Effect of psychological stress on fertility hormones and seminal quality in male partners of infertile couples

Bhongade, Megha; Prasad, Sudha; Jiloha, RC; Ray, P. C.; Mohapatra, Sumant Kumar; Koner, Bidhan Chandra

doi:10.1111/and.12268

Cited by 110 publications

(96 citation statements)

References 22 publications

(24 reference statements)

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“…Seventy infertile male partners were investigated as for psychological stress levels using Anxiety and Depression Scale scoring system and with measurements of total serum testosterone, serum GnRH, FSH, LH levels and spermiograms. The researchers indicated that psychological stress firstly lowers serum total testosterone levels, and secondarily increases serum LH and FSH levels, which suggest that stress management might have an important place in male infertility (17). We included only infertile male patients in our study and found depression rates in primary and secondary infertile groups as 22 and 38%, respectively.…”

Section: Discussionmentioning

confidence: 95%

Psychologic and sexual dysfunction in primary and secondary infertile male patients

Şahin¹,

Ürkmez²,

Verit³

et al. 2017

Arch Ital Urol Androl

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Objective: The aim of this study was to compare depression and sexual dysfunctions observed in primary and secondary infertile patients. Material and method: The study was performed in 39 primary and 31 secondary infertile male patients. Male sexual health was evaluated using the International Index of Erectile Function (IIEF) score and depression with Beck Depression Inventory (BDI). Results: Mean age of the participants and their partners were 31.54 ± 5.37 (range, 24-48 yrs), and 28.16 ± 5.58 (range, 20-46 yrs) years, respectively. Mean duration of their marriage ranged between 1 and 17 years (mean, 5.06 ± 4.15 yrs). A statistically significant intergroup difference was detected between groups as for BDI scores (p = 0.015; p < 0. 05). BDI scores of the primary group were significantly lower than those of the secondary group. A statistically and extremely significant difference was detected between IIEF scores of the groups (p = 0.006; p < 0.01). IIEF scores of the primary infertile group were higher than those of the secondary group. Conclusion: Our study, frequency of the depression and erectile dysfunction seen in the patients with secondary infertility was seen significantly higher than the patients with primary infertility.KEY WORDS: Infertility; Male sexual dysfunction; Depression; Secondary infertile man. clear definition of this time, the 12 months period is also accepted for the secondary infertility by many authors. Diagnosis of infertility can be made in nearly 15% of the couples who want to have a baby and primary or secondary infertility are detected in 90 and 10% of them (3). One of the basic and primitive instincts in human beings is reproductive instinct. Reproductive deficiency frequently creates a social stigma, which is perceived as a disgraceful condition (4). Infertility emerges from a sudden and unexpected life crisis, which can be diagnosed in the long run. It results in excessive stressful problems, which strain adjustment mechanisms (5). Studies analyzing the association between infertility and psychological functions have used one of the following models. One of them is psychological infertility model, which asserts the role of an existing psychopathology on the etiology of infertility and the other model (psychological result) claims that psychological problems arise as a result of infertility (6). Recently direct correlation of mental stress with infertility problems and its impact on the outcomes of infertility treatment has been demonstrated. For example it has been revealed that during natural disasters like earthquakes, sperm quality activities of seminal plasma superoxide dismutase and arginine decrease, and nitric oxide levels increase in men under stress (7,8). Since psychiatric disorders are more frequently analyzed during infertility investigations, scales specific to infertility process haven't been developed yet (9). In developed countries, it appears to be appropriate to take a detailed history about psychological status of the infertile couple. The rationale of this appr...

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Section: Discussionmentioning

confidence: 95%

Psychologic and sexual dysfunction in primary and secondary infertile male patients

Şahin¹,

Ürkmez²,

Verit³

et al. 2017

Arch Ital Urol Androl

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“…Semua perasaan yang tidak menyenangkan itu jika berlaku secara kronik boleh mengganggu fungsi tubuh (Chrousos et al 2013). Stres yang berpanjangan boleh menyebabkan perubahan kepada keseimbangan hormon testosteron dalam badan (Levi 2013) yang mengganggu pembentukan sperma (Bhongade et al 2015).…”

Section: Pengenalanunclassified

“…Kajian terdahulu menyatakan stres meninggalkan implikasi negatif dalam pelbagai parameter yang berkait rapat dengan kualiti semen termasuk kepekatan sperma, motiliti dan morfologi (Bhongade et al 2015). Kajian kesan stres terhadap organ pembiakan manusia dan kualiti semen telah mendapat perhatian meluas sejak dahulu lagi (Barazani et al 2014).…”

Section: Pengenalanunclassified

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Kesan Psikostres terhadap Kerosakan DNA dan Ketaknormalan Titisan Sitoplasma Sperma Manusia

Hashim

Osman²,

Ibrahim³

et al. 2016

JSM

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“…Современные исследования показывают, что бесплодие приводит к стрессу, и в свою очередь стресс признан возможной причиной пато-спермии [1][2][3]. Диагноз «бесплодие» является провоцирующим фактором для депрессивного состояния.…”

unclassified

Selective serotonin reuptake inhibitor and fertility potential of the men. Psychiatry and Urology. At the junction of related disciplines

Коршунов

Коршунова²

2016

UroVed

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¹ Кафедра урологии ФГБУ ДПО «Центральная государственная медицинская академия» УДП РФ, Москва;² ФГБУ «Национальный медицинский исследовательский радиологический центр» МЗ РФ, Москва; 3 ГБУ «Научно-исследовательский институт организации здравоохранения и медицинского менеджмента ДЗМ», Москва; 4 Российско-немецкий центр репродукции и клинической эмбриологии ООО «Поколение Некст», Москва Введение. Бесплодие приводит к эмоциональному стрессу, что может стать фактором депрессии. В свою очередь стресс также признан одной из возмож-ных причин патоспермии и бесплодного брака. Целью пилотного исследования стала оценка влияние селективных ингибиторов обратного захвата серотонина (СИОЗС) на сперматогенез и фертильный потенциал в лечении пациентов с де-прессией. Материалы и методы. Исследование включило 19 фертильных муж-чин с депрессией средней степени выраженности. Данных за урологическую па-тологию выявлено не было. Пациентам был назначен флуоксетин в дозе 20 мг в сутки в течение 6 недель. Спермиологическое исследование (ВОЗ 2010), пока-затель фрагментации ДНК сперматозоидов оценены до, после окончания терапии и через 3 месяца после отмены препарата. Результаты. Все наблюдаемые имели нормальные показатели спермограммы и ДНК-фрагментации до лечения. Через 6 недель лечения мы зафиксировали снижение всех параметров спермограммы и увеличение индекса фрагментации ДНК сперматозоидов. Через 3 месяца после окончания терапии средний объем эякулята, концентрация, подвижность и про-цент нормальных форм сперматозоидов увеличились и практически вернулись к исходным цифрам. Средний показатель фрагментации ДНК снизился и имел значение меньшее, чем до назначения СИОЗС, что положительно коррелировало с динамикой симптомов депрессии. Выводы. Использование СИОЗС может не-гативно влиять на сперматогенез и фертильность мужчины в течение лечения. Наиболее выраженные изменения зарегистрированы в отношении морфологии и целостности структуры ДНК половых клеток. Через 3 месяца после отмены препарата отмечается возврат показателей к исходным значениям. Требуются дальнейшие исследования для оценки влияния СИОЗС в лечении бесплодных мужчин с депрессией. Introduction. Iinfertility leads to emotional stress, which is a precipitating factor of depression. Stress has also been recognized as one of possible reasons of pathospermia and infertility. The aim of pilot study: to evaluate SSRIs effects on spermatogenesis and fertility in the treatment of depression. Material and Methods. Study included 19 fertile men with depression of mild severity. None of them had any urological disorders. They were treated by fluoxetine 20 mg per day during 6 weeks. Semen analysis (WHO 5), level of DNA fragmentation were performed before, after the therapy and 3 months of drug discontinuation. Results. All the men had normal semen parameters and level of DNA fragmentation before the treatment. After 6 weeks of the treatment, we fixed the reduction of sperm´s parameters and increasing the level of DNA fragmentation. After 3 mounts of drug discontinuation the mean semen volu...

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Effect of psychological stress on fertility hormones and seminal quality in male partners of infertile couples

Cited by 110 publications

References 22 publications

Psychologic and sexual dysfunction in primary and secondary infertile male patients

Psychologic and sexual dysfunction in primary and secondary infertile male patients

Kesan Psikostres terhadap Kerosakan DNA dan Ketaknormalan Titisan Sitoplasma Sperma Manusia

Selective serotonin reuptake inhibitor and fertility potential of the men. Psychiatry and Urology. At the junction of related disciplines

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