maternal Nutrient Intake on Postnatal Performance of Beef Heifers and Their Calves

Noya

Casasús

Ferrer

et al. 2019

Animals

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“…Hoffman et al () found no differences in the glucose, triglyceride, and cholesterol concentrations in lambs born to poorly nourished ewes. Conversely, Maresca et al () described higher glucose concentrations during the first 60 days of life in calves whose mothers had received a low‐protein diet from mid‐gestation to parturition, supporting the hypothesis of Gardner et al () that maternal subnutrition during pregnancy could alter the capacity of calves to regulate plasma glucose concentrations during postnatal growth. However, glucose concentrations characterize nutritional status in the short term, and therefore the lack of differences in the current study could indicate that the newborns received a similar diet during their first days of life and their glucose metabolism was not altered.…”

Section: Resultsmentioning

confidence: 78%

“…Maternal undernutrition may reprogram the fetal IGF‐1 system in its ability to respond to acute changes in the substrate supply (Gallaher, Breier, Keven, Harding, & Gluckman, ). Similarly, fetal IGF‐1 concentration may be altered by maternal nutrition during the earlier stages of development (Rhind, ) and the level of protein intake from mid‐gestation to parturition can affect calf IGF‐1 at birth (Maresca et al, ). Accordingly, other authors found a greater reduction in IGF‐1 levels in the fetus (Gallaher et al, ) and in the lamb (Hoffman, Rokosa, Zinn, Hoagland, & Govoni, ) after maternal subnutrition in sheep.…”

Section: Resultsmentioning

confidence: 99%

Effects of maternal subnutrition during early pregnancy on cow hematological profiles and offspring physiology and vitality in two beef breeds

Noya

Serrano-Pérez

Mata

et al. 2019

Animal Science Journal

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This experiment evaluated the effects of subnutrition during early gestation on hematology in cows (Bos Taurus) and on hematological, metabolic, endocrine, and vitality parameters in their calves. Parda de Montaña and Pirenaica dams were inseminated and assigned to either a control (CONTROL, 100% requirements) or a nutrient‐restricted group (SUBNUT, 65%) during the first third of gestation. Dam blood samples were collected on days 20 and 253 of gestation, and calf samples were obtained during the first days of life. Pirenaica dams presented higher red series parameters than Parda de Montaña dams, both in the first and the last months of gestation. During early pregnancy, granulocyte numbers and mean corpuscular hemoglobin were lower in Pirenaica‐SUBNUT than in Pirenaica‐CONTROL cows. Calves from the SUBNUT cows did not show a physiological reduction in red series values in early life, suggesting later maturation of the hematopoietic system. Poor maternal nutrition affected calf endocrine parameters. Newborns from dystocic parturitions showed lower NEFA concentrations and weaker vitality responses. In conclusion, maternal nutrition had short‐term effects on cow hematology, Pirenaica cows showing a higher susceptibility to undernutrition; and a long‐term effect on their offspring endocrinology, SUBNUT newborns showing lower levels of IGF‐1 and higher levels of cortisol.

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“…Las vaquillonas HP tuvieron una mayor ganancia de peso vivo, sin embargo el peso vivo, la altura de la grupa y el grosor de la grasa de la costilla 12 fueron similares entre los tratamientos. En otras investigaciones no se observaron diferencias en ganancias de peso diarias en vaquillonas (Martin et al, 2007;Maresca et al, 2018) o novillos (Larson et al, 2009;Funston et al, 2010;Maresca et al, 2018) nacidos de vacas suplementadas con proteína durante gestación tardía. Las vaquillonas HP alcanzaron la pubertad a un peso vivo mayor en comparación con las vaquillonas LP (P = 0,01).…”

Section: Discussionunclassified

Primer Seminario Técnico de Programación Fetal

2019

INIA

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Los orígenes de la programación o desarrollo fetal en ganado vacuno y algunas áreas de investigación a futuro. Cuadro 1. Efecto de la subnutrición materna durante la gestación de vacas, sobre el crecimiento fetal, resultados publicados antes del año 2000. CAPÍTULO I: EFECTO DE LA RESTRICCIÓN NUTRICIONAL DURANTE LA GESTACIÓN SOBRE LA PROGENIE EN VACUNOS Efecto de la restricción proteica de vacas Angus durante la gestación tardía: rendimiento reproductivo posterior y producción de leche. Cuadro 1. Peso vivo y estado corporal durante el parto y posparto en vacas multíparas consumiendo dietas de bajo o alto contenido de proteína durante los 120 días previos al parto.

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Effect of protein restriction of bovine dams during late gestation on offspring postnatal growth, glucose-insulin metabolism and IGF-1 concentration

Cited by 31 publications

References 49 publications

Effects of Developmental Programming Caused by Maternal Nutrient Intake on Postnatal Performance of Beef Heifers and Their Calves

Effects of Developmental Programming Caused by Maternal Nutrient Intake on Postnatal Performance of Beef Heifers and Their Calves

Effects of maternal subnutrition during early pregnancy on cow hematological profiles and offspring physiology and vitality in two beef breeds

Primer Seminario Técnico de Programación Fetal

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