Effect of pyometra on vascularity alterations, oxidative stress, histopathology and inflammatory molecules in feline

Abdelnaby, Elshymaa A.; Alhaider, Abdulrhman K.; Ghoneim, Ibrahim M.; Salem, Noha Y.; Ramadan, Eman S.; Farghali, Haithem A.; Khattab, Marwa S.; AbdElKader, Naglaa A.; Emam, Ibrahim A.

doi:10.1016/j.repbio.2024.100855

Cited by 4 publications

(1 citation statement)

References 48 publications

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“…There are few studies on Doppler-guided PP uterine involution in small ruminants, and most of them are based on postmortem examination [ 7 , 8 ]. B-mode ultrasonography was used in examination uterine changes [ 1 , 32 – 34 ], but the introduction of Doppler ultrasound is very critical in veterinary reproduction [ 35 ]. This study was intended to investigate, by pulsed-wave Doppler sonography, the involution of the goat uterus in the PP period following curcumin supplementation in the diet.…”

Section: Discussionmentioning

confidence: 99%

Determination of the impacts of supplemental dietary curcumin on post-partum uterine involution using pulsed-wave doppler ultrasonography in Zaraibi goat

Madbouly,

El-Shahat,

Abdelnaby

et al. 2024

BMC Vet Res

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This study aimed to evaluate the impacts of supplemental dietary curcumin on post-partum uterine involution using pulsed-wave Doppler ultrasonography in postpartum goats. Ten pluriparous Zaraibi goats were used and divided into two groups. Group 1 (n = 5; control) received only a base diet. Group 2 (n = 5; treated) received a base diet supplemented with curcumin (200 mg/kg diet) daily for 28 days, starting from day 1 postpartum (PP) till day 28 PP. Uterine morphometrical changes (uterine horn diameter; UHD and caruncle diameter; CD), uterine hemodynamics (resistance and pulsatility indices (RI and PI), systolic/ diastolic ratio (S/D), peak systolic velocity (PSV), end-diastolic velocity (EDV), blood flow volume (BFV), and blood flow rate (BFR)), and progesterone level were evaluated. Results revealed that the diameter of the uterine horn decreased rapidly from day 1 to day 10 PP (> 50%) but more steadily from day 14 to day 28 PP in both groups. After day 21 PP, there was nearly no reduction in UHD and CD in both groups. The treated group had lower values of the RI and PI (P < 0.05) than the control group. Regarding the BFR and BFV in the treated group, there was a significant increase (P < 0.05) on day 17 PP, then started to decrease till day 28 PP. While in the control group, there was a significant decrease (P < 0.05) in BFR and BFV from day 1 PP till day 28 PP. In conclusion, the incorporation of curcumin in the diet of PP Zaraibi goats improved reproductive performance via improvements in uterine morphometric changes as well as blood perfusion.

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Section: Discussionmentioning

confidence: 99%

Determination of the impacts of supplemental dietary curcumin on post-partum uterine involution using pulsed-wave doppler ultrasonography in Zaraibi goat

Madbouly,

El-Shahat,

Abdelnaby

et al. 2024

BMC Vet Res

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Outcomes of dietary alpha-lipoic acid on testicular vascularization, steroid hormones, and seminal quality in aged Baladi bucks

Abdelnaby,

Fathi,

Salem

et al. 2024

BMC Vet Res

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Background Senescence is accompanied by a progressive decrease in male reproductive performance, mainly due to oxidative stress and endothelial dysfunction. Alpha lipoic acid (ALA) is a potent antioxidant, that diffuses freely in aqueous and lipid phases, possessing anti-inflammatory and anti-apoptotic properties. This study aimed to examine the effects of supplemental dietary ALA on testicular hemodynamics (TH), circulating hormones, and semen quality in aged goats. Twelve Baladi bucks were divided into two groups (n = 6 each); the first fed a basic ration and served as a control group (CON), while the second received the basic ration supplemented with 600 mg ALA/ kg daily for consecutive eight weeks (ALA). Results There were improvements in testicular blood flow in the ALA group evidenced by a lower resistance index (RI) and pulsatility index (PI) concurrent with higher pampiniform-colored areas/pixel (W3-W6). There were increases in testicular volume and decreases in echogenicity (W3-W5; ALA vs. CON). Compared to the CON, ALA-bucks had higher serum concentrations of testosterone, estradiol, and nitric oxide (W3-W5). There were enhancements in semen traits (progressive motility, viability, morphology, and concentration, alanine aminotransferase enzyme) and oxidative biomarkers (catalase, total antioxidant capacity, and malondialdehyde). Conclusions ALA dietary supplementation (600 mg/kg diet) improved aged bucks’ reproductive performance by enhancing the testicular volume, testicular hemodynamics, sex steroids, and semen quality.

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Molecular Factors Involved in the Pathogenesis of Pyometra in Domestic Cats (Felis catus)

Nascimento,

Santos,

Silva

2024

Animals

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Pyometra is a major reproductive disorder affecting female cats. Characterized by the accumulation of purulent exudate in the uterus, it can lead to severe and potentially fatal complications. This pathology primarily occurs in adult cats during diestrus, but can also affect younger felines, often due to inappropriate administration of hormonal medications. While the etiopathogenesis of pyometra is better understood in bitches, few studies have addressed the molecular factors involved in feline pyometra. Therefore, this review aims to provide an up-to-date and comprehensive discussion of pyometra in cats, focusing on the regulation of molecular factors described in this species, including hormonal, redox, immunological, and growth factors. Understanding the regulation of these factors in pyometra is crucial for elucidating its pathogenesis in domestic cats and for improving diagnosis and identifying novel therapeutic approaches.

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Effect of pyometra on vascularity alterations, oxidative stress, histopathology and inflammatory molecules in feline

Cited by 4 publications

References 48 publications

Determination of the impacts of supplemental dietary curcumin on post-partum uterine involution using pulsed-wave doppler ultrasonography in Zaraibi goat

Determination of the impacts of supplemental dietary curcumin on post-partum uterine involution using pulsed-wave doppler ultrasonography in Zaraibi goat

Outcomes of dietary alpha-lipoic acid on testicular vascularization, steroid hormones, and seminal quality in aged Baladi bucks

Molecular Factors Involved in the Pathogenesis of Pyometra in Domestic Cats (Felis catus)

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