Effect of pumpkin-seed oil on the level of free radical scavengers induced during adjuvant-arthritis in rats

Fahim, Atef T.; Fattah, Amal A. Abd-El; Agha, Azza M.; Gad, Mohamed Z.

doi:10.1016/1043-6618(95)80051-4

Cited by 73 publications

(43 citation statements)

References 36 publications

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“…Fahim et al (51) reported that pumpkin seed oil significantly inhibited adjuvantinduced arthritis in rats, similar to a well-known antiinflammatory substance called indomethacin. It may well be considered that the supplementation of natural components with standard drugs might give synergistic, antagonistic and no-change effects (called drug interaction effects) during treatment of diseased conditions.…”

Section: Other Medicinal Effectsmentioning

confidence: 99%

“…It may well be considered that the supplementation of natural components with standard drugs might give synergistic, antagonistic and no-change effects (called drug interaction effects) during treatment of diseased conditions. Similarly, Fahim et al (51) tested the drug interaction effects of pumpkin seed oil with indomethacin and they found no effect in the adjuvantinduced arthritis model in rats. Pumpkin seed oil has potential hypotensive activity, as suggested by Zuhair et al (52) .…”

Section: Other Medicinal Effectsmentioning

confidence: 99%

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Medicinal and biological potential of pumpkin: an updated review

et al. 2010

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The use of herbal remedies individually or in combination with standard medicines has been used in various medical treatises for the cure of different diseases. Pumpkin is one of the well-known edible plants and has substantial medicinal properties due to the presence of unique natural edible substances. It contains several phyto-constituents belonging to the categories of alkaloids, flavonoids, and palmitic, oleic and linoleic acids. Various important medicinal properties including anti-diabetic, antioxidant, anti-carcinogenic, anti-inflammatory and others have been well documented. The purpose of the present article is to discuss various medicinal and biological potentials of pumpkin that can impart further research developments with this plant for human health benefits.

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Section: Other Medicinal Effectsmentioning

confidence: 99%

Section: Other Medicinal Effectsmentioning

confidence: 99%

Medicinal and biological potential of pumpkin: an updated review

et al. 2010

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“…The most critical health benefit attributed to pumpkin seed oil is preventing the growth and reducing the size of the prostate (67,68). There is also evidence that suggests pumpkin seed oil can retard the progression of hypertension (69) and mitigate hypercholesterolemia (70) and arthritis (71). Reduced bladder and urethral pressure and improved bladder compliance have been linked to pumpkin seed lipid components (72)(73)(74)(75).…”

Section: Introductionmentioning

confidence: 99%

Oil and Tocopherol Content and Composition of Pumpkin Seed Oil in 12 Cultivars

Stevenson

Eller

Wang

et al. 2007

J. Agric. Food Chem.

344

232

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Twelve pumpkin cultivars (Cucurbita maxima D.), cultivated in Iowa, were studied for their seed oil content, fatty acid composition, and tocopherol content. Oil content ranged from 10.9 to 30.9%. Total unsaturated fatty acid content ranged from 73.1 to 80.5%. The predominant fatty acids present were linoleic, oleic, palmitic, and stearic. Significant differences were observed among the cultivars for stearic, oleic, linoleic, and gadoleic acid content of oil. Low linolenic acid levels were observed (<1%). The tocopherol content of the oils ranged from 27.1 to 75.1 μg/g of oil for α-tocopherol, from 74.9 to 492.8 μg/g for γ-tocopherol, and from 35.3 to 1109.7 μg/g for δ-tocopherol. The study showed potential for pumpkin seed oil from all 12 cultivars to have high oxidative stability that would be suitable for food and industrial applications, as well as high unsaturation and tocopherol content that could potentially improve the nutrition of human diets. Keywords: Pumpkin seed oil; pumpkin seed; oilseed; winter squash; Cucurbitaceae; fatty acid; tocopherol

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“…Few reports showed that it could be due to the decreased sympathetic tonicity of the vessels (Boston et al, 2004), changes in beta-adrenergic receptors profile (Botrel et al, 1994), and the decrease in knee vessels in response to phenylephrine and overproduction of nitric oxide (NO). It has been revealed that this change is due to the altered secretion and release of local vessels relaxating mediators from the inflamed cells or sensory nerve ends, whereas calcitonin gene-related peptide (CGRP) and substance P that are released from the sensory nerves ends, caused the neurogenic dilatation of the vessels (Fahim et al, 1995). In addition, increase in the release of substance P, is possible.…”

Section: Introductionmentioning

confidence: 99%

“…One of the leading causes of the raised temperature is the increased joint blood flow accompanied by some of the chemical mediators that are released in the site of inflammation (Fahim et al, 1995). Therefore, the factors that reduce the blood flow of joint or inhibit the production and release of mediators down regulate the joint temperature in inflammation.…”

Section: Introductionmentioning

confidence: 99%

Calcium channel blockers attenuate chronic inflammation in rat knee joints

Rahmani¹,

Allahtavakoli²,

Mahmoodi³

et al. 2013

Afr. J. Pharm. Pharmacol.

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Previous studies demonstrated therapeutic effects for calcium channel blockers (CCBs) in control of acute inflammation. There are little reports on the effect of these blockers on chronic inflammation. In this study, we investigated the effects of CCBs on chronic inflammation using complete Ferund's adjuvant (CFA) induced inflammation in the rat knee joints. This experimental study was carried out on 80 male Wistar rats. Calcium channel blockers (verapamil and nifedipine) were used in doses of 100 and 800 µg/kg. For induction of chronic inflammation, CFA (0.2 ml) was injected into the right knee joint. The changes in blood flow, and local temperature of the animal's knee joint were measured by laser Doppler flowmetry and also the knee diameter was measured by a caliper, on 0, 7, 14, 21, and 28 days after CFA injection. CFA injection significantly increased blood flow from day 1 to 28 as compared to the day 0. Administration of both verapamil and nifedipine (100 and 800 µg/kg) significantly decreased the effect of CFA on increasing blood flow (all p < 0.05). Administration of both verapamil and nifedipine (100 and 800 µg/kg) significantly inhibited the effect of CFA on increasing knee temperature (all p < 0.05). Injection of CFA increased the knee joint diameter for all 28 days after injection. Both low and high doses of nifedipine and verapamil could inhibit the increased diameter that is induced by CFA injection (all p < 0.05). The effects of CCBs on measured parameter were comparable with the effect of ibuprofen (which is a standard anti-inflammatory drug) on these parameters. The results revealed that CCBs inhibited the increased rat knee blood flow, diameter and temperature in chronic inflammation induced by CFA. Therefore, the underlying mechanisms for reduction of chronic inflammation possibly are modulated by these blockers.

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Effect of pumpkin-seed oil on the level of free radical scavengers induced during adjuvant-arthritis in rats

Cited by 73 publications

References 36 publications

Medicinal and biological potential of pumpkin: an updated review

Medicinal and biological potential of pumpkin: an updated review

Oil and Tocopherol Content and Composition of Pumpkin Seed Oil in 12 Cultivars

Calcium channel blockers attenuate chronic inflammation in rat knee joints

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