Effect of psyllium on gastric emptying, hunger feeling and food intake in normal volunteers: a double blind study

Rigaud, Daniel; Paycha, Frédéric; Meulemans, Ann; Merrouche, M.; Mignon, M

doi:10.1038/sj.ejcn.1600518

Cited by 106 publications

(68 citation statements)

References 29 publications

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“…However, and in agreement with Fernández et al (1998), García et al (2000) and Rigaud et al (1998), we think that these changes principally occur because the fiber forms a highly viscous solution, trapping levodopa inside it, and therefore, there is a decrease in drug absorption in the intestine and consequently lower values for C max are obtained.…”

Section: Discussionsupporting

confidence: 91%

“…Nevertheless, other authors did not find this action: Bianchi and Capurso (2002) demonstrated that the addition of different dietary fibers (guar gum and ispaghula) to a solid meal did not influence gastric emptying. Frost et al (2003) probed that psyllium-enriched pasta had no significant effect on gastric emptying and Rigaud et al (1998) concluded that psyllium did not slow down the gastric emptying of hydrosoluble nutrients, but increased the time allowed for intestinal absorption.…”

Section: Discussionmentioning

confidence: 99%

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Hydrosoluble fiber (Plantago ovata husk) and levodopa I: Experimental study of the pharmacokinetic interaction

García¹,

Fernández²,

Carriedo³

et al. 2005

European Neuropsychopharmacology

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Fiber therapy could be used in patients with Parkinson disease to reduce the symptoms of gastrointestinal disorders; however, it could interact with levodopa reducing its effectiveness. In this experimental study we have investigated whether the presence of Plantago ovata husk (water-soluble fiber) modifies in rabbits the bioavailability and other pharmacokinetic parameters of levodopa (20 mg/kg) when administered by the oral route at the same time. We have also studied whether pharmacokinetic modifications are fiber-dose dependent (100 and 400 mg/kg). The extent of levodopa absorbed when administering 100 mg/kg of fiber (AUC = 43.4 Ag min ml À 1 ) is approximately the same as when levodopa is administered alone (AUC = 47.1 Ag min ml À 1 ); however, C max is lower (1.04 versus 1.43 Ag ml À 1 ). Results obtained indicate that fiber at the higher dose increases the extent of levodopa absorbed (AUC = 62.2 Ag min ml À 1 ), being the value of C max similar (1.46 Ag ml À 1 ). The value of t max increases from 10 min when levodopa is administered alone to 20 min when the animals receive fiber. On the other hand, since certain time on, levodopa concentrations are always higher in the groups that receive fiber: 60 min with 100 mg/kg fiber and 20 min with 400 mg/kg fiber. Fiber also increases the mean residence time (MRT). P. ovata husk administration with levodopa could be beneficial, not only in patients with constipation, due to: lower adverse reactions (lower values of C max ) and longer and more stable effects (higher final concentrations and more time in the body). D

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Hydrosoluble fiber (Plantago ovata husk) and levodopa I: Experimental study of the pharmacokinetic interaction

García¹,

Fernández²,

Carriedo³

et al. 2005

European Neuropsychopharmacology

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“…This last fact is important because, due to the relatively short duration of this study, fructosamine is a better marker than GhbA 1c . This reduction might be due to psyllium's ability to reduce hunger feelings and energy intake (Rigaud et al, 1998). We have no data available from other authors about how psyllium modifies these parameters.…”

Section: Discussionmentioning

confidence: 90%

Therapeutic effects of psyllium in type 2 diabetic patients

et al. 2002

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Objective: The aim of this study was to evaluate the effects of psyllium in type 2 diabetic patients. Design: The study included three phases: phase 1 (1 week), phase 2 (treatment, 14 g fibre=day, 6 weeks) and phase 3 (4 weeks). At the end of each phase a clinical evaluation was performed after the ingestion of a test breakfast of 1824.2 kJ (436 kcal). Measurements included concentrations of blood glucose, insulin, fructosamine, GHbA 1c , C-peptide and 24 h urinary glucose excretion. In addition, uric acid, cholesterol and several mineral and vitamin concentrations were also evaluated. Setting: The study was performed at the Department of Pharmacology, Toxicology and Nursing at the University of Leó n (Spain). Subjects: Twenty type 2 diabetic patients (12 men and 8 women) participated in the study with a mean age of 67.4 y for men and 66 y for women. The mean body mass index of men was 28.2 kg=m 2 and that of women 25.9 kg=m 2 . Results: Glucose absorption decreased significantly in the presence of psyllium (12.2%); this reduction is not associated with an important change in insulin levels (5%). GHbA 1c , C-peptide and 24 h urinary glucose excretion decreased (3.8, 14.9 and 22.5%, respectively) during the treatment with fibre (no significant differences) as well as fructosamine (10.9%, significant differences). Psyllium also reduced total and LDL cholesterol (7.7 and 9.2%, respectively, significant differences), and uric acid (10%, significant difference). Minerals and vitamins did not show important changes, except sodium that increased significantly after psyllium administration. Conclusions:The results obtained indicate a beneficial therapeutic effect of psyllium (Plantaben 1 ) in the metabolic control of type 2 diabetics as well as in lowering the risk of coronary heart disease. We also conclude that consumption of this fibre does not adversely affect either mineral or vitamin A and E concentrations. Finally, for a greater effectiveness, psyllium treatment should be individually evaluated.

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“…Most notably, the results of many studies conducted on humans showed that psyllium reduces caloric consumption while improving satiety. [28][29][30] The action of psyllium on caloric intake and satiety could result from its capacity to increase chyme viscosity, which slows down gastric emptying, as shown previously in humans 28 and dogs. 31 To assess the relative effects of both fiber and protein supplementation most appropriately, 4 similarly formulated diets would have been needed, which only differed in fiber and protein content (eg, HPHF, HP only, HF only, and neither HP nor HF).…”

Section: Discussionmentioning

confidence: 99%

A High‐Protein, High‐Fiber Diet Designed for Weight Loss Improves Satiety in Dogs

Weber

Bissot

Servet

et al. 2007

Veterinary Internal Medicne

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Background: Weight-loss programs for dogs are often hampered by increased begging and scavenging behavior that ensues when food intake is restricted.Hypothesis: A diet formulated to contain a high content of both protein and fiber is more satiating than diets that contain only high fiber or high protein.Animals: Six entire female adult dogs (2 Shetland Sheepdogs, 2 Brittany Spaniels, 2 Labrador Retrievers) participated in the satiety studies; 105 adult female dogs of various breeds and ages were used for the palatability studies.Methods Voluntary food intake was measured in 5 sequential crossover studies, and palatability was assessed with food preference tests.Results: Protein digestibility was significantly lower for HF (mean 6 SD; 77.7% 6 2.52%) than for both HPHF (81.1% 6 0.96%) and HP (81.1% 6 1.65%) (P , .001). Short-term food intake (food ingested when offered for 15 minutes every hour for 4 hours) was lower for HPHF than for both HP and HF (P 5 .038). Medium-term intake (food ingested when offered 3 hours after first meal) was lower for both HPHF (27 6 22.2 kcal/kg 0.73 ) and HF (41 6 6.8 kcal/kg 0.73 ) than for HP (57 6 18.8 kcal/kg 0.73 ) (P 5 .041). Voluntary food intake 3 hours after feeding a restricted meal (25% daily maintenance energy requirements) was significantly lower on the HPHF diet than on either the HP (251%, P 5 .0051) or HF (247%, P 5 .014) diets. However, there was no significant difference between the energy intake on the HP and HF diets (7%, P 5 .37). The HPHF and HP diets had equivalent palatability, and both were more palatable than the HF diet (P , .001).Conclusions and Clinical Importance: The HPHF diet had a satiating effect as evidenced by reduced voluntary intake compared with HP and HF diets, and has the potential to lead to greater compliance in weight-loss programs.

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Effect of psyllium on gastric emptying, hunger feeling and food intake in normal volunteers: a double blind study

Cited by 106 publications

References 29 publications

Hydrosoluble fiber (Plantago ovata husk) and levodopa I: Experimental study of the pharmacokinetic interaction

Hydrosoluble fiber (Plantago ovata husk) and levodopa I: Experimental study of the pharmacokinetic interaction

Therapeutic effects of psyllium in type 2 diabetic patients

A High‐Protein, High‐Fiber Diet Designed for Weight Loss Improves Satiety in Dogs

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