Effect of Purple Passion Fruit Extract Cream (Passiflora edulis Sims var. Edulis) 6% against Striae Distensae

Abstract

ABSTRACT
 Background: Striae distensae is a skin disorder that causes cosmetic and psychological problems. Purple passion fruit (Passiflora edulis Sims var. Edulis) is widely cultivated, especially in North Sumatra. The seeds are abundant and unused industrial waste. Purple passion fruit seeds contain piceatannol, ascorbic acid, flavonoids, resveratrol, hydroalcohols and sterols which play a role in the repair of striae distensae through anti-inflammatory mechanisms, increase fibroblast proliferation and collagen production, increase crosslinking between collagen fibers and moisturizers.
 Objective: To determine the effect of 6% purple passion fruit (Passiflora edulis Sims var. Edulis) seed extract cream on striae distensae.
 Subjects and Methods: This study is a pre-experimental clinical trial with a pretest-posttest research design on 40 subjects with striae distensae. Diagnosis was confirmed by history and clinical evaluation using the Manchester scar scale before and after administration of 6% purple passion fruit extract cream at weeks 0, 2, 4, 6, 8. Adverse effects were recorded during the study and satisfaction levels were assessed at the end.
 Results: The majority of subjects' ages ranged from 29 to 39 years (72.5%). There was a significant reduction in Manchester scar scale in striae distensae, both after being given a 6% purple passion fruit extract cream or a combination of 1% tretinoin cream for 8 weeks, with a mean reduction of 25% (p = 0.000). Striae distensae after being given 6% purple passion fruit extract cream compared to 6% purple passion fruit extract cream combined with 1% tretinoin cream, there was no significant difference (p = 0.791). From a total of 40 subjects, none experienced side effects (0%). As many as 57.5% of the subjects showed a good level of satisfaction.
 Conclusion: The use of 6% purple passion fruit seed extract cream can improve the appearance of striae distensae without side effects and the level of satisfaction is good.
 

Constituent Characteristics and Functional Properties of Passion Fruit Seed Extract

“…P. edulis seed extract exhibits antibacterial activity against Propionibacterium acnes [78], and this antibacterial activity of the extract may have contributed to the improvement of acne vulgaris in the human studies. In addition, another human study demonstrated that application of a cream containing 6% P. edulis seed extract improved the symptoms of striae distensae, a common form of skin scarring [79]. Evidently, P. edulis seed extract can contribute to the improvement of skin disorders such as acne vulgaris and striae distensae when applied to the skin.…”

Assessing the safety and use of medicinal herbs during pregnancy: a cross-sectional study in São Paulo, Brazil

“…Although no side effects have been reported from the topical use of its cream, limited scientific evidence is available regarding its use and safety among pregnant women Aryunisari et al (2021).…”

A pilot study of new scoring system severity of striae distensae

“…Striae distensae mostly occurs in puberty (6% -86%) and obesity (43%). [1][2][3][4][5][6][7] Striae distensae can arise from several causes, including rapid changes in body weight, adolescent growth, use of corticosteroids, Cushing's syndrome, and commonly appearing on the buttocks, thighs, knees, lumbosacral region, breasts and upper arms in men. The mechanism associated with the formation of SD is not completely understood, but this disorder is the result of connective tissue discontinuity, which leads to atrophy of the dermis.…”