Effect of pulsed infrared lasers on neural conduction and axoplasmic transport in sensory nerves

Wesselmann, Ursula; Rymer, William Z.; Lin, Shien-Fong

doi:10.1117/12.17474

Cited by 2 publications

(1 citation statement)

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“…To support our data, Wesselmann and collaborators demonstrated the effect of Q-switched Nd:YAG 1064-nm irradiated through increasing pulse energies ranging from 10 to 100 mJ/pulse for 5 min each on C fiber, which is involved in nociception and pain of peroneal tibial and saphenous nerve models. The nociceptor activity was suppressed [49]. Additionally, Wesselmann and collaborators showed ultrastructural changes of axonal organelles in nonmyelinated fibers after irradiation with 1064-nm Q-switched Nd:YAG laser (70 mJ, 10 Hz, 8 ns pulse duration, 5 min irradiation).…”

Section: Discussionmentioning

confidence: 98%

The 1064-nm Nd:YAG Photobiomodulation vs. 20% Benzocaine Topical Gel in Inducing Mucosal Anesthetic Effect: A Double-Blind Randomized Clinical Trial

et al. 2022

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The periapical local anesthetic injection may be associated with fear of needles and pain administration. Dental topical anesthetic agents can help to reduce pain perception; however, adverse events can occur. To investigate the efficacy of 1064-nm photobiomodualtion (PBM) in inducing mucosal anesthesia delivered with a flat-top hand-piece compared to 20% Benzocaine topical anesthetic gel, sixty healthy patients were randomly allocated (1:1) to either 20% benzocaine topical gel + placebo laser (T group) or PBM + placebo gel (L group). The 1064-nm Nd:YAG laser was employed and is associated with a novel flat-top hand piece. The applied operational parameters were 0.5 W, 10 Hz, 100 µs pulse width, and 30 J/cm2 for one-minute single application time. The enrolled subjects were asked to assess pain intensity at the time of anesthetic injection with a Visual Analog Scale. Taking into consideration taste, undesirable numbness, and overall satisfaction, the patients were asked to rate their experiences according to a verbal rating scale. Statistical analysis showed no statistically significant difference between the T and L Groups for pain ratings (p = 0.0596). The L Group displayed significantly higher ratings than T Group for taste, undesirable numbness, and overall satisfaction (p < 0.001). The 1064-nm PBM delivered by flat-top hand piece is effective in inducing mucosal anesthesia, eliminating the adverse side-effects of the conventional topical anesthetic gel.

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Section: Discussionmentioning

confidence: 98%