Effect of Qishen granules on isoproterenol‐induced chronic heart failure in rats evaluated by comprehensive metabolomics

Liu, Shuxin; Xing, Junpeng; Zheng, Zhong; Liu, Zhiqiang; Song, Fengrui; Liu, Shu

doi:10.1002/ptr.7576

Cited by 5 publications

(2 citation statements)

References 48 publications

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“…High-throughput mass spectrometry-based metabolomics has been used to investigate the underlying mechanisms of Qishen granules on myocardial ischemic chronic heart failure and revealed that Qishen granules might alleviate amino acid metabolism disorders by regulating endogenous metabolites [145]. UPLC/MS metabolomics analysis revealed that the Hu'po Anshen decoction regulated the abnormalities of glucose-alanine and malate-aspartate shuttle to promote bone formation [146].…”

Section: Multi-target and Effect Mechanism Exploration Of Herbal Medi...mentioning

confidence: 99%

Metabolomics for Clinical Biomarker Discovery and Therapeutic Target Identification

Lin,

Tian,

Guo

et al. 2024

Molecules

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As links between genotype and phenotype, small-molecule metabolites are attractive biomarkers for disease diagnosis, prognosis, classification, drug screening and treatment, insight into understanding disease pathology and identifying potential targets. Metabolomics technology is crucial for discovering targets of small-molecule metabolites involved in disease phenotype. Mass spectrometry-based metabolomics has implemented in applications in various fields including target discovery, explanation of disease mechanisms and compound screening. It is used to analyze the physiological or pathological states of the organism by investigating the changes in endogenous small-molecule metabolites and associated metabolism from complex metabolic pathways in biological samples. The present review provides a critical update of high-throughput functional metabolomics techniques and diverse applications, and recommends the use of mass spectrometry-based metabolomics for discovering small-molecule metabolite signatures that provide valuable insights into metabolic targets. We also recommend using mass spectrometry-based metabolomics as a powerful tool for identifying and understanding metabolic patterns, metabolic targets and for efficacy evaluation of herbal medicine.

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Section: Multi-target and Effect Mechanism Exploration Of Herbal Medi...mentioning

confidence: 99%

Metabolomics for Clinical Biomarker Discovery and Therapeutic Target Identification

Lin,

Tian,

Guo

et al. 2024

Molecules

View full text Add to dashboard Cite

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“…Qishen Granule can regulate the production of UDCA, glycodeoxycholic acid, and other BAs in the rat model of HF. [ 74 ] Figure 5 displays the role of Chinese medicine in treating HF by regulating BAs.…”

Section: Traditional Chinese Medicine (Tcm) Treats Hf By Regulating G...mentioning

confidence: 99%

The role of the gut microbiota and bile acids in heart failure: A review

Shi,

Wei,

Yuan

et al. 2023

Medicine

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Heart failure (HF) is the terminal manifestation of various cardiovascular diseases. Recently, accumulating evidence has demonstrated that gut microbiota are involved in the development of various cardiovascular diseases. Gut microbiota and their metabolites might play a pivotal role in the development of HF. However, previous studies have rarely described the complex role of gut microbiota and their metabolites in HF. In this review, we mainly discussed bile acids (BAs), the metabolites of gut microbiota. We explained the mechanisms by which BAs are involved in the pathogenesis of HF. We also discussed the use of gut microbiota and BAs for treating HF in Chinese medicine, highlighting the advantages of Chinese medicine in treating HF.

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Study on the protective mechanism of Xuemaitong Capsule against acute myocardial ischemia rat based on network pharmacology and metabolomics

Zou,

Zhang,

Zhang

et al. 2025

Journal of Chromatography B

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Effect of Qishen granules on isoproterenol‐induced chronic heart failure in rats evaluated by comprehensive metabolomics

Cited by 5 publications

References 48 publications

Metabolomics for Clinical Biomarker Discovery and Therapeutic Target Identification

Metabolomics for Clinical Biomarker Discovery and Therapeutic Target Identification

The role of the gut microbiota and bile acids in heart failure: A review

Study on the protective mechanism of Xuemaitong Capsule against acute myocardial ischemia rat based on network pharmacology and metabolomics

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