Effect of Proteoglycan Depletion on T2 Mapping in Rat Patellar Cartilage

Pinzano, Astrid; Ruaud, Jean-Pierre; Olivier, Pierre; Grossin, Laurent; Gonord, P.; Blum, Alain; Netter, Patrick; Guillot, Geneviève; Gillet, Pierre; Lœuille, Damien

doi:10.1148/radiol.2341030394

Cited by 82 publications

(64 citation statements)

References 32 publications

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“…The T2 of cartilage is one of the most commonly used MR imaging parameters and has been shown to be sensitive for detection of cartilage degeneration in ex vivo specimens (7) and human subjects (8)(9)(10)(11)(12). However, cartilage T2 is a complex measurement that is influenced by multiple factors including water and macromolecular content (13)(14)(15)(16), organization of the collagen fiber network (17)(18)(19), cartilage loading (20)(21)(22), and orientation of cartilage relative to the main magnetic field (23). Thus, changes in cartilage T2 may be difficult to interpret and sometimes challenging to detect because of the multiple potentially competing biologic factors that influence the measurement.…”

Section: Implication For Patient Carementioning

confidence: 99%

Articular Cartilage of the Human Knee Joint: In Vivo Multicomponent T2 Analysis at 3.0 T

Liu¹,

Choi²,

Samsonov³

et al. 2015

Radiology

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Section: Implication For Patient Carementioning

confidence: 99%

Articular Cartilage of the Human Knee Joint: In Vivo Multicomponent T2 Analysis at 3.0 T

Liu¹,

Choi²,

Samsonov³

et al. 2015

Radiology

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“…Prominent in these are: proton-based methods such as T 2 relaxation mapping (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20), delayed gadoliniumenhanced magnetic resonance imaging contrast (dGEM-RIC) (21,22), T 1r relaxation mapping (23)(24)(25)(26) and the direct MRI of sodium (27)(28)(29)(30). T 2 is predominantly affected by changes in collagen content and to a smaller extent in PG in the tissue.…”

Section: Osteoarthritismentioning

confidence: 99%

Sodium and T_1ρ MRI for molecular and diagnostic imaging of articular cartilage

et al. 2006

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In this article, both sodium magnetic resonance (MR) and T 1r relaxation mapping aimed at measuring molecular changes in cartilage for the diagnostic imaging of osteoarthritis are reviewed. First, an introduction to structure of cartilage, its degeneration in osteoarthritis (OA) and an outline of diagnostic imaging methods in quantifying molecular changes and early diagnostic aspects of cartilage degeneration are described. The sodium MRI section begins with a brief overview of the theory of sodium NMR of biological tissues and is followed by a section on multiple quantum filters that can be used to quantify both bi-exponential relaxation and residual quadrupolar interaction. Specifically, (i) the rationale behind the use of sodium MRI in quantifying proteoglycan (PG) changes, (ii) validation studies using biochemical assays, (iii) studies on human OA specimens, (iv) results on animal models and (v) clinical imaging protocols are reviewed. Results demonstrating the feasibility of quantifying PG in OA patients and comparison with that in healthy subjects are also presented. The section concludes with the discussion of advantages and potential issues with sodium MRI and the impact of new technological advancements (e.g. ultra-high field scanners and parallel imaging methods). In the theory section on T 1r , a brief description of (i) principles of measuring T 1r relaxation, (ii) pulse sequences for computing T 1r relaxation maps, (iii) issues regarding radio frequency power deposition, (iv) mechanisms that contribute to T 1r in biological tissues and (v) effects of exchange and dipolar interaction on T 1r dispersion are discussed. Correlation of T 1r relaxation rate with macromolecular content and biomechanical properties in cartilage specimens subjected to trypsin and cytokineinduced glycosaminoglycan depletion and validation against biochemical assay and histopathology are presented. Experimental T 1r data from osteoarthritic specimens, animal models, healthy human subjects and as well from osteoarthritic patients are provided. The current status of T 1r relaxation mapping of cartilage and future directions is also discussed. Copyright # 2006 John Wiley & Sons, Ltd. KEYWORDS: cartilage; arthritis; spin-lock; T1rho; sodium; MRI OSTEOARTHRITIS Osteoarthritis (OA) affects more than half of the population above the age of 65 (1,2) and has a significant negative impact on the quality of life of elderly individuals (3). The economic costs in the USA from OA have been estimated to be more than 1% of the gross domestic product (4). OA is now increasingly viewed as a metabolically active joint disorder of diverse etiologies. The biochemistry of the disease is characterized by the following changes in cartilage: reduced proteoglycan (PG) concentration, possible changes in the size of collagen fibril and aggregation of PG, increased water content and increased rate of synthesis and degradation of matrix macromolecules. The earliest changes in the cartilage due to OA result in a partial breakdown in the proteoglyc...

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“…It is sensitive to tissue anisotropy, and provides compositional information on the cartilage collagen network, water content and proteoglycans concentration (6). T2 mapping has been studied in both animal (7,8) and human knee cartilage models, especially in the femoropatellar Once a T2 prolongation was detected, a comparison with the con ventional MRI images (sagittal T1 weighted images and PDW with saturation of fat signal images) was performed by the 2 radiologists to retrospectively determine if T2 pro longations were linked to initially overlooked lesions in conventional MRI sequences.…”

mentioning

confidence: 99%

Correlation of MRI T2 mapping sequence with knee pain location in young patients with normal standard MRI

Dautry

Bousson

Manelfe

et al. 2014

Journal of the Belgian Society of Radiology

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Effect of Proteoglycan Depletion on T2 Mapping in Rat Patellar Cartilage

Abstract: In rat patellar cartilage, T2 mapping permits detection of slight or severe proteoglycan depletion and concurrent changes of extracellular matrix when age-matched samples are compared.

Cited by 82 publications

References 32 publications

Articular Cartilage of the Human Knee Joint: In Vivo Multicomponent T2 Analysis at 3.0 T

Articular Cartilage of the Human Knee Joint: In Vivo Multicomponent T2 Analysis at 3.0 T

Sodium and T_1ρ MRI for molecular and diagnostic imaging of articular cartilage

Correlation of MRI T2 mapping sequence with knee pain location in young patients with normal standard MRI

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Effect of Proteoglycan Depletion on T2 Mapping in Rat Patellar Cartilage

Abstract: In rat patellar cartilage, T2 mapping permits detection of slight or severe proteoglycan depletion and concurrent changes of extracellular matrix when age-matched samples are compared.

Cited by 82 publications

References 32 publications

Articular Cartilage of the Human Knee Joint: In Vivo Multicomponent T2 Analysis at 3.0 T

Articular Cartilage of the Human Knee Joint: In Vivo Multicomponent T2 Analysis at 3.0 T

Sodium and T1ρ MRI for molecular and diagnostic imaging of articular cartilage

Correlation of MRI T2 mapping sequence with knee pain location in young patients with normal standard MRI

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Product

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Sodium and T_1ρ MRI for molecular and diagnostic imaging of articular cartilage