Effect of pyrroloquinoline quinone disodium in female rats during gestating and lactating on reproductive performance and the intestinal barrier functions in the progeny

Zhang, Boru; Yang, Wei; Zhang, Hongyun; He, Shiqi; Meng, Qiang; Chen, Zhihui; Shan, Anshan

doi:10.1017/s0007114519000047

Cited by 12 publications

(11 citation statements)

References 63 publications

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“…In this study, the mRNA expression of Occludin and ZO-1 were increased in the jejunal of weaned piglets with the PQQ•Na 2 supplementation. Zhang et al [17] reported that dietary PQQ•Na 2 supplementation during gestation and lactation of female rats can significantly increase the expression of ZO-1 and Claudin mRNA in the jejunal mucosa of weaned rats which is consistent with our study results.…”

Section: Discussionsupporting

confidence: 92%

“…The weaning process for pigs involves an abrupt dietary shift from sow milk to a completely feed-based diet that produces abrupt taxonomic and functional shifts in the intestinal microbiota [16]. PQQ•Na 2 has been reported to have an impact on the intestinal microbiota [17]. However, the impact of maternal dietary PQQ•Na 2 supplementation on the intestinal microbiota in offspring is still unknown.…”

Section: Introductionmentioning

confidence: 99%

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Effect of dietary pyrroloquinoline quinone disodium in sows on intestinal health of the offspring

Wang

Zhang

et al. 2020

Food Funct.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Effect of dietary pyrroloquinoline quinone disodium in sows on intestinal health of the offspring

Wang

Zhang

et al. 2020

Food Funct.

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“…In this study, the mRNA expression of Occludin and ZO-1 were increased in the jejunal of weaned piglets with the PQQ•Na 2 supplementation. Zhang et al [17] reported that dietary PQQ•Na 2 supplementation during gestation and lactation of female rats can signi cantly increase the expression of ZO-1 and Claudin mRNA in the jejunal mucosa of weaned rats which is consistent with our study results.…”

Section: Discussionsupporting

confidence: 92%

Effect of dietary pyrroloquinoline quinone disodium in sows on intestinal health of the offspring

Wang

Zhang

et al. 2020

Preprint

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Background: Pyrroloquinoline quinone (PQQ) is a putative essential nutrient and redox modulator in microorganisms, cell and animal models. The objective of this study was to investigate the effects of pyrroloquinoline quinone disodium (PQQ·Na2) in sows during gestation and lactation on intestinal health in the offspring.Results: The activities of SOD and GSH-Px were significantly (P<0.05) increased by PQQ·Na2 supplementation, and MDA activity was decreased (P<0.05) in the plasma of piglets. CAT, SOD and GSH-Px activities were significantly (P<0.05) increased, and MDA activity was decreased (P<0.05) in the small intestine of piglets. The mRNA expression levels of SOD1, CAT and MGST1 in the jejunum were increased in newborn piglets (P<0.05), and the mRNA expression levels of HO1, SOD1, CAT, SOD2, GPX4, GPX1 and GCLC in the jejunum were increased in weaned piglets (P<0.05). The mRNA expression of ZO-1 was increased (P<0.05) in the jejunum of newborn piglets, and the mRNA expression of Occludin and ZO-1 was increased (P<0.05) in the jejunum of weaned piglets. The villous height of the duodenum and jejunum of weaned piglets was increased (P<0.05) by dietary PQQ·Na2. In weaned piglets, Bacteroidetes and Firmicutes were the most prevalent phyla in both the Con and PQQ·Na2 treatment groups, and the most prevalent genera were Alloprevotella and Bacteroides. At the phylum level, the abundance of Firmicutes was significantly increased (P<0.05), and the abundance of Proteobacteria was significantly decreased (P<0.05). At the genus level, the abundance of Alloprevotella was significantly increased (P<0.05), and the abundance of Actinobacillus and Escherichia was decreased (P<0.05).Conclusions: In conclusion, dietary supplementation with PQQ·Na2 in sows during gestation and lactation had positive effects on intestinal health in offspring.

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“…Dietary supplementation with PQQ has been shown to improve neonatal growth and decrease redox potential in animals ( Killgore et al, 1989 ; Wang et al, 2015 ). The weaned pups of female rats that were administered PQQ-supplemented diets during gestation and lactation could increase intestinal tight junctions proteins expression ( Zhang et al, 2019 ). Furthermore, PQQ has been shown to regulate levels of jejunal inflammatory factors in weaned piglets ( Zhang et al, 2020 ) and promote T-cell immunological memory during immune responses ( Rucker et al, 2009 ).…”

Section: Introductionmentioning

confidence: 99%

Pyrroloquinoline Quinone Alleviates Jejunal Mucosal Barrier Function Damage and Regulates Colonic Microbiota in Piglets Challenged With Enterotoxigenic Escherichia coli

et al. 2020

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This study aimed to evaluate the effect of dietary supplementation with pyrroloquinoline quinone (PQQ) on gut inflammation and microbiota dysbiosis induced by enterotoxigenic Escherichia coli (ETEC). Twenty Duroc × Landrace × Yorkshire crossbred barrows were assigned to four groups: two E. coli K88 challenge groups and two non-challenge groups, each provided a basal diet supplemented with 0 or 3 mg/kg PQQ. On day 14, piglets were challenged with 10 mL 1 × 10 9 CFU/mL of E. coli K88 or PBS for 48 h. The villus height (VH) and villus height/crypt depth (VCR) ratio of the E. coli K88-challenged group supplemented with PQQ was significantly reduced than in the non-supplemented challenge group (P < 0.05), while levels of jejunal zonula occludens-3 (ZO-3), diamine oxidase, secretory immunoglobulin A (SIgA), interleukin-10 (IL-10), and IL-22 proteins were higher (P < 0.05), as were the activities of glutathione peroxidase, total superoxide dismutase, and total antioxidant capability (P < 0.05). Moreover, PQQ supplementation alleviated an increase in levels of mucosal inflammatory cytokines and reduced the activity of nuclear factor-kappa B (NF-κB) pathway by E. coli K88 (P < 0.05). Gene sequencing of 16S rRNA showed dietary supplementation with PQQ in E. coli K88-challenged piglets attenuated a decrease in Lactobacillus count and butyrate, isobutyrate level, and an increase in Ruminococcus and Intestinibacter counts, all of which were observed in non-supplemented, challenge-group piglets. These results suggest that dietary supplementation with PQQ can effectively alleviate jejunal mucosal inflammatory injury by inhibiting NF-κB pathways and regulating the imbalance of colonic microbiota in piglets challenged with E. coli K88.

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Effect of pyrroloquinoline quinone disodium in female rats during gestating and lactating on reproductive performance and the intestinal barrier functions in the progeny

Cited by 12 publications

References 63 publications

Effect of dietary pyrroloquinoline quinone disodium in sows on intestinal health of the offspring

Effect of dietary pyrroloquinoline quinone disodium in sows on intestinal health of the offspring

Effect of dietary pyrroloquinoline quinone disodium in sows on intestinal health of the offspring

Pyrroloquinoline Quinone Alleviates Jejunal Mucosal Barrier Function Damage and Regulates Colonic Microbiota in Piglets Challenged With Enterotoxigenic Escherichia coli

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