Effect of purslane on blood lipids and glucose: A systematic review and meta‐analysis of randomized controlled trials

Abstract

Despite a history of purslane usage as a herbal treatment for dyslipidemia and hyperglycemia management, existing evidence from clinical trials is controversial. The aim for the current study was to evaluate the efficacy of purslane supplementation on lipid parameters and glycemic status in adult populations. A systematic review was conducted in PubMed, Scopus, ISI Web of Science, and Google Scholar up to January 15, 2018, searching for randomized controlled trials that assessed the impact of purslane on fasting blood glucose (FBG), triglycerides, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C).Based on the detected heterogeneity between studies, a random-or fixed-effect model was applied in the meta-analysis. The findings from six randomized controlled trials, comprising 352 participants, indicated that purslane can reduce FBG (−4.54 mg/ dl, 95% CI [−7.54, −1.53]; I 2 = 0.53%) and triglycerides ; I 2 = 0%) levels. Changes in TC, LDL-C, and HDL-C concentrations did not reach a statistically significant level. Subgroup analysis showed a favorable effects of purslane on FBG, triglycerides, TC, and LDL-C in a subset of studies in which purslane was administered >1.5 g/day. Categorization based on gender showed that purslane was more effective in improving FBG, TC and LDL-C in females compared with males. This systematic review and meta-analysis suggested that the purslane might be effective on the improvement of blood lipid and glucose levels. Further robust studies with sufficient durations and dosages of supplementation are needed to confirm these results.

The efficacy of propolis on markers of glycemic control in adults with type 2 diabetes mellitus: A systematic review and meta‐analysis

“…Similar to human studies, investigations on animal species revealed that propolis and its ingredient are safe and do not cause any toxic changes in the liver and kidneys (Celik & Erdogan, ; Jung et al, ; Türkez, Yousef, & Geyikoglu, ). Although propolis, like many alternative remedies, is generally better tolerated than synthetic medications (A. Hadi, Pourmasoumi, Najafgholizadeh, Kafeshani, & Sahebkar, ; Izzo, Hoon‐Kim, Radhakrishnan, & Williamson, ; Mansour‐Ghanaei, Hadi, Pourmasoumi, Joukar, Golpour, & Najafgholizadeh, ), several studies have suggested that propolis had the potential for allergic reactions in certain people. It might cause skin to redden or rashes to develop, itch, and swell.…”

Does turmeric/curcumin supplementation improve serum alanine aminotransferase and aspartate aminotransferase levels in patients with nonalcoholic fatty liver disease? A systematic review and meta‐analysis of randomized controlled trials

“…Although the facts showed that herbal remedies are generally better tolerated than synthetic medications (Baghernya, Nobili, Blesso, & Sahebkar, ; Colalto, ; Hadi, Pourmasoumi, Najafgholizadeh, Kafeshani, & Sahebkar, ), there is a lack of conclusive information in efficacy and their possible side effects on diseases, which made it one of the most important problems faced by doctors (Hadi, Mohammadi, Hadi, Roshanravan, & Kafeshani, ; Izzo, Hoon‐Kim, Radhakrishnan, & Williamson, ). In this case, a comprehensive systematic review of available clinical trials can represent the most reliable evidence of medicinal plant efficacy.…”

Effect of sour tea supplementation on liver enzymes, lipid profile, blood pressure, and antioxidant status in patients with non‐alcoholic fatty liver disease: A double‐blind randomized controlled clinical trial

“…NAFLD can affect 15–30% of the general population, with higher prevalence in obese individuals (Bellentani, 2017). The pathogenesis of NAFLD is multifactorial and it seems that obesity, insulin resistance, hyperlipidemia, and oxidative stress have an important role in accumulation of fatty droplets in hepatocytes (Hadi, Pourmasoumi, Najafgholizadeh, Kafeshani, & Sahebkar, 2019; Mansour‐Ghanaei, Pourmasoumi, Hadi, & Joukar, 2019; Marjot, Moolla, Cobbold, Hodson, & Tomlinson, 2019). Poor control of NAFLD is associated with a range of problems (from benign steatosis to hepatic fibrosis and cirrhosis) that reduce quality of life, increase mortality, and impose high costs to the healthcare system (El‐Kader & El‐Den Ashmawy, 2015; Vuppalanchi & Chalasani, 2009).…”