Effect of psoriasis therapy on VEGF and its soluble receptors serum concentrations

Abstract

We confirmed the association between psoriasis activity and serum VEGF concentrations, which can be recognized as an indicator of the disease severity. However, the increase of serum sVEGF R1 concentrations can predict amelioration of clinical signs.

Effect of psoriasis activity on epidermal growth factor (EGF) and the concentration of soluble EGF receptor in serum and plaque scales

“…As we reported previously, some inflammatory cytokines and their soluble receptors [transforming growth factor (TGF)-b1 and vascular endothelial growth factor] are involved in the pathogenesis of psoriasis. 3,4 The factor that appears to play a crucial role in the pathogenesis of psoriasis is epidermal growth factor (EGF). 5 EGF receptors (EGFRs) are overexpressed in epidermal keratinocytes in psoriatic lesions, and regulate cell growth, proliferation and differentiation through binding to EGF.…”

Erythrodermic Psoriasis Improved by Panitumumab, But Not Bevacizumab

“…Levels of Letters to the Editor 361 VEGF have also been shown to be increased in plasma and skin lesions of psoriasis (1)(2)(3)(4), contributing to dermal vascularization. The VEGF level correlates with disease severity ofthe psoriasis (7,8). The present case suggests that EGFR signalling contributes greatly to the development of psoriatic skin lesions, since panitumumab, an anti-EGFR antibody, exhibited remarkable therapeutic effects on skin symptoms in the erythrodermic psoriasis patient.…”

The Role of Angiogenesis in the Pathogenesis of Psoriasis: Mechanisms and Clinical Implications

“…There is a correlation between VEGF concentrations and PASI scores both before and after treatments with psoralen-ultraviolet A (PUVA) and acitretin [47]. Topical treatments for 14 days with 5% salicyl ointment for desquamation and then with 0.3% dithranol ointment also reduced VEGF concentrations in psoriatic patients [48]. These treatments having a positive impact on dermis microcirculation within scales are not an exception.…”

“…Indeed, VEGF was found in higher concentration in serum of psoriatic patients in comparison to healthy patients [47,48]. There is a correlation between VEGF concentrations and PASI scores both before and after treatments with psoralen-ultraviolet A (PUVA) and acitretin [47].…”